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Tigecycline

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Identification
Molecular formula
C29H39ClN4O8S
CAS number
220620-09-7
IUPAC name
(2R)-N-[(2S)-2-chloro-1-[(3R,6R)-3,4,5-trihydroxy-6-methylsulfanyl-tetrahydropyran-2-yl]propyl]-1-methyl-4-propyl-pyrrolidin-1-ium-2-carboxamide;chloride
State
State

At room temperature, tigecycline chloride is typically found as a solid in the form of a powder. It is usually reconstituted into a liquid solution before administration in clinical settings.

Melting point (Celsius)
0.00
Melting point (Kelvin)
273.15
Boiling point (Celsius)
25.00
Boiling point (Kelvin)
298.15
General information
Molecular weight
585.65g/mol
Molar mass
585.6450g/mol
Density
1.5480g/cm3
Appearence

Tigecycline chloride is an orange to light orange powder and is typically supplied in the form of a lyophilized (freeze-dried) powder for reconstitution into a solution for injection. This compound is sensitive to light and should be protected from direct exposure to maintain its chemical integrity.

Comment on solubility

Solubility of (2R)-N-[(2S)-2-chloro-1-[(3R,6R)-3,4,5-trihydroxy-6-methylsulfanyl-tetrahydropyran-2-yl]propyl]-1-methyl-4-propyl-pyrrolidin-1-ium-2-carboxamide;chloride

The solubility of this compound can be influenced by several factors due to its complex structure. Here are some key points to consider:

  • Polarity: The presence of multiple hydroxyl groups in its structure typically increases solubility in polar solvents, such as water.
  • Ionic Nature: Being a quaternary ammonium chloride, it is likely soluble in water due to its ionic character, facilitating interaction with polar solvent molecules.
  • Hydrophobic Regions: The hydrophobic portions of the compound, represented by the propyl groups, may reduce solubility in water, creating balance in solvent interaction.
  • Solvent Dependence: Solubility should be experimentally determined in various solvents—organic and aqueous—to gain a comprehensive understanding.
  • Temperature Effects: Increasing temperature often enhances solubility for many compounds; however, specific conditions for this compound would need assessment.

In conclusion, the solubility of (2R)-N-[(2S)-2-chloro-1-[(3R,6R)-3,4,5-trihydroxy-6-methylsulfanyl-tetrahydropyran-2-yl]propyl]-1-methyl-4-propyl-pyrrolidin-1-ium-2-carboxamide;chloride is a multidimensional characteristic hinging on structural features as well as the media in which it is placed.

Understanding its solubility is crucial for applications in pharmaceutical formulations and other chemical processes.

Interesting facts

Interesting Facts about (2R)-N-[(2S)-2-chloro-1-[(3R,6R)-3,4,5-trihydroxy-6-methylsulfanyl-tetrahydropyran-2-yl]propyl]-1-methyl-4-propyl-pyrrolidin-1-ium-2-carboxamide;chloride

This complex compound, often referred to as a quaternary ammonium salt, represents an intriguing class of molecules with significant biological implications. Here are some fascinating aspects:

  • Structural Complexity: The molecule features multiple functional groups and chirality centers, making it a robust subject for stereochemistry studies. Its intricate structure can inspire discussions about the role of stereochemistry in drug design.
  • Biological Activity: Compounds similar to this one often demonstrate notable biological activities. Their unique combinations of groups might influence their interaction with biological systems, potentially leading to therapeutic applications in areas like neurological disorders or metabolic diseases.
  • Chiral Centers: The presence of various chiral centers can result in different enantiomers with distinct pharmacological profiles. This raises interesting questions about the importance of chirality in medicinal chemistry.
  • Sulfhydryl Group Insight: The inclusion of a methylsulfanyl group could indicate potential antioxidant properties, as sulfhydryl compounds are often involved in redox reactions. Scientists may explore this aspect for further implications in health and disease.
  • Potential Applications: Due to its molecular structure, this compound may pave the way for new formulations in drug design, providing insights into how structural variations affect efficacy and safety profiles.

As scientists continue to explore compounds like this,
they unlock new potential realms of understanding in biochemistry and pharmacology. The interplay of structure, function, and biological activity remains an enchanting narrative in the world of chemical compounds.