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Methamphetamine hydrochloride

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Identification
Molecular formula
C10H15N · HCl
CAS number
298-93-1
IUPAC name
(2R)-N-methyl-1-phenyl-N-prop-2-ynyl-propan-2-amine;hydrochloride
State
State

Methamphetamine hydrochloride is typically found as a solid at room temperature. The solid state allows it to be formed into tablets or powdered for various uses.

Melting point (Celsius)
170.00
Melting point (Kelvin)
443.15
Boiling point (Celsius)
213.00
Boiling point (Kelvin)
486.15
General information
Molecular weight
185.71g/mol
Molar mass
185.7050g/mol
Density
1.0000g/cm3
Appearence

Methamphetamine hydrochloride appears as a crystalline solid, usually found in the form of crystals or powder. It can be colorless or white, although some impurities may lead to coloration. The substance is known for being hygroscopic, meaning it can absorb moisture from the air.

Comment on solubility

Solubility of (2R)-N-methyl-1-phenyl-N-prop-2-ynyl-propan-2-amine; hydrochloride

The solubility profile of (2R)-N-methyl-1-phenyl-N-prop-2-ynyl-propan-2-amine; hydrochloride can be quite intriguing due to its structural characteristics.

Factors influencing solubility include:

  • Polarity: Being a salt form, it typically exhibits higher solubility in polar solvents such as water.
  • Functional Groups: The presence of amine and phenyl groups can contribute to different solubility behaviors, as they affect hydrogen bonding and interactions with solvent molecules.
  • pH Sensitivity: The hydrochloride salt indicates that its solubility may be influenced by the pH of the solution, often increasing in acidic conditions.

Generally, many hydrochloride salts are known for their good solubility in aqueous solutions, making them suitable for pharmaceutical applications. Specifically, researchers often note:

  • Effective dissolution in physiological conditions, which aids in drug formulation.
  • Potential for enhanced bioavailability due to improved solubility, enabling better absorption in biological systems.

Overall, while the precise solubility can vary depending on various parameters, the hydrochloride form of this compound is expected to display significant solubility in water, allowing it to be effectively utilized in various chemical and medicinal applications.

Interesting facts

Interesting Facts about (2R)-N-methyl-1-phenyl-N-prop-2-ynyl-propan-2-amine; hydrochloride

(2R)-N-methyl-1-phenyl-N-prop-2-ynyl-propan-2-amine; hydrochloride is a compound that has garnered attention in the realms of medicinal chemistry and neuroscience. Its unique structure comprises a propargyl group, which contributes to its interesting biological properties.

Here are some fascinating aspects of this compound:

  • Drug Development: This compound is explored for its potential as a therapeutic agent. Its structural characteristics may influence neurotransmitter systems, paving the way for it to be a candidate in treating various neurological disorders.
  • Mechanism of Action: Compounds that contain amine groups are often involved in neurotransmission. The presence of a methyl group may enhance lipophilicity, enabling better penetration through biological membranes.
  • Synthesis Variability: The synthesis of (2R)-N-methyl-1-phenyl-N-prop-2-ynyl-propan-2-amine; hydrochloride invites innovative techniques in organic chemistry. Chemists use a variety of methods to create this compound, allowing for modification in its structural components for better efficacy.
  • Research Significance: The ongoing studies of this compound contribute to our understanding of psychostimulants and their interactions with biological systems, making it a valuable focus for researchers in pharmacology.

As we advance our knowledge in medicinal chemistry, compounds like (2R)-N-methyl-1-phenyl-N-prop-2-ynyl-propan-2-amine; hydrochloride represent the intersection of chemistry and medicine, emphasizing the importance of understanding complex molecular structures.

Synonyms
Selegiline hydrochloride
14611-52-0
Selegiline Hcl
l-Deprenyl hydrochloride
(-)-Deprenyl hydrochloride
Jumex hydrochloride
Eldepryl hydrochloride
Ensam
(-)-Deprenil hydrochloride
(-)-E-250 hydrochloride
Plurimen
HSDB 7183
FPF1100
Anipryl
CCRIS 8571
DTXSID9044584
UNII-6W731X367Q
6W731X367Q
NSC-759259
CHEBI:9087
DTXCID7024584
(-)-N,alpha-Dimethyl-N-2-propynylbenzeneethanamine hydrochloride
(-)-(R)-N,alpha-Dimethyl-N-2-propynylphenethylamine hydrochloride
(-)-(R)-N,alpha-Dimethyl-N-2-propynylphenethylamine monohydrochloride
Selegiline hydrochloride [USAN:USP]
NSC 759259
Benzeneethanamine, N,alpha-dimethyl-N-2-propynyl-, hydrochloride, (R)-
Selegiline hydrochloride (USAN:USP)
SELEGILINE HYDROCHLORIDE (MART.)
SELEGILINE HYDROCHLORIDE [MART.]
SELEGILINE HYDROCHLORIDE (USP-RS)
SELEGILINE HYDROCHLORIDE [USP-RS]
SELEGILINE HYDROCHLORIDE (EP MONOGRAPH)
SELEGILINE HYDROCHLORIDE (USP MONOGRAPH)
SELEGILINE HYDROCHLORIDE [EP MONOGRAPH]
SELEGILINE HYDROCHLORIDE [USP MONOGRAPH]
Amindan
Atapryl
Eldeprine
Movergan
Selepark
Seletop
N-methyl-N-((1R)-1-methyl-2-phenylethyl)prop-2-yn-1-aminium chloride
(R)-N,alpha-Dimethyl-N-2-propynyl-phenethylamine monohydrochloride
Benzeneethanamine, N,alpha-dimethyl-N-2-propynyl-, Hydrochloride,(R)-
Eldepryl
Zelapar
R-(-)-Deprenyl hydrochloride
(R)-N-Methyl-N-(1-phenylpropan-2-yl)prop-2-yn-1-amine hydrochloride
Jumex
Benzeneethanamine, N,alpha-dimethyl-N-2-propyn-1-yl-, hydrochloride (1:1), (alphaR)-
R(-)-Deprenyl hydrochloride
R-(-)-Deprenyl (hydrochloride)
(-)-Phenylisopropylmethylpropynylamine
Otrasel
(R)-(-)-Deprenyl hydrochloride
Zydis selegiline
(2R)-N-methyl-1-phenyl-N-prop-2-ynylpropan-2-amine;hydrochloride
MFCD00069299
Benzeneethanamine, N,?-dimethyl-N-2-propyn-1-yl-, hydrochloride (1:1), (?R)-
SMR000449328
Selegiline hydrochloride [USAN]
SR-01000597928
(-)-selegiline hydrochloride
Seledat
Vivapryl
Xilopar
Eldepryl (TN)
(R)-(-)-N,a-Dimethyl-N-(2-propynyl)phenethylamine hydrochloride; R(-)-N-a-Dimethyl-N-2-propynyl-benzeneethanamine hydrochloride
Prestwick_846
(R)-Deprenyl HCl
NCGC00016708-01
Selegiline (hydrochloride)
CAS-14611-52-0
R-(-)deprenyl hydrochloride
SCHEMBL41392
MLS000758294
MLS001423947
MLS002153281
MLS002222269
CHEMBL1200904
GLXC-05671
HMS1569P05
FPF-1100
Selegiline hydrochloride (JAN/USP)
Tox21_110572
Tox21_301846
SELEGILINE HYDROCHLORIDE [MI]
SELEGILINE HYDROCHLORIDE [JAN]
AKOS005166822
Benzeneethanamine, N,.alpha.-dimethyl-N-2-propynyl-, hydrochloride, (R)-
Tox21_110572_1
CCG-100773
KS-5098
NC00023
NC00605
SELEGILINE HYDROCHLORIDE [HSDB]
SELEGILINE HYDROCHLORIDE [VANDF]
NCGC00024994-06
NCGC00255797-01
SELEGILINE HYDROCHLORIDE [WHO-DD]
AC-18759
BS300066
HY-14199
Selegiline hydrochloride - Bio-X trade mark
SELEGILINE HYDROCHLORIDE [GREEN BOOK]
SELEGILINE HYDROCHLORIDE [ORANGE BOOK]
A11463
D00785
EN300-123011
SR-01000597928-1
SR-01000597928-5
SR-01000597928-6
Q27108267
R-(-)-Deprenyl hydrochloride, powder, >=98% (HPLC)
Z2768168341
Selegiline Hydrochloride 1.0 mg/ml in Methanol (as free base)
(R)-(-)-N,ALPHA-DIMETHYL-N-(2-PROPYNYL)PHENETHYLAMINE HCL
(R)-N-Methyl-1-phenyl-N-prop-2-ynylpropan-2-amine hydrochloride
(-)-(R)-N,.ALPHA.-DIMETHYL-N-2-PROPYNYLPHENETHYLAMINE HYDROCHLORIDE
methyl[(2R)-1-phenylpropan-2-yl](prop-2-yn-1-yl)amine hydrochloride
Selegiline hydrochloride, European Pharmacopoeia (EP) Reference Standard
Benzeneethanamine, N,|A-dimethyl-N-2-propyn-1-yl-, hydrochloride (1:1), (|AR)-
Selegiline hydrochloride, United States Pharmacopeia (USP) Reference Standard