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NADP+

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Identification
Molecular formula
C21H29N7O17P3
CAS number
53-59-8
IUPAC name
[[(2R,3R,4R,5R)-5-(6-aminopurin-9-yl)-3-hydroxy-4-phosphonooxy-tetrahydrofuran-2-yl]methoxy-hydroxy-phosphoryl] [(2R,3S,4R,5R)-5-(3-carbamoylpyridin-1-ium-1-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl]methyl hydrogen phosphate
State
State

NADP+ is generally in a solid state at room temperature, usually available as a powder for laboratory and research purposes.

Melting point (Celsius)
253.00
Melting point (Kelvin)
526.00
Boiling point (Celsius)
0.00
Boiling point (Kelvin)
0.00
General information
Molecular weight
745.42g/mol
Molar mass
0.0000g/mol
Density
2.1000g/cm3
Appearence

NADP+ typically appears as a white to off-white crystalline powder. It is often used in research and biochemical applications.

Comment on solubility

Solubility of the Compound

The compound with the formula C21H29N7O17P3 exhibits distinct solubility characteristics influenced by its complex structure. Understanding its solubility is crucial for applications in pharmaceutical and biochemical fields.

Factors Influencing Solubility

  • Polarity: The presence of multiple hydrophilic groups such as hydroxy (-OH) and phosphoryl (-PO3) enhances solubility in polar solvents like water.
  • Ionization: The amino group can improve solubility, especially in acidic or basic conditions where ionization occurs.
  • Hydrogen Bonding: Extensions from the molecular structure allow for intramolecular and intermolecular hydrogen bonding, further stabilizing solvation in aqueous environments.

As a result, this compound is expected to have a relatively high solubility in water, given its ability to interact favorably with polar solvents. However, solubility can change based on:

  • Temperature variations
  • Presence of other ions in solution
  • pH of the environment

To summarize, the functional groups present in this compound significantly contribute to its solubility. As widely accepted in chemistry, "the more polar a molecule, the more soluble it typically is in polar solvents." This principle underscores the potential applications of this compound in various aqueous-based formulations.

Interesting facts

Interesting Facts about the Compound

This fascinating compound, with a complex structure, highlights the intricate world of organic chemistry and its applications in biological systems. Below are some key aspects of this compound:

  • Bioactivity: This compound is derived from nucleoside analogs and has potential applications in medicinal chemistry, particularly in antiviral and anticancer therapies. The structure allows it to interact with various biological molecules, influencing cellular processes.
  • Sterochemistry: The specification of the stereochemistry (2R,3R,4R,5R and 2R,3S,4R,5R) in its formula indicates that this compound could exhibit chirality, which plays a crucial role in its biological activity. Different enantiomers may have different biological effects, making stereochemical studies vital.
  • Phosphate Functionalities: The presence of multiple phosphate groups suggests high energy content and the potential for the compound to act as a phosphate donor in biochemical reactions. This is particularly important in energy metabolism and signal transduction pathways.
  • Structure-Function Relationship: Understanding how the various functional groups interact and affect the compound’s activity can lead to insights into designing more effective drugs. As Richard Feynman once said, "What I cannot create, I do not understand." This compound certainly embodies the beauty of creation in chemistry.

As scientists continue to study such complex compounds, they often uncover novel pathways for treating diseases and enhancing our understanding of biological mechanisms. This highlights the importance of research in organic chemistry and its potential to contribute to advancements in healthcare.

Synonyms
NADP+
coenzyme II
NADP
Codehydrase II
nicotinamide adenine dinucleotide phosphate
NADP(+)
beta-NADP+
nadp nicotinamide-adenine-dinucleotide phosphate
[[(2R,3R,4R,5R)-5-(6-aminopurin-9-yl)-3-hydroxy-4-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl] [(2R,3S,4R,5R)-5-(3-carbamoylpyridin-1-ium-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl hydrogen phosphate
FENOPON TC-42
12751-04-1
141442-04-8
beta-nicotinamide adenine dinucleotide phosphate
53-59-8
nicotinamide adenine dinucleotide phosphate (NADP)
112429-07-9
122985-21-1
144906-21-8
604-79-5
NADP-ox
TPN-ox
b-NADP
BRN 3885115
[(2R,3R,4R,5R)-5-(6-aminopurin-9-yl)-3-hydroxy-4-phosphonooxyoxolan-2-yl]methyl [[(2R,3S,4R,5R)-5-(3-carbamoylpyridin-1-ium-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] hydrogen phosphate
2'-O-phosphonoadenosine 5'-{3-[1-(3-carbamoylpyridinio)-1,4-anhydro-D-ribitol-5-yl] dihydrogen diphosphate}
nicotinamide adenine dinucleotide-P
Mating pheromone precursor Er 2
TPN
((2R,3R,4R,5R)-5-(6-aminopurin-9-yl)-3-hydroxy-4-phosphonooxyoxolan-2-yl)methyl (((2R,3S,4R,5R)-5-(3-carbamoylpyridin-1-ium-1-yl)-3,4-dihydroxyoxolan-2-yl)methoxy-hydroxyphosphoryl) hydrogen phosphate
2'-O-phosphonoadenosine 5'-(3-(1-(3-carbamoylpyridinio)-1,4-anhydro-D-ribitol-5-yl) dihydrogen diphosphate)
Spectrum_001530
Spectrum2_000023
Spectrum4_000862
Spectrum5_001481
bmse000263
KBioGR_001523
KBioSS_002010
DivK1c_000706
SPBio_000085
Murine transcription factor E3
GTPL3045
CHEMBL5079525
BDBM11939
CHEBI:18009
KBio1_000706
KBio2_002010
KBio2_004578
KBio2_007146
NINDS_000706
DTXSID401102609
IDI1_000706
NS00070399
C00006
Q26987754
Adenosine 5a(2)-(trihydrogen diphosphate), 2a(2)-(dihydrogen phosphate), Pa(2)a5a(2)-ester with 3-(aminocarbonyl)-1-I(2)-D-ribofuranosylpyridinium