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D-Mannitol

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Identification
Molecular formula
C6H14O6
CAS number
69-65-8
IUPAC name
(2R,3R,4R,5R)-hexane-1,2,3,4,5,6-hexol
State
State

At room temperature, D-Mannitol is a solid. It is stable and retains its form under standard atmospheric conditions.

Melting point (Celsius)
165.00
Melting point (Kelvin)
438.15
Boiling point (Celsius)
0.00
Boiling point (Kelvin)
0.00
General information
Molecular weight
182.17g/mol
Molar mass
182.1720g/mol
Density
1.5200g/cm3
Appearence

D-Mannitol typically appears as a white, crystalline solid. It is known for its sweet taste and is often used as a sugar substitute in various food products.

Comment on solubility

Solubility of (2R,3R,4R,5R)-hexane-1,2,3,4,5,6-hexol

The compound (2R,3R,4R,5R)-hexane-1,2,3,4,5,6-hexol, with the chemical formula C6H14O6, exhibits interesting solubility properties due to its multiple hydroxyl (–OH) groups. These functional groups contribute to its ability to engage in hydrogen bonding with water molecules. As a result:

  • High Solubility in Water: The presence of several hydroxyl groups makes this compound highly soluble in polar solvents such as water.
  • Hydrophobic Regions: While the hydrocarbon part of the molecule (the hexane chain) tends to be hydrophobic, the predominance of hydrophilic –OH groups outweighs this effect.
  • Influence of Temperature: Generally, solubility can increase with temperature; however, for sugar alcohols similar to this hexol, the effect on solubility can vary.
  • Miscibility with Organic Solvents: Due to its structure, the compound may have limited solubility in non-polar organic solvents.

In summary, the solubility characteristics of (2R,3R,4R,5R)-hexane-1,2,3,4,5,6-hexol underscore the significant role of functional groups in determining the interactions with the surrounding medium. As a result, this compound can be utilized effectively in aqueous environments and formulations.

Interesting facts

Interesting Facts About (2R,3R,4R,5R)-hexane-1,2,3,4,5,6-hexol

(2R,3R,4R,5R)-hexane-1,2,3,4,5,6-hexol, commonly known as a hexitol, is a fascinating compound with distinct characteristics that showcase its importance in various fields of chemistry.

Chemical Structure

This compound features a unique polyol structure that includes six hydroxyl (–OH) groups attached to its hexane backbone. The chirality at each of the four carbon centers (specifically the 2nd, 3rd, 4th, and 5th positions) significantly influences the compound’s properties.

Biological Significance

Hexitols, including (2R,3R,4R,5R)-hexane-1,2,3,4,5,6-hexol, play essential roles in biological systems:

  • Energy Sources: They can function as carbohydrate derivatives, serving as energy sources for various organisms.
  • Osmoprotectants: These compounds help protect cells from osmotic stress, often found in environments with varying solute concentrations.
  • Pharmaceutical Applications: Some hexitols are used in pharmaceutical formulations for their humectant and stabilizing properties.

Applications

This compound has potential applications in multiple industries:

  • Food Industry: Used as a sugar substitute due to its sweetness and lower caloric content compared to traditional sugars.
  • Cosmetics: Incorporated in moisturizing products for its ability to retain moisture.
  • Industrial Chemistry: Acts as a building block for synthesizing other chemical compounds.

Research Interest

Researchers are continually investigating the properties and potential uses of (2R,3R,4R,5R)-hexane-1,2,3,4,5,6-hexol, as evidenced by studies exploring its chirality and the implications of its stereochemistry on reactivity and interaction in biochemical pathways. As it continues to be a subject of study, this compound may reveal more secrets and applications in the future.

In conclusion, (2R,3R,4R,5R)-hexane-1,2,3,4,5,6-hexol is not just a complex molecule; it's a pivotal compound with intriguing applications that stretches across biological and industrial landscapes.

Synonyms
D-mannitol
mannitol
69-65-8
Mannite
Osmitrol
Manna sugar
Cordycepic acid
Osmofundin
Resectisol
Diosmol
Mannit
Mannazucker
Mannidex
Mannigen
Mannistol
Invenex
Isotol
Osmosal
87-78-5
Marine Crystal
Maniton-S
D-(-)-Mannitol
Bronchitol
(2R,3R,4R,5R)-Hexane-1,2,3,4,5,6-hexaol
Mannitol, D-
(2R,3R,4R,5R)-hexane-1,2,3,4,5,6-hexol
Mannogem 2080
DL-Mannitol
Mannitol 5%
Mannitol (VAN)
Aridol
Mannitol 10%
Mannitol 15%
Mannitol 20%
Osmitrol 5% In Water
Osmitrol 10% In Water
Osmitrol 15% In Water
Osmitrol 20% In Water
SDM No. 35
Hexahydroxyhexane
Resectisol In Plastic Container
Mannitol (USP)
Mannitol 5% In Plastic Container
NCI-C50362
Mannitol 10% In Plastic Container
Mannitol 15% In Plastic Container
Mannitol 20% In Plastic Container
CCRIS 369
Mannitolum
HSDB 714
Manitol
CHEBI:16899
BRN 1721898
Maniton s
Mannitol;Mannite
UNII-3OWL53L36A
MFCD00064287
Mannitol [USP]
NSC 407017
3OWL53L36A
INS NO.421
OSMITROL 5% IN WATER IN PLASTIC CONTAINER
DTXSID1023235
OSMITROL 10% IN WATER IN PLASTIC CONTAINER
OSMITROL 15% IN WATER IN PLASTIC CONTAINER
OSMITROL 20% IN WATER IN PLASTIC CONTAINER
INS-421
E-421
NSC-407017
E421
DTXCID603235
133-43-7
mannitol-d
DTXSID30858955
4-01-00-02841 (Beilstein Handbook Reference)
Mannitol [USAN]
1,2,3,4,5,6-Hexanehexol
manita
NCGC00164246-01
MANNITOL (II)
MANNITOL [II]
Mannidex 16700
E 421
MANNITOL (MART.)
MANNITOL [MART.]
MANNITOL (USP-RS)
MANNITOL [USP-RS]
MTL
MANNITOL 25%
MANNITOL (EP IMPURITY)
MANNITOL [EP IMPURITY]
rel-(2R,3R,4R,5R)-Hexane-1,2,3,4,5,6-hexaol
MANNITOL (EP MONOGRAPH)
MANNITOL [EP MONOGRAPH]
MANNITOL (USP MONOGRAPH)
MANNITOL [USP MONOGRAPH]
D-Mannit
CAS-69-65-8
ISOMALT IMPURITY B (EP IMPURITY)
ISOMALT IMPURITY B [EP IMPURITY]
Osmitrol (TN)
SMR000857324
SR-01000838849
D-Mannitol, EP, USP grade
NSC 9256
EINECS 200-711-8
EINECS 201-770-2
Cordycepate
D-mitobronitol
MANNITOL 10% W/ DEXTROSE 5% IN DISTILLED WATER
AI3-19511
Mannit p
NSC407017
D-?Mannitol
Bronchitol (TN)
(D)-mannitol
Mannitol 25
Mannitol 35
Mannitol 60
D(-)Mannitol
Mannitol,(S)
Pearlitol 25 c
Pearlitol 50 c
Mannitol m300
Pearlitol 160 c
D-Mannitol - EP
Mannitol 200
Mannitol 300
Pearlitol 200 sd
Pearlitol 300 dc
Mannitol 2080
D-Mannit 1000 microg/mL in Methanol
ARIDOL KIT
D-Mannitol (Osmitrol)
D-Mannitol (JP18)
MANNITOL [HSDB]
MANNITOL [FCC]
MANNITOL 15% W/ DEXTROSE 5% IN SODIUM CHLORIDE 0.45%
MANNITOL 5% W/ DEXTROSE 5% IN SODIUM CHLORIDE 0.12%
Crystalline mannitol fine
MANNITOL [MI]
MANNITOL [VANDF]
D-Mannitol, ACS reagent
D-Mannitol, >=98%
M0044
D-MANNITOL [JAN]
SCHEMBL919
bmse000099
CHEMBL689
Epitope ID:114705
MANNITOL [WHO-DD]
Isomalt impurity, mannitol-
GD11 Rx SCM C5
Crystalline mannitol standard
D-MANNITOL [WHO-IP]
ED1D1E61-FEFB-430A-AFDC-D1F4A957FC3D
MLS001335977
MLS001335978
D-Mannitol, Biochemical grade
Crystalline mannitol extra-fine
MANNITOL [ORANGE BOOK]
D-Mannitol, AR, >=99%
D-Mannitol, LR, >=99%
CHEBI:29864
CURESTEM CELL HEALER C20
MANNITOLUM [WHO-IP LATIN]
DTXCID001324372
HMS2230N11
Aridol Bronchial Challenge Test Kit
HY-N0378
Tox21_112092
Tox21_201487
Tox21_300483
AKOS006280947
D-Mannitol, plant cell culture tested
Tox21_112092_1
BCP9000575
CCG-266445
D-Mannitol, BioXtra, >=98% (GC)
DB00742
MM02190
MM63310
D-Mannitol, NIST(R) SRM(R) 920
NCGC00164246-03
NCGC00164246-04
NCGC00164246-05
NCGC00164246-18
NCGC00254277-01
NCGC00259038-01
85085-15-0
AC-12776
AC-14054
AS-30501
D-Mannitol, tested according to Ph.Eur.
DA-65240
D-Mannitol, p.a., 96.0-101.5%
D-Mannitol, SAJ first grade, >=99.0%
SORBITOL-MANNITOL COMPONENT MANNITOL
D-Mannitol, SAJ special grade, >=99.0%
NS00068035
S2381
SW220287-1
C00392
D00062
EN300-212188
AB00443917_06
ISOMALT IMPURITY, MANNITOL- [USP IMPURITY]
ISOMALT IMPURITY, MANNITOL-(USP IMPURITY)
Q407646
SR-01000838849-3
SR-01000838849-4
BRD-K30374899-001-09-3
D-Mannitol, ACS reagent, for microbiology, >=99.0%
LACTITOL MONOHYDRATE IMPURITY C [EP IMPURITY]
D-Mannitol, meets EP, FCC, USP testing specifications
Mannitol, European Pharmacopoeia (EP) Reference Standard
Z1198149813
D-Mannitol, BioUltra, >=99.0% (sum of enantiomers, HPLC)
Mannitol, United States Pharmacopeia (USP) Reference Standard
D-Mannitol, >=99.9999% (metals basis), for boron determination
Mannitol, Pharmaceutical Secondary Standard; Certified Reference Material
201-770-2