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2'-Deoxy-6-thioguanosine

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Identification
Molecular formula
C10H13N5O3S
CAS number
589-61-9
IUPAC name
(2R,3S,4R,5R)-2-(hydroxymethyl)-5-(6-sulfanylpurin-9-yl)tetrahydrofuran-3,4-diol
State
State
At room temperature, 2'-Deoxy-6-thioguanosine is typically found in a solid state. It is a crystalline substance that can be handled easily in laboratory settings.
Melting point (Celsius)
213.00
Melting point (Kelvin)
486.15
Boiling point (Celsius)
211.00
Boiling point (Kelvin)
484.15
General information
Molecular weight
285.29g/mol
Molar mass
285.2850g/mol
Density
2.2000g/cm3
Appearence

2'-Deoxy-6-thioguanosine typically appears as a solid, crystalline powder. It may vary in color from white to slightly yellow, depending on the purity and specific form of the sample.

Comment on solubility

Solubility of (2R,3S,4R,5R)-2-(hydroxymethyl)-5-(6-sulfanylpurin-9-yl)tetrahydrofuran-3,4-diol

The solubility of the compound (2R,3S,4R,5R)-2-(hydroxymethyl)-5-(6-sulfanylpurin-9-yl)tetrahydrofuran-3,4-diol is influenced by several factors due to its complex structure. Here are some key points to consider:

  • Polar Functional Groups: The presence of hydroxymethyl groups significantly enhances its polarity, which promotes solubility in polar solvents such as water.
  • Sulfanyl Group: The attached sulfanyl group may contribute to the solubility as well, potentially enhancing interactions with solvents.
  • Hydrogen Bonding: The ability to form hydrogen bonds due to the hydroxyl groups adds to its solubility profile, facilitating dissolution in aqueous mediums.

In summary, it can be said that this compound is likely soluble in polar solvents, particularly water, due to the presence of hydroxymethyl and hydroxyl groups. However, to determine the precise solubility limits, empirical testing is recommended, as theoretical predictions might vary based on the solvent conditions.

Interesting facts

Interesting Facts about (2R,3S,4R,5R)-2-(hydroxymethyl)-5-(6-sulfanylpurin-9-yl)tetrahydrofuran-3,4-diol

This fascinating compound, often abbreviated for simplicity, possesses a unique stereochemistry with specific configurations at multiple chiral centers. Its design leads to intriguing properties that make it a compound of interest in various fields, particularly in pharmaceuticals and biochemistry.

Key Features

  • Structural Complexity: The presence of both a tetrahydrofuran ring and a purine derivative in its structure adds to its chemical diversity, making it a subject of study for its potential biological activities.
  • Potential Applications: This compound is often explored for its role in medicinal chemistry, particularly for compounds targeting specific biological pathways or acting as enzyme inhibitors.
  • Sulfanyl Group Influence: The sulfanylpurin group can have significant effects on the compound's reactivity and interaction with biological systems, broadening its potential utility in drug design.

Biological and Chemical Significance

Research indicates that similar structures can exhibit antiviral and anticancer properties, making them intriguing subjects in medical research. Compounds like this can also serve as important intermediates in the synthesis of more complex molecules, showing promise in the development of targeted therapies.

Quote from Researchers

As one prominent researcher noted, “The intricate nature of molecules like this one opens a plethora of possibilities for innovation in drug development and therapeutic advances.”

In summary, (2R,3S,4R,5R)-2-(hydroxymethyl)-5-(6-sulfanylpurin-9-yl)tetrahydrofuran-3,4-diol embodies a rich tapestry of chemical potential that continues to fascinate scientists and students alike.