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Nicotinamide adenine dinucleotide phosphate

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Identification
Molecular formula
C21H29N7O17P3
CAS number
53-59-8
IUPAC name
[(2R,3S,4R,5R)-4-hydroxy-2-(hydroxymethyl)-5-[6-(pyridine-3-carbonylamino)purin-9-yl]tetrahydrofuran-3-yl] dihydrogen phosphate
State
State

Nicotinamide adenine dinucleotide phosphate is typically found in a solid state at room temperature. However, in biological systems, it is commonly utilized in aqueous solutions.

Melting point (Celsius)
140.00
Melting point (Kelvin)
413.15
Boiling point (Celsius)
578.00
Boiling point (Kelvin)
851.15
General information
Molecular weight
744.42g/mol
Molar mass
744.4160g/mol
Density
1.7850g/cm3
Appearence
Nicotinamide adenine dinucleotide phosphate (NADP+) is typically found as a colorless, crystalline powder. It may also appear as a white solid in its pure form, although it is often handled in solution within biological contexts.
Comment on solubility

Solubility of [(2R,3S,4R,5R)-4-hydroxy-2-(hydroxymethyl)-5-[6-(pyridine-3-carbonylamino)purin-9-yl]tetrahydrofuran-3-yl] dihydrogen phosphate

The solubility of this complex compound is influenced by several key factors:

  • Polarity: The presence of hydroxyl groups and phosphate moieties generally enhances solubility in polar solvents, such as water.
  • Structural Complexity: The intricate structure may create steric hindrances that affect how easily the compound interacts with solvents.
  • pH Sensitivity: The solubility can vary significantly with changes in pH because of the ionizable phosphate groups.
  • Hydrogen Bonding: Molecules capable of forming hydrogen bonds will often exhibit increased solubility in aqueous solutions.

In practice, this compound is expected to demonstrate enhanced solubility due to its ability to form strong interactions with water molecules. However, variations can arise based on the specific solvent environment and the presence of ions. As a result, it is essential to conduct empirical solubility tests to determine precise behavior under various conditions.

In conclusion, while the theoretical framework suggests good solubility, empirical data will provide the ultimate insight into the compound’s solubility characteristics.

Interesting facts

Interesting Facts about the Compound

This compound is a fascinating example of a nucleoside analog, which plays a crucial role in biochemistry and pharmaceuticals. It can be recognized for its structural complexity, primarily due to the presence of multiple functional groups and a unique tetrahydrofuran ring.

Key Features:

  • Nucleoside Analog: This compound mimics natural nucleosides, making it useful in studying nucleic acid metabolism and cellular processes.
  • Pyridine Integration: The inclusion of a pyridine ring significantly influences the compound's interaction with various biological targets, enhancing its potential therapeutic applications.
  • Hydroxymethyl Group: The hydroxymethyl group contributes to the overall hydrophilicity, which is crucial for solubility in biological contexts.
  • Phosphate Group: The presence of dihydrogen phosphate indicates that the compound plays a role in energy transfer and signaling within cells.

This compound's synthesis often involves intricate multi-step reactions, showcasing the artistry of organic chemistry. As a result, it has become a valuable tool in drug development, particularly in antiviral and anticancer therapies.

In the words of a noted biochemist, "Understanding the minutiae of nucleoside analogs not only broadens our knowledge of molecular interactions but also opens new doors for therapeutic innovations."

This compound highlights the intersection of structural complexity and biological functionality, making it an exciting subject for ongoing research and study.

Synonyms
NIACINAMIDE ADENYLATE
Nicotinamide adenylate
UNII-A96HRS08UR
A96HRS08UR
(2R,3S,4R,5R)-4-Hydroxy-2-(hydroxymethyl)-5-(6-(nicotinamido)-9H-purin-9-yl)tetrahydrofuran-3-yl dihydrogen phosphate
958779-80-1
Q27273797