Skip to main content

Nicotinamide adenine dinucleotide phosphate

ADVERTISEMENT
Identification
Molecular formula
C21H29N7O17P3
CAS number
53-59-8
IUPAC name
[(2R,3S,4R,5R)-5-(3-carbamoylpyridin-1-ium-1-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl]methyl dihydrogen phosphate
State
State

At room temperature, the compound is in a solid state. It is usually encountered as a crystalline powder and is quite stable under normal conditions provided it is stored in a dry environment.

Melting point (Celsius)
300.00
Melting point (Kelvin)
573.15
Boiling point (Celsius)
0.00
Boiling point (Kelvin)
0.00
General information
Molecular weight
765.44g/mol
Molar mass
765.4410g/mol
Density
1.6940g/cm3
Appearence

The compound typically appears as a solid, crystalline powder. It is generally white to off-white in color. Under certain conditions, especially when exposed to moisture, it may form clumps or become slightly greyish.

Comment on solubility

Solubility Overview

The compound [(2R,3S,4R,5R)-5-(3-carbamoylpyridin-1-ium-1-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl]methyl dihydrogen phosphate is intriguing when it comes to its solubility characteristics. Understanding its solubility is crucial for various applications, especially in pharmaceuticals and biochemical research.

Factors Affecting Solubility

Several factors contribute to the solubility of this compound:

  • Polarity: The presence of polar functional groups like hydroxy (-OH) and phosphate (-PO₄) tends to enhance water solubility.
  • Charge: The cationic nature imparted by the carbamoylpyridine moiety may also support solubility in polar solvents.
  • Hydrogen Bonding: Intermolecular hydrogen bonding can significantly influence solubility, allowing the compound to interact favorably with solvent molecules.

General Insights

While specific solubility data for this compound may not be widely documented, it is reasonable to predict:

  • The compound likely exhibits good solubility in polar solvents, particularly water, due to its polar functional groups.
  • Solubility may decrease in non-polar solvents, reflecting a common trend for similar ionic and polar compounds.
  • Moreover, temperature and pH can significantly alter solubility properties, leading to different solubility profiles under varying experimental conditions.

In conclusion, while detailed empirical data may be scarce, the structural features and the presence of polar and charged entities strongly suggest that this compound is relatively soluble in water and other polar environments, making it a subject of interest in chemical solubility studies.

Interesting facts

Interesting Facts About [(2R,3S,4R,5R)-5-(3-carbamoylpyridin-1-ium-1-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl]methyl dihydrogen phosphate

This unique compound is a fascinating example of how complex organic chemistry can be, demonstrating the intersection of structures known as tetrahydrofuran and phosphates with a biological twist. Here are some compelling points regarding this compound:

  • Potential Pharmacological Uses: The presence of a pyridinium moiety suggests that this compound may interact with biological systems, opening avenues for its study as a potential pharmaceutical agent.
  • Stereochemistry: The compound's stereochemistry (2R,3S,4R,5R) is critical. Stereochemical configurations can significantly influence a compound's biological activity, efficacy, and safety profile, making this an intriguing area for research.
  • Biological Importance: Dihydroxy derivatives are often found in sugars and glycosides, indicating that the compound may play a significant role in biological pathways or mimic natural substrates in enzymatic reactions.
  • Functional Groups: The combination of hydroxyl groups and phosphates suggests potential reactivity and interaction with biomolecules, such as nucleotides or proteins, which is crucial in biochemical settings.
  • Research Applications: Compounds like this are often used as tools in chemical biology to probe mechanisms of enzymatic activity or as candidates for drug development, indicating its importance in scientific studies.

In conclusion, [(2R,3S,4R,5R)-5-(3-carbamoylpyridin-1-ium-1-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl]methyl dihydrogen phosphate is not just a chemical entity; it serves as a fascinating model for understanding complex interactions within biological systems. As researchers continue to explore its properties, we may uncover even more secrets hidden within its structure.

Synonyms
NMN(+)
beta-nicotinamide ribose monophosphate
3-carbamoyl-1-(5-O-phosphono-beta-D-ribofuranosyl)pyridinium
b-NMN
beta-delta-NMN
3-carbamoyl-1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-[(phosphonooxy)methyl]oxolan-2-yl]-1??-pyridin-1-ylium
b-D-NMN
SCHEMBL6858129
CHEBI:14648
DTXSID401175036
75414-16-3
s5259
Q27108984
3-(Aminocarbonyl)-1-(5-O-phosphono-I(2)-D-ribofuranosyl)pyridinium
3-Carbamoyl-1-b-D-ribofuranosylpyridinium hydroxide 5'-phosphate inner salt
3-(aminocarbonyl)-1-(5-O-phosphono-b-D-ribofuranosyl)-Pyridinium hydroxide inner salt
3-(aminocarbonyl)-1-(5-O-phosphono-b-D-ribofuranosyl)-Pyridinium inner salt
3-(aminocarbonyl)-1-(5-O-phosphono-beta-delta-ribofuranosyl)-Pyridinium inner salt
3-Carbamoyl-1-beta-delta-ribofuranosylpyridinium hydroxide 5'-phosphate inner salt
3-(aminocarbonyl)-1-(5-O-phosphono-beta-delta-ribofuranosyl)-Pyridinium hydroxide inner salt