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NADP+ (Nicotinamide Adenine Dinucleotide Phosphate)

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Identification
Molecular formula
C21H29N7O17P3
CAS number
53-59-8
IUPAC name
[[(2R,3S,4R,5R)-5-(4-amino-2-oxo-pyrimidin-1-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl]methoxy-hydroxy-phosphoryl] 2-(trimethylammonio)ethyl phosphate
State
State

At room temperature, NADP+ exists as a solid. It is a vital coenzyme involved in redox reactions, and it generally remains stable when stored under appropriate conditions, protected from moisture and light.

Melting point (Celsius)
135.00
Melting point (Kelvin)
408.15
Boiling point (Celsius)
620.00
Boiling point (Kelvin)
893.15
General information
Molecular weight
745.40g/mol
Molar mass
745.4040g/mol
Density
1.5960g/cm3
Appearence

NADP+ typically appears as a white or off-white powder at room temperature. It is odorless and can appear crystalline. The compound is often found in its sodium or potassium salts form when commercialized.

Comment on solubility

Solubility of (2R,3S,4R,5R)-5-(4-amino-2-oxo-pyrimidin-1-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl]methoxy-hydroxy-phosphoryl] 2-(trimethylammonio)ethyl phosphate

The solubility of the compound (2R,3S,4R,5R)-5-(4-amino-2-oxo-pyrimidin-1-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl]methoxy-hydroxy-phosphoryl] 2-(trimethylammonio)ethyl phosphate is of considerable interest due to its complex structure and functional groups. Understanding its solubility can provide insights into its potential applications and behavior in various environments.

Key factors influencing the solubility of this compound include:

  • Polarity: The presence of multiple hydroxyl groups and a trimethylammonio group enhances its polarity, which typically increases solubility in polar solvents such as water.
  • Ionization: The trimethylammonio group is likely to facilitate ionization in aqueous solutions, potentially enhancing solubility.
  • Hydrogen Bonding: The ability of hydroxyl groups to form hydrogen bonds contributes to solubility in hydrophilic environments.

It is important to note that while high solubility in polar solvents is anticipated, solubility in organic solvents may be limited due to the compound's overall structure. Additionally, temperature and pH can significantly affect solubility, potentially altering the compound's behavior under varying conditions.

In conclusion: The solubility of this compound is likely to be >influenced by its functional groups and structural characteristics, making it an intriguing compound deserving of further investigation in various solvents.

Interesting facts

Interesting Facts about the Compound

The compound known as (2R,3S,4R,5R)-5-(4-amino-2-oxo-pyrimidin-1-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl]methoxy-hydroxy-phosphoryl 2-(trimethylammonio)ethyl phosphate is a fascinating example of a complex molecular structure involved in biological activity. Here are some intriguing aspects of this compound:

  • Pharmaceutical Relevance: This compound belongs to a class of molecules that can interact with biological systems, making it potentially valuable in the fields of drug development and biochemical research.
  • Structural Diversity: The presence of a pyrimidine ring and a tetrahydrofuran moiety contributes to its diverse chemical properties, potentially enabling multiple mechanisms of action.
  • Enzyme Interaction: Given its phosphoryl group, this compound could play a role in enzyme activity modulation, affecting phosphorylation processes vital to cellular signaling pathways.
  • Biological Pathways: This compound may interact with key metabolic pathways, influencing processes such as nucleic acid metabolism and protein synthesis, which are essential for cellular function and regulation.
  • Potential Applications: Researchers are exploring similar analogs for their therapeutic potential, including applications in treating diseases associated with nucleic acid functions.

As scientific investigation continues, the nuanced understanding of this compound will enhance our grasp of its role within biological systems. It is a vivid reminder of the intricate relationship between chemistry and life.

Synonyms
citicoline
cytidine 5'-diphosphocholine
CDP-choline
987-78-0
citicholine
Citidoline
Cytidoline
Citicolina
Citicolinum
Cyscholin
Difosfocin
Emicholin
Somazina
Meibis
cytidine diphosphate choline
CDP-colina
Haocolin
Nicholin
Niticolin
Recofnan
Recognan
Suncholin
Colite
Ensign
Cereb
Cytidindiphosphocholin
Startonyl
Cytidine 5'-diphosphoric choline
Ubelin
CDP-colina [Spanish]
Cytidine 5'-(choline diphosphate)
Citicoline [INN:JAN]
Cytidine diphosphocholine
Cytidine 5'-(cholinyl pyrophosphate)
Choline 5'-cytidine diphosphate
Citicolinum [INN-Latin]
cidifos
Citicolina [INN-Spanish]
citidin difosfato de colina
Cytidinediphosphoric choline
Cytidine diphosphorylcholine
Choline cytidine diphosphate
Cytidine choline diphosphate
Cytidindiphosphocholin [German]
Cytidine diphosphate cholin ester
Cytidine 5-diphosphocholine
EINECS 213-580-7
Citidin difosfato de colina [Spanish]
Nicholin (TN)
NSC 122002
Cytidine 5'-diphosphate choline
BRN 4170138
Choline cytidine 5'-pyrophosphate ester
CDP choline
Cytidine diphosphate choline ester
Choline, ester with cytidine 5'-pyrophosphate
Cytidine, 5'-pyrophosphate, ester with choline
Cytidine 5'-(trihydrogen diphosphate), P'-(2-(trimethylammonio)ethyl) ester, inner salt
536BQ2JVC7
DTXSID9048431
CHEBI:16436
IP 302
IP-302
[2-CYTIDYLATE-O'-PHOSPHONYLOXYL]-ETHYL-TRIMETHYL-AMMONIUM
Citicolinum (INN-Latin)
Citicolina (INN-Spanish)
Choline, hydroxide, 5'-ester with cytidine 5'-(trihydrogen pyrophosphate), inner salt
{2-[({[(2R,3S,4R,5R)-5-(4-amino-2-oxo-1,2-dihydropyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}(hydroxy)phosphoryl phosphonato)oxy]ethyl}trimethylazanium
Cytidine 5'-(trihydrogen diphosphate), mono(2-(trimethylammonio)ethyl) ester, hydroxide, inner salt
CITICOLINE [MI]
CITICOLINE [INN]
CITICOLINE [JAN]
CITICOLINE [VANDF]
CITICOLINE (MART.)
CITICOLINE [MART.]
CITICOLINE (USP-RS)
CITICOLINE [USP-RS]
CITICOLINE [WHO-DD]
5'-O-[hydroxy({[2-(trimethylammonio)ethoxy]phosphinato}oxy)phosphoryl]cytidine
Choline, CDP
Cytidine 5' Diphosphocholine
Choline, Cytidine Diphosphate
Diphosphate Choline, Cytidine
5'-Diphosphocholine, Cytidine
(2-CYTIDYLATE-O'-PHOSPHONYLOXYL)-ETHYL-TRIMETHYL-AMMONIUM
P'-(2-(Trimethylammonio)ethyl) cytidine 5'-(monohydrogen diphosphate)
P'-[2-(Trimethylammonio)ethyl] cytidine 5'-(monohydrogen diphosphate)
5'-O-(hydroxy(((2-(trimethylammonio)ethoxy)phosphinato)oxy)phosphoryl)cytidine
Cytidine 5'-(trihydrogen diphosphate), P'-[2-(trimethylammonio)ethyl] ester, inner salt
(((2R,3S,4R,5R)-5-(4-amino-2-oxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl)methoxy-oxidophosphoryl) 2-(trimethylazaniumyl)ethyl phosphate;hydron
(2-(((((2R,3S,4R,5R)-5-(4-amino-2-oxo-1,2-dihydropyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl)methoxy)(hydroxy)phosphoryl phosphonato)oxy)ethyl)trimethylazanium
[[(2R,3S,4R,5R)-5-(4-amino-2-oxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-oxidophosphoryl] 2-(trimethylazaniumyl)ethyl phosphate;hydron
NSC-122002
DTXCID801764421
213-580-7
((2r,3s,4r,5r)-5-(4-amino-2-oxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl)methyl (hydroxy-(2-(trimethylazaniumyl)ethoxy)phosphoryl) phosphate
[(2r,3s,4r,5r)-5-(4-amino-2-oxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl [hydroxy-[2-(trimethylazaniumyl)ethoxy]phosphoryl] phosphate
cyticholine
[[(2R,3S,4R,5R)-5-(4-amino-2-oxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] 2-(trimethylazaniumyl)ethyl phosphate
2-(((((((2R,3S,4R,5R)-5-(4-Amino-2-oxopyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methoxy)(hydroxy)phosphoryl)oxy)oxidophosphoryl)oxy)-N,N,N-trimethylethanaminium
UNII-536BQ2JVC7
Citicoline Base
MFCD00868097
Citicoline;CDP-choline
Citicoline (JP18/INN)
CDP-choline (neutral charge)
SCHEMBL221081
RZZPDXZPRHQOCG-OJAKKHQRSA-N
GLXC-06711
AKOS025312525
CCG-269597
DB04290
DB12153
FC63074
DA-62349
C3438
C00307
D00057
D81851
EN300-7398882
Q28529682
Cytidine diphosphate-choline;CDP-Choline;Cytidine 5'-diphosphocholine
5'-O-[(S)-hydroxy({[2-(trimethylammonio)ethoxy]phosphinato}oxy)phosphoryl]cytidine