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Adenosine monohydrate

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Identification
Molecular formula
C10H15N5O4
CAS number
58-61-7
IUPAC name
(2R,3S,4S,5R)-2-(6-aminopurin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol;hydrate
State
State

At room temperature, Adenosine monohydrate is in a solid state, specifically as a crystalline powder. It is stable under normal conditions of use and storage.

Melting point (Celsius)
234.00
Melting point (Kelvin)
507.15
Boiling point (Celsius)
510.00
Boiling point (Kelvin)
783.15
General information
Molecular weight
267.24g/mol
Molar mass
285.2450g/mol
Density
1.2200g/cm3
Appearence

Adenosine monohydrate appears as a white crystalline powder. It has a slightly sweet taste and is soluble in water, forming a clear, colorless solution.

Comment on solubility

Solubility of (2R,3S,4S,5R)-2-(6-aminopurin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol; hydrate

The solubility of this complex compound is influenced by several factors that are critical to understanding its behavior in various solutions. Here are some notable points regarding its solubility:

  • Polarity: The presence of multiple hydroxyl groups in the structure tends to enhance its polarity, which generally increases solubility in polar solvents such as water.
  • Hydrates: As indicated by the term "hydrate" in the name, it forms hydrogen bonds with water molecules. This can increase the solubility in aqueous environments significantly.
  • pH Dependency: The solubility may also vary with pH levels due to the protonation of amino groups, which can alter interactions between the compound and the solvent.
  • Temperature Effects: Increased temperature often leads to enhanced solubility for many organic compounds, though specific behavior for this compound would need to be empirically determined.

In conclusion, the solubility of (2R,3S,4S,5R)-2-(6-aminopurin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol; hydrate is predicted to be favorable in aqueous solutions, driven by its polar functional groups and hydrogen bonding capabilities. However, understanding the complete solubility profile would require experimental validation under varying conditions.

Interesting facts

Interesting Facts about (2R,3S,4S,5R)-2-(6-aminopurin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol;hydrate

The compound you're exploring is a fascinating example of a nucleoside analog, which plays a pivotal role in molecular biology, particularly in the study of genetic material and therapeutics. Here are some intriguing insights:

Structural Significance

  • Stereochemistry: The specific stereochemical configuration at multiple chiral centers (2R, 3S, 4S, 5R) is crucial as it influences biological activity.
  • Hydroxymethyl Group: The presence of the hydroxymethyl group enhances the compound's potential interactions with biological macromolecules.

Biological Relevance

  • Nucleoside Analog: This compound mimics the structure of natural nucleosides, opening possibilities for use as antiviral agents or cancer therapies.
  • Role in Research: It is often utilized in research settings to investigate nucleotide metabolism and mechanism of action in various biological processes.

Applications and Potential

  • Drug Development: Due to its unique structure, it is a candidate for developing innovative therapeutic agents.
  • Gene Study: It may help in elucidating the functions of nucleotides and their interactions with DNA and RNA.

The investigation of this compound contributes to a broader understanding of how molecular structures dictate biological functions. As noted scientist Albert Einstein said, “The important thing is not to stop questioning. Curiosity has its own reason for existence.” This compound exemplifies how questioning in the realm of chemistry can lead to groundbreaking discoveries.

Synonyms
RefChem:549972
9H-Purin-6-amine, 9-beta-D-arabinofuranosyl-, hydrate (1:1)
Vidarabine monohydrate
24356-66-9
MFCD00150980
VIDARABINE G-2939UG/MG(AI)
Vidarabine (monohydrate)
(2R,3S,4S,5R)-2-(6-aminopurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol;hydrate
Vidarabine (USAN)
VIDARABINE [USAN]
(2R,3S,4S,5R)-2-(6-amino-9H-purin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol hydrate
(2R,3S,4S,5R)-2-(6-amino-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol hydrate
VIDARABINE [JAN]
Adenine arabinofuranoside hydrate
DRG-0058
UNII-FA2DM6879K
VidarabineH2O
Vidarabine H2O
Adenine, 9-beta-D-arabinofuranosyl-, monohydrate
Vidarabine [USAN:USP:INN:BAN:JAN]
9H-Purin-6-amine, 9-beta-D-arabinofuranosyl-, monohydrate
Vira-A (TN)
VIDARABINE [VANDF]
SCHEMBL2929
VIDARABINE [MART.]
SCHEMBL30994790
VIDARABINE [ORANGE BOOK]
DTXSID10947210
VIDARABINE [USP IMPURITY]
9H-Purin-6-amine, 9-.beta.-D-arabinofuranosyl-, monohydrate
VIDARABINE MONOHYDRATE [MI]
HY-N6666
s5297
AKOS025312428
CCG-267319
FV61478
NSC 757383
SY069450
A9251
CS-0083211
9-beta-D-Arabino furanosyl adenine monohydrate
Adenine 9-beta-D-Arabinofuranoside Monohydrate
C07195
D00406
T72143
VIDARABINE (200 MG)G-2939UG/MG(AI)
9-Pentofuranosyl-9H-purin-6-amine--water (1/1)
F986872
9-.BETA.-D-ARABINOFURANOSYLADENINE MONOHYDRATE
9H-Purin-6-amine,9-b-D-arabinofuranosyl-,hydrate(1:1)
(2R,3S,4S,5R)-2-(6-aminopurin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol;hydrate