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Thymidine monophosphate

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Identification
Molecular formula
C10H14N2O8P
CAS number
365-07-1
IUPAC name
[(2R,3S,4S,5R)-5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl]methyl dihydrogen phosphate
State
State

At room temperature, thymidine monophosphate is typically in a solid state.

Melting point (Celsius)
0.00
Melting point (Kelvin)
0.00
Boiling point (Celsius)
0.00
Boiling point (Kelvin)
0.00
General information
Molecular weight
402.18g/mol
Molar mass
402.1750g/mol
Density
2.3354g/cm3
Appearence

Thymidine monophosphate, also known as TMP, usually appears as a white crystalline powder.

Comment on solubility

Solubility of [(2R,3S,4S,5R)-5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl]methyl dihydrogen phosphate

The solubility of a compound can largely dictate its potential applications in pharmaceuticals, biochemistry, and materials science. In the case of [(2R,3S,4S,5R)-5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl]methyl dihydrogen phosphate, we observe certain characteristics that highlight its behavior in solution.

Factors Influencing Solubility:

  • Polarity: The presence of the phosphate group tends to enhance the compound's polarity, potentially increasing its solubility in polar solvents such as water.
  • Hydrogen Bonding: The hydroxyl groups can facilitate intermolecular hydrogen bonding, further enhancing solubility.
  • Molecular Structure: The chiral centers and the overall architecture of the compound may influence how it interacts with solvents, affecting solubility.

Lexicon of solubility often mentions the phrase "like dissolves like", which suggests that polar compounds will dissolve better in polar solvents compared to nonpolar solvents. Given the characteristics of this compound, it is likely soluble in aqueous environments, making it suitable for various biochemical applications.

Although solubility is influenced by various factors, predicting the exact solubility of this compound typically requires empirical testing. It's crucial to consider temperature, pH, and the presence of other solutes in solution for a comprehensive understanding of its solubility profile.

Interesting facts

Interesting Facts about [(2R,3S,4S,5R)-5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl]methyl dihydrogen phosphate

This compound is a fascinating example of a bioactive molecule that plays a significant role in biological systems. Here are some intriguing points about this compound:

  • Structural Complexity: The compound showcases a unique arrangement with multiple stereocenters, which contributes to its biological activity and specificity. The presence of a tetrahydrofuran ring adds to its structural intricacy.

  • Biological Relevance: Its similarity to nucleotides and pyrimidine derivatives makes it a candidate for research in the field of biochemistry, particularly in studies involving metabolic pathways and nucleic acid interactions.

  • Potential Applications: This compound could serve as a lead structure in drug design. Compounds with similar frameworks may exhibit antiviral or anticancer properties, making them important in pharmaceutical research.

  • Functional Groups: The presence of hydroxyl groups in tetrahydrofuran enhances the compound's reactivity and solubility, potentially influencing its interactions in biochemical systems.

  • Synthesis Challenges: The synthesis of such complex molecules often presents challenges, including control of stereochemistry and functional group compatibility, making it a suitable subject for advanced synthetic chemistry methodologies.

As a compound that merges structural complexity with potential therapeutic applications, [(2R,3S,4S,5R)-5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl]methyl dihydrogen phosphate exemplifies the interplay between molecular architecture and biological function. Researchers are continually exploring its properties to unravel further insights in medicinal chemistry.

Synonyms
18354-06-8
Uracil arabinotide
IYD0EF6ZRI
1-beta-D-Arabinofuranosyluracil 5'-Monophosphate
UNII-IYD0EF6ZRI
2,4(1H,3H)-Pyrimidinedione, 1-(5-O-phosphono-beta-D-arabinofuranosyl)-
1-.BETA.-D-ARABINOFURANOSYLURACIL 5'-MONOPHOSPHATE
Uracil, 1-beta-D-arabinofuranosyl-, 5'-(dihydrogen phosphate)
URACIL, 1-.BETA.-D-ARABINOFURANOSYL-, 5'-(DIHYDROGEN PHOSPHATE)
2,4(1H,3H)-PYRIMIDINEDIONE, 1-(5-O-PHOSPHONO-.BETA.-D-ARABINOFURANOSYL)-
URACIL ARABINOSE-5'-PHOSPHATE
[(2R,3S,4S,5R)-5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl dihydrogen phosphate
1-b-D-Arabinofuranosyluracil 5'-monophosphate
1-(5-O-Phosphono-?-D-arabinofuranosyl)-2,4(1H,3H)-pyrimidinedione; Uracil Arabinonucleoside 5'-Phosphate;
Uracil Arabinonucleoside 5'-Phosphate
SCHEMBL2056713
CHEBI:190946
1-(5-O-Phosphono-beta-D-arabinofuranosyl)-2,4(1H,3H)-pyrimidinedione
1-?-D-Arabinofuranosyluracil 5'-Monophosphate
1- beta -D-Arabinofuranosyluracil 5'-Monophosphate
Q27466836
1-(5-O-phosphono-beta-D-arabinofuranosyl)pyrimidine-2,4(1H,3H)-dione
((2R,3S,4S,5R)-5-(2,4-Dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl dihydrogen phosphate