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Cloxacillin

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Identification
Molecular formula
C19H18Cl2N3O5S
CAS number
61-72-3
IUPAC name
(2R,5S,6S)-6-[[3-(2,6-dichlorophenyl)-5-methyl-isoxazole-4-carbonyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
State
State

At room temperature, cloxacillin is in a solid state, often found as a powder. It is stable under normal conditions but should be kept in a tightly sealed container to maintain its efficacy and integrity.

Melting point (Celsius)
182.00
Melting point (Kelvin)
455.15
Boiling point (Celsius)
339.80
Boiling point (Kelvin)
612.95
General information
Molecular weight
435.87g/mol
Molar mass
435.8680g/mol
Density
1.4690g/cm3
Appearence

Cloxacillin is typically a white to off-white crystalline powder. It is usually packed in a sealed bottle or container to prevent contamination and degradation.

Comment on solubility

Solubility of (2R,5S,6S)-6-[[3-(2,6-dichlorophenyl)-5-methyl-isoxazole-4-carbonyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid

The solubility of this compound can be quite intricate due to its complex structure and the presence of various functional groups. Here are some key points to consider:

  • Polarity: The presence of functional groups such as the carboxylic acid and isoxazole moieties suggests that the compound may exhibit moderate to high polarity, which can influence its solubility in polar solvents.
  • Hydrogen bonding: The carboxyl group could engage in hydrogen bonding, potentially increasing solubility in water and other hydrogen-bond donating solvents.
  • Stability in solution: It’s essential to consider how the compound remains stable in solution, as some compounds may precipitate or decompose when dissolved.
  • Solvent effects: Depending on the solvent used, solubility may vary significantly. The solubility can be improved in solvents like dimethyl sulfoxide (DMSO) or ethanol, while in non-polar solvents, solubility may be minimal.

Overall, while the theoretical aspects suggest potential solubility in various solvents, empirical testing is crucial for defining its exact solubility characteristics. Such assessments not only confirm theoretical predictions but also uncover practical applications in pharmaceutical formulations.

Interesting facts

Interesting Facts about (2R,5S,6S)-6-[[3-(2,6-dichlorophenyl)-5-methyl-isoxazole-4-carbonyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid

This compound represents a remarkable advancement in the field of medicinal chemistry, particularly for its potential therapeutic applications. Its complex structure is characteristic of pharmaceutical compounds, showcasing both the intricacy and specificity required for effective drug design.

  • Structural Uniqueness: The bicyclic framework, combined with the isoxazole moiety, allows for a wide range of interactions within biological systems, making it a valuable candidate in drug discovery.
  • Targeted Action: This compound has been studied for its ability to selectively inhibit certain biological pathways, hinting at its potential use as an effective *antimicrobial agent* or in the treatment of diseases driven by specific biological markers.
  • Chirality Impact: The presence of multiple chiral centers (notably the R and S configurations) indicates that the compound's stereochemistry plays a crucial role in its bioactivity and pharmacokinetics, with different stereoisomers potentially exhibiting varied therapeutic effects.
  • Novel Functional Groups: The incorporation of thia and carbonyl groups enhances the compound’s reactivity and electronic properties, making it susceptible to further modifications that can improve its efficacy and safety profile.

As a testament to its potential, research continues into understanding how variations in the structure can lead to improved pharmacodynamics. As scientists push the boundaries of synthetic organic chemistry, compounds like this one illustrate the perfect blend of *creativity and scientific rigor* required to develop the next generation of therapeutics.

Ultimately, this compound exemplifies the ongoing innovations in drug design, where every aspect of its structure can be tuned for enhanced performance in clinical settings. In the world of chemistry, the intersection of *structure and function* is not just a principle; it is a source of inspiration for future discoveries.

Synonyms
CHEMBL1622721