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Vincristine

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Identification
Molecular formula
C46H56N4O10Cl
CAS number
2068-78-2
IUPAC name
[(2R,8R,10R,17S)-8-acetoxy-11-ethyl-5,7,14-trihydroxy-6,16,18-trimethoxy-13-(methoxymethyl)-11-azoniahexacyclo[7.7.2.12,5.01,10.03,8.013,17]nonadecan-4-yl] benzoate;chloride
State
State

At room temperature, vincristine is typically in a solid state, specifically a crystalline powder. When formulated as a sulfate salt for medicinal use, it is often dissolved into a liquid solution for intravenous administration.

Melting point (Celsius)
220.00
Melting point (Kelvin)
493.15
Boiling point (Celsius)
0.00
Boiling point (Kelvin)
0.00
General information
Molecular weight
923.04g/mol
Molar mass
923.0410g/mol
Density
1.4000g/cm3
Appearence

Vincristine is a white to off-white crystalline powder that is hygroscopic. It is often available as a sulfate salt, which is soluble in water, making it suitable for intravenous administration in medical use. Vincristine itself is typically administered as a sulfate in clinical settings due to its better solubility profile.

Comment on solubility

Solubility of the Compound

The compound [(2R,8R,10R,17S)-8-acetoxy-11-ethyl-5,7,14-trihydroxy-6,16,18-trimethoxy-13-(methoxymethyl)-11-azoniahexacyclo[7.7.2.12,5.01,10.03,8.013,17]nonadecan-4-yl] benzoate; chloride exhibits a nuanced solubility profile that can be attributed to several structural features.

Solubility Characteristics

Key points to refer to include:

  • Polarity: The varying functional groups such as hydroxyl (–OH) and methoxy (–OCH3) contribute to the overall polarity of the molecule. Compounds with multiple hydroxyl groups tend to **increase hydrophilicity**, which enhances solubility in polar solvents like water.
  • Ionic Nature: The presence of the azonia (quaternary ammonium) group introduces an ionic character to the molecule, suggesting good solubility in polar solvents and potential solubility in water.
  • Hydrophobic Regions: However, the hexacyclic structure may introduce significant hydrophobic regions that can limit solubility in aqueous environments.

As a result, this compound may exhibit:

  • High solubility in polar organic solvents (like ethanol or methanol)
  • Lower solubility in purely aqueous environments

In summary, while the complex structure and presence of functional groups may suggest a degree of solubility in polar solvents, the overall solubility will ultimately be dictated by the balance between hydrophilic and hydrophobic characteristics. Understanding these intricate properties can aid in predicting the behavior of the compound in various chemical contexts.

Interesting facts

Interesting Facts about the Compound

This complex organic compound, known as a hexacyclo nonadecan derivative, presents a fascinating study for chemists and biologists alike. Its intricate structure and various functional groups contribute to a myriad of potential applications in medicinal chemistry. Here are some intriguing aspects:

  • Natural Product Inspiration: Compounds like this often draw inspiration from natural products, exhibiting pharmacological activity that could be harnessed for drug development.
  • Structural Diversity: The presence of multiple –OH (hydroxyl) groups and methoxy functionalities showcases the compound's structural diversity, which can influence its reactivity and biological properties.
  • Stereochemistry Matters: The specified stereochemistry in the name indicates chirality, making this compound a potential candidate for studying stereochemical effects in biological systems.
  • Potential Applications: Such a compound could serve as a lead structure for developing new therapies due to its complex mechanism of action, possibly targeting multiple pathways in disease states.
  • Chloride Role: The inclusion of a chloride ion indicates a potential for ionic interactions, which might enhance solubility or aid in binding to biological targets.

From a research perspective, this compound exemplifies the *ephemeral beauty of organic synthesis*, where chemists meticulously craft precise molecular architectures. Furthermore, the exploration of compounds with such complexity opens doors to innovating drug design and understanding fundamental biological processes.

The study of this compound also encourages interdisciplinary dialogues among chemists, biologists, and pharmacologists, demonstrating how intricate designs in chemistry can lead to significant impacts in health and medicine. As you delve into the world of such compounds, remember the profound words: "The actions of a molecule reveal tales of interaction, potential, and transformation."