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Amphetamine

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Identification
Molecular formula
C9H13N
CAS number
300-62-9
IUPAC name
(2S)-1-phenylpropan-2-amine
State
State

At room temperature, amphetamine is usually encountered as a liquid but can also be found as a solid crystalline powder.

Melting point (Celsius)
11.30
Melting point (Kelvin)
284.45
Boiling point (Celsius)
203.00
Boiling point (Kelvin)
476.15
General information
Molecular weight
135.21g/mol
Molar mass
135.2060g/mol
Density
0.9200g/cm3
Appearence

Amphetamine is typically found in the form of a colorless liquid, although it can also appear as a crystalline solid. The solid form is usually a white crystalline powder.

Comment on solubility

Solubility of (2S)-1-phenylpropan-2-amine (C9H13N)

(2S)-1-phenylpropan-2-amine, also known as methamphetamine, exhibits specific solubility characteristics that are important to understand for both practical applications and scientific studies. Its solubility can be influenced by various factors such as temperature, pH, and the nature of the solvent used.

Solubility in Water

As an amine, (2S)-1-phenylpropan-2-amine is generally soluble in water due to its ability to form hydrogen bonds. However, the extent of this solubility can vary:

  • At room temperature, it shows moderate solubility.
  • Increases in temperature may enhance its solubility, allowing for greater dissolution.

Solubility in Organic Solvents

This compound is also soluble in many organic solvents, including:

  • Alcohols (e.g., ethanol, methanol)
  • Aromatic hydrocarbons (e.g., benzene, toluene)
  • Apolar solvents, which aids in various synthesis reactions.

In summary, the solubility of (2S)-1-phenylpropan-2-amine in different solvents makes it versatile for many chemical processes. Understanding its solubility properties is crucial for its application in both laboratory research and industry.

Interesting facts

Interesting Facts about (2S)-1-phenylpropan-2-amine

(2S)-1-phenylpropan-2-amine, commonly known as amphetamine, is a remarkable compound with significant therapeutic and historical importance. This compound belongs to the class of phenethylamines and plays a crucial role in pharmacology.

Key Points of Interest

  • Pharmacological Applications: Amphetamine is primarily used in the treatment of Attention Deficit Hyperactivity Disorder (ADHD) and narcolepsy, enhancing focus and reducing excessive sleepiness.
  • Cognitive Enhancement: It is known for its stimulant properties, which can increase alertness, attention, and energy levels, making it a subject of interest in cognitive enhancement research.
  • Historical Context: Amphetamines were first synthesized in the late 19th century and became popular during World War II among soldiers for their stimulant effects.
  • Mechanism of Action: The compound works by increasing the release of neurotransmitters such as dopamine and norepinephrine in the brain, which are essential for mood regulation and cognitive function.

One interesting aspect of (2S)-1-phenylpropan-2-amine is its potential for misuse. Due to its stimulating effects, it has been associated with substance abuse, making its regulation and responsible use a significant focus in medical and ethical discussions. As noted by experts, "The challenge lies in balancing the therapeutic benefits against the risk of addiction."

In conclusion, (2S)-1-phenylpropan-2-amine is not just a chemical compound; it is a powerful tool in medicine, embodying both great potential and serious responsibility.

Synonyms
dextroamphetamine
D-Amphetamine
(S)-Amphetamine
(+)-Amphetamine
51-64-9
XELSTRYM
TZ47U051FI
Dexamphetamine
Dexamfetamine
(+)-(S)-Amphetamine
(2S)-1-phenylpropan-2-amine
Dexadrine
Dexidrine
(S)-(+)-Amphetamine
(S)-1-Phenyl-2-aminopropane
(S)-1-Phenyl-2-propylamine
(+)-alpha-Methylphenethylamine
Desamfetamina
Amsustain
Dephadren
Sympamin
(+)-alpha-Methylphenylethylamine
(+)-Phenaminum
D-(S)-Amphetamine
(S)-(+)-beta-Phenylisopropylamine
Dexanfetamina
(2S)-(+)-Amphetamine
dextro-Amphetamine
(S)-alpha-Phenylethylamine
D-alpha-methylphenethylamine
Dexamfetamina
Dexamfetaminum
Dexamphetaminum
D-AM
(S)-alpha-Methylphenethylamine
D-1-Phenyl-2-aminopropane
D-2-Amino-1-phenylpropane
(S)-alpha-methylbenzeneethanamine
Dexedrine
Dextroamphetamine [USAN]
D-1-Phenyl-2-aminopropan
D-(+)-Amphetamine
Dexamfetaminum [INN-Latin]
Dexamfetamina [INN-Spanish]
Dexamphetaminum [INN-Latin]
Dexanfetamina [INN-Spanish]
Amphetamine, d-
dextro Amphetamine
(alphaS)-alpha-methylbenzeneethanamine
alpha-Methylphenethylamine, d-form
Benzeneethanamine, alpha-methyl-, (S)-
Amfetamine, (s)-
CHEBI:4469
HSDB 3055
Phenethylamine, alpha-methyl-, d-
EINECS 200-112-1
UNII-TZ47U051FI
NSC 73713
Phenethylamine, alpha-methyl-, (+)-
BRN 2205872
Dexamfetamine (INN)
Dexamfetamine [INN]
Dextroamphetamine (USAN)
NSC-73713
CHEMBL612
Benzeneethanamine, alpha-methyl-, (alphaS)-
DTXSID8022907
4-12-00-02587 (Beilstein Handbook Reference)
Desamfetamina [DCIT]
Dexamfetaminum (INN-Latin)
Dexamfetamina (INN-Spanish)
Dexamphetaminum (INN-Latin)
Dexanfetamina (INN-Spanish)
DEA No. 1100
d-1-Phenyl-2-aminopropan [German]
d Amphetamine
(S)-1-Phenyl-2-propanamine
(+)-.alpha.-Methylphenethylamine
NSC73713
Amphetamine (d)
S(+)amphetamine
Xelstrym (TN)
1WE
Amphetamine [DEA]
Benzeneethanamine, .alpha.-methyl-, (S)-
NSC126789
Epitope ID:224549
SCHEMBL8859
1-methyl-2-phenyl-ethylamine
(S)-1-phenylpropan-2-amine
51-64-9 (free base)
DEXTROAMPHETAMINE [MI]
DEXAMFETAMINE [WHO-DD]
DTXCID802907
GTPL2147
DEXTROAMPHETAMINE [HSDB]
DEXTROAMPHETAMINE [VANDF]
BETA-PHENYL-ISO-PROPYL AMINE
BDBM50022723
PDSP1_001511
PDSP2_001495
AB03711
DB01576
NS00075524
Phenethylamine, alpha-methyl-, (+)- (8CI)
C07884
D03740
AB01563181_01
Benzeneethanamine, alpha-methyl-, (aS)- (9CI)
Q1706418
BRD-K21160401-065-01-0
(S)-(+)-Amphetamine (Dextroamphetamine) 1.0 mg/ml in Methanol
Dextroamphetamine; D-amphetamine; Dexamphetamine; Dexedrine; Dextrostat
200-112-1