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Folic acid

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Identification
Molecular formula
C19H19N7O6
CAS number
59-30-3
IUPAC name
(2S)-2-[[4-[(2-amino-4-oxo-1H-pteridin-6-yl)methylamino]benzoyl]amino]pentanedioic acid
State
State

Folic acid is a solid at room temperature. It is usually available as a crystalline powder or in granular form. Due to its solid nature, it is stable under normal conditions but must be protected from excessive heat and light to prevent degradation.

Melting point (Celsius)
250.00
Melting point (Kelvin)
523.00
Boiling point (Celsius)
0.00
Boiling point (Kelvin)
0.00
General information
Molecular weight
441.40g/mol
Molar mass
441.4040g/mol
Density
1.4000g/cm3
Appearence

Folic acid appears as a yellow or orange crystalline powder. It is nearly odorless and has a bitter taste. This compound is sensitive to air and light, which can lead to its decomposition over time.

Comment on solubility

Solubility of (2S)-2-[[4-[(2-amino-4-oxo-1H-pteridin-6-yl)methylamino]benzoyl]amino]pentanedioic acid

The solubility characteristics of the compound (2S)-2-[[4-[(2-amino-4-oxo-1H-pteridin-6-yl)methylamino]benzoyl]amino]pentanedioic acid, with the chemical formula C19H19N7O6, are intriguing and depend on a variety of factors.

Factors Influencing Solubility:

  • Polarity: The presence of amino groups and carboxylic acid moieties in the structure contributes to the compound's polarity, potentially enhancing its solubility in polar solvents like water.
  • Hydrogen Bonding: The ability to form hydrogen bonds, particularly due to the amino and carbonyl groups, can significantly influence solubility in aqueous environments.
  • pH Dependence: Being a diprotic acid, its solubility can vary with the pH of the solution, typically increasing when the solution is more basic, as the carboxylic acid groups may deprotonate.
  • Temperature: Solubility is generally affected by temperature; as temperature increases, solubility tends to increase due to enhanced molecular interactions.

It is also worth noting that the solubility of this specific compound may require empirical testing to fully understand its behavior in various solvents. The statement "Like dissolves like" often holds true; thus, polar solvents are likely to solvate this compound more efficiently than non-polar ones. Understanding the solubility profile is crucial for applications in pharmaceuticals and biochemical research, where bioavailability is essential.

Interesting facts

Interesting Facts About (2S)-2-[[4-[(2-amino-4-oxo-1H-pteridin-6-yl)methylamino]benzoyl]amino]pentanedioic acid

(2S)-2-[[4-[(2-amino-4-oxo-1H-pteridin-6-yl)methylamino]benzoyl]amino]pentanedioic acid, commonly known as a derivative of pteridine, is a compound that has garnered significant interest in the field of medicinal chemistry. Its complex structure allows for unique interactions within biological systems, making it a subject of numerous studies in drug development.

Key Highlights:

  • Role in Biology: This compound is linked to crucial biological pathways, particularly in the metabolism of folate and the synthesis of nucleotides.
  • Potential Therapeutic Uses: Due to its structural characteristics, it may be explored for its effectiveness against certain cancers and infections.
  • Structure Activity Relationship (SAR): Researchers leverage the detailed structure of this compound to understand how modifications can enhance its biological activity, focusing on the pteridin-6-yl moiety that contributes to its pharmacological properties.

As noted by chemists, "the intricacy of pteridine derivatives opens up new avenues for targeted therapy." This potential for tailor-made therapeutic options continues to spur innovation in the pharmaceutical landscape.

Moreover, understanding the synthesis and behavior of this compound contributes to broader research into bioactive molecules, leading to the discovery of new drugs with improved efficacy and reduced side effects. Continuous investigation into its pharmacodynamics and pharmacokinetics remains critical as researchers strive to unravel its full potential.