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L-Valine

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Identification
Molecular formula
C5H11NO2
CAS number
72-18-4
IUPAC name
(2S)-2-amino-3-methyl-butanoic acid
State
State

At room temperature, L-Valine is in a solid state, specifically in a crystalline form. It is stable under normal conditions of use and storage.

Melting point (Celsius)
298.00
Melting point (Kelvin)
571.15
Boiling point (Celsius)
265.10
Boiling point (Kelvin)
538.25
General information
Molecular weight
117.15g/mol
Molar mass
117.1470g/mol
Density
1.2300g/cm3
Appearence

L-Valine is a white crystalline powder. It typically appears as an odorless white solid.

Comment on solubility

Solubility of (2S)-2-amino-3-methyl-butanoic acid

(2S)-2-amino-3-methyl-butanoic acid, with the chemical formula C5H11NO2, is an amino acid and demonstrates unique solubility characteristics that are important in various biochemical applications.

Typically, amino acids like (2S)-2-amino-3-methyl-butanoic acid are known to be:

  • Soluble in water: This solubility is primarily due to the presence of the amino group (-NH2) and the carboxylic acid group (-COOH), which can engage in hydrogen bonding with water molecules.
  • Partially soluble in organic solvents: While predominantly hydrophilic, this compound can exhibit some solubility in polar organic solvents, though it is far less soluble compared to its solubility in water.

In solution, (2S)-2-amino-3-methyl-butanoic acid can exist in different ionic forms depending on the pH, further influencing its solubility. Typically, at physiological pH, the carboxyl group is deprotonated, resulting in an anionic form that may enhance its interaction with water.

In summary:

  • Water solubility: High
  • Solubility in acids/bases: Variable, based on pH
  • Organic solvent solubility: Low to moderate

Understanding the solubility of (2S)-2-amino-3-methyl-butanoic acid is crucial for applications in biochemistry and pharmaceuticals, where its behavior in different solvents can impact its functionality and interaction with biological systems.

Interesting facts

Interesting Facts About (2S)-2-Amino-3-methyl-butanoic Acid

(2S)-2-amino-3-methyl-butanoic acid, commonly known as Leucine, is one of the essential amino acids that play a vital role in human nutrition and metabolism. As an important building block for proteins, leucine is particularly noted for its impact on muscle development and recovery, making it a popular supplement among athletes and bodybuilders.

Key Functions of Leucine:

  • Protein Synthesis: Leucine activates the mTOR (mammalian target of rapamycin) pathway, which initiates protein synthesis, thereby aiding in muscle repair and growth.
  • Energy Source: During prolonged exercise or fasting, leucine can serve as a source of energy, helping to maintain performance.
  • Blood Sugar Regulation: This amino acid may assist in stabilizing blood sugar levels by influencing insulin release.

Sources of Leucine:

Leucine is primarily found in a variety of protein-rich foods, including:

  • Meat (beef, chicken, pork)
  • Fish (salmon, tuna)
  • Dairy products (milk, cheese, yogurt)
  • Legumes (soybeans, lentils)

As an essential amino acid, the body cannot synthesize leucine, requiring it to be obtained through diet. This characteristic underscores the importance of a balanced nutritional intake, especially for those engaged in high levels of physical activity.

Interesting Fact:

In the field of medicine, leucine has been studied for its potential therapeutic roles in conditions such as muscle wasting, obesity, and diabetes management. Research continues to explore its full potential and benefits.

In conclusion, leucine is not just a simple amino acid; its multifaceted roles in health, nutrition, and exercise science highlight its significance in both biochemistry and everyday life. As stated by many nutritionists, "A diet rich in essential amino acids like leucine is crucial for maintaining optimal health."

Synonyms
L-valine
valine
72-18-4
(S)-Valine
H-Val-OH
(2S)-2-amino-3-methylbutanoic acid
(S)-2-Amino-3-methylbutanoic acid
2-Amino-3-methylbutyric acid
valina
(S)-2-Amino-3-methylbutyric acid
L-alpha-Amino-beta-methylbutyric acid
Valinum [Latin]
Valina [Spanish]
Butanoic acid, 2-amino-3-methyl-
Valine (VAN)
Valinum
Valine [USAN:INN]
L-valin
VALINE, L-
L(+)-alpha-Aminoisovaleric acid
(S)-alpha-Amino-beta-methylbutyric acid
Butanoic acid, 2-amino-3-methyl-, (S)-
NSC 76038
2-Amino-3-methylbutyric acid, (S)-
2-Amino-3-methylbutanoic acid, (S)-
val
CHEBI:16414
UNII-HG18B9YRS7
EINECS 200-773-6
HG18B9YRS7
MFCD00064220
NSC-76038
(L)-valine
2-Amino-3-methylbutanoic acid (VAN)
Valine (L-Valine)
7004-03-7
HSDB 7800
L-2-Amino-3-methylbutanoic acid
l-(+)-alpha-Aminoisovaleric acid
L-2-Aminoisovaleric Acid
(S)-alpha-Aminoisovaleric acid
Valinum (Latin)
DTXSID40883233
EC 200-773-6
VALINE (II)
VALINE [II]
L-Val
VALINE (MART.)
VALINE [MART.]
valin
2-aminoisovaleric acid
Hval
VALINE (EP MONOGRAPH)
VALINE [EP MONOGRAPH]
VALINE (USP MONOGRAPH)
VALINE [USP MONOGRAPH]
(2S)-2-amino-3-methylbutanoate
alpha-aminoisovaleric acid
2-amino-3-methylbutanoate
Racemic valine
L-(+)-a-Aminoisovaleric acid
s-valin
L-(+)-.alpha.-Aminoisovaleric acid
L-a-Amino-b-methylbutyric acid
3h-l-valine
(S)-a-Amino-b-methylbutyric acid
L-Valine, FCC
Valine (USP)
(+)-valine
L-Valine,(S)
1t4s
L-Valine (JP18)
L-Valine, 99%
VALINE [VANDF]
VALINE [HSDB]
VALINE [USAN]
(S)-Val
L-Val-4
L-VAL-OH
VALINE [INN]
VALINE [WHO-DD]
VALINE [MI]
2-Amino-3-methylbutyrate
L-VALINE [FCC]
L-VALINE [JAN]
bmse000052
bmse000811
bmse000860
L-(+)-a-Aminoisovalerate
L-a-Amino-b-methylbutyrate
SCHEMBL8516
(S)-A-Aminoisovaleric acid
L-VALINE [USP-RS]
2-Aminoisovaleric acid,(S)
CHEMBL43068
(S)-a-Amino-b-methylbutyrate
L-(+)-alpha-Aminoisovalerate
L-iso-C3H7CH(NH2)COOH
GTPL4794
(S)-2-Amino-3-methylbutyrate
(S)-2-Amino-3-methylbutanoate
L-alpha-Amino-beta-methylbutyrate
(S)-2-amino-3-methyl-Butanoate
DTXCID201022782
Pharmakon1600-01301009
HY-N0717
(S)-alpha-Amino-beta-methylbutyrate
(S)-2-amino-3-methyl-butyric acid
BDBM50463208
NSC760111
s5628
(S)-2-amino-3-methyl-Butanoic acid
L-Valine, 98.5-101.5%
AKOS015841564
CCG-266067
CS-W020706
DB00161
FV00534
L-Valine, 99%, natural, FCC, FG
NSC-760111
RP10200
NCGC00344520-01
AS-12787
L-Valine, BioUltra, >=99.5% (NT)
L-Valine, SAJ special grade, >=98.5%
DB-029989
DB-234161
L-Valine, reagent grade, >=98% (HPLC)
H-Val-OH; L-2-Amino-3-methylbutanoic acid
V0014
EN300-52625
C00183
D00039
L-Valine, Cell Culture Reagent (H-L-Val-OH)
LYSINE ACETATE IMPURITY D [EP IMPURITY]
M02950
SBI-0633454.0002
(S)-(+)-2-AMINO-3-METHYLBUTYRIC ACID
Q483752
L-Valine, certified reference material, TraceCERT(R)
F8889-8698
Valine, European Pharmacopoeia (EP) Reference Standard
Z756430564
1B39571B-0AE8-4A9A-AE80-4B898D11A981
L-Valine, dimer, meets the analytical specifications of USP
L-Valine, United States Pharmacopeia (USP) Reference Standard
L-Valine, Pharmaceutical Secondary Standard; Certified Reference Material
InChI=1/C5H11NO2/c1-3(2)4(6)5(7)8/h3-4H,6H2,1-2H3,(H,7,8)/t4-/m0/s
200-773-6
L-Valine, from non-animal source, meets EP, JP, USP testing specifications, suitable for cell culture, 98.5-101.0%