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Ropivacaine

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Identification
Molecular formula
C17H26N2O
CAS number
84057-95-4
IUPAC name
(2S)-N-(2,6-dimethylphenyl)-1,2-dimethyl-piperidine-2-carboxamide
State
State

At room temperature, ropivacaine is usually in a solid state as a white powder. It is stable under standard conditions and is typically kept in this form until prepared for clinical use in solution.

Melting point (Celsius)
158.00
Melting point (Kelvin)
431.15
Boiling point (Celsius)
294.00
Boiling point (Kelvin)
567.15
General information
Molecular weight
274.41g/mol
Molar mass
274.4140g/mol
Density
1.0040g/cm3
Appearence

Ropivacaine typically appears as a white powder, which is odorless. It is often encountered in its hydrochloride salt form for pharmaceutical purposes, where it is similarly a white crystalline powder.

Comment on solubility

Solubility of (2S)-N-(2,6-dimethylphenyl)-1,2-dimethyl-piperidine-2-carboxamide

The solubility of (2S)-N-(2,6-dimethylphenyl)-1,2-dimethyl-piperidine-2-carboxamide can be influenced by various factors, necessitating a closer look at its properties:

  • Polarity: The compound contains both a hydrophobic aromatic ring and a hydrophilic carboxamide group, making its overall polarity moderate.
  • Solvent Compatibility: It is likely to be more soluble in organic solvents such as ethanol, methanol, or dimethyl sulfoxide (DMSO) due to its hydrophobic regions.
  • Temperature Effects: Increased temperature may enhance its solubility in organic solvents, as it often encourages molecular interaction and disrupts solute-solvent interactions.
  • pH Considerations: The solubility can vary with pH; polar interactions may increase in more acidic or basic environments, affecting solubility dynamics.

In conclusion, while the exact solubility values for (2S)-N-(2,6-dimethylphenyl)-1,2-dimethyl-piperidine-2-carboxamide in water might be limited, its potential solubility in organic solvents highlights the importance of solvent selection in any experimental setup involving this compound.

Interesting facts

Interesting Facts about (2S)-N-(2,6-dimethylphenyl)-1,2-dimethyl-piperidine-2-carboxamide

This intriguing chemical compound, known for its complex structure, has garnered attention for several reasons within the realms of medicinal chemistry and pharmacology.

  • Pharmacological Significance: The compound's structure hints at its potential role in drug design, particularly in developing analgesics and anti-inflammatory agents. Its piperidine moiety is often found in various therapeutic agents.
  • Synthetic Pathways: The synthesis of this compound may involve reactions such as amine formation, acylation, and aromatic substitution. Exploring these synthesis pathways provides valuable insights into the methods chemists use to construct complex molecules.
  • Chirality: The presence of a chiral center at the piperidine nitrogen adds a layer of complexity. Chirality can significantly affect a compound's biological activity, making stereochemistry a crucial consideration in pharmaceutical development.
  • Application Potential: Compounds similar to this one have been studied for their interactions with neurotransmitter systems, potentially impacting mood regulation and pain perception.
  • Practical Uses: Beyond its medicinal properties, derivatives of this compound may find applications in organic synthesis and materials chemistry, contributing to innovative solutions in various fields.

In conclusion, the study of (2S)-N-(2,6-dimethylphenyl)-1,2-dimethyl-piperidine-2-carboxamide not only enriches our understanding of synthetic techniques but also presents exciting possibilities in drug development. As noted by many researchers, \"the complexity of such compounds often leads to greater discoveries in science and medicine.\" Exploring its potential further could unlock novel therapies for various health conditions.