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Methamphetamine

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Identification
Molecular formula
C10H15N
CAS number
537-46-2
IUPAC name
(2S)-N-methyl-1-phenyl-propan-2-amine
State
State

At room temperature, methamphetamine is generally a solid as it is most commonly encountered as a powder or crystal.

Melting point (Celsius)
170.00
Melting point (Kelvin)
443.15
Boiling point (Celsius)
215.00
Boiling point (Kelvin)
488.15
General information
Molecular weight
149.23g/mol
Molar mass
149.2330g/mol
Density
0.9375g/cm3
Appearence

Methamphetamine typically appears as a crystalline white powder but can also be found in pill form or as chunky crystals resembling ice, which is also known as crystal meth. It has a bitter taste and is odorless.

Comment on solubility

Solubility of (2S)-N-methyl-1-phenyl-propan-2-amine

The solubility of (2S)-N-methyl-1-phenyl-propan-2-amine, commonly known as methamphetamine, varies significantly based on its chemical environment. Here are some key points regarding its solubility:

  • Solvent Compatibility: Methamphetamine is generally soluble in organic solvents such as ethanol, acetone, and dichloromethane.
  • Water Solubility: While methamphetamine is somewhat soluble in water, its polar nature limits the extent of solubility. It is known to have a solubility of approximately 1 g in 30 mL of water at room temperature.
  • Influence of pH: The solubility can also be affected by the pH of the solution. Increasing the acidity by lowering the pH can enhance the ionization of the compound, thus increasing its solubility in aqueous solutions.
  • Temperature Dependence: Like many compounds, solubility increases with the temperature of the solvent; therefore, heating can improve the dissolution rate.

In summary, the solubility of (2S)-N-methyl-1-phenyl-propan-2-amine is influenced by a variety of factors, including the choice of solvent, pH conditions, and temperature. Understanding these aspects is crucial for effectively handling and utilizing this compound in various applications.

Interesting facts

Interesting Facts About (2S)-N-methyl-1-phenyl-propan-2-amine

(2S)-N-methyl-1-phenyl-propan-2-amine, commonly known as Methamphetamine, is a fascinating compound with significant implications in both chemistry and society. Here are some noteworthy aspects of this compound:

  • Historical Context: Methamphetamine was first synthesized in 1893 by Japanese chemist Nagai Nagayoshi. It became popular during World War II as a means to enhance alertness and stamina in soldiers.
  • Mechanism of Action: The compound works primarily by increasing the levels of dopamine in the brain, creating feelings of euphoria, increased energy, and improved focus.
  • Legal Status: Methamphetamine is classified as a Schedule II controlled substance in many countries due to its high potential for abuse and addiction. Interestingly, it has legitimate medical uses, such as in treating ADHD and obesity.
  • Structural Features: The chemical structure of (2S)-N-methyl-1-phenyl-propan-2-amine contributes to its potency. The presence of a methyl group allows for greater lipid solubility, enhancing its ability to cross the blood-brain barrier.
  • Sympathomimetic Effects: Methamphetamine exhibits sympathomimetic properties, leading to heightened heart rate and blood pressure, which can pose serious health risks.
  • Societal Impact: The illicit use of this compound has led to significant social issues, including addiction, crime, and various health problems. Community efforts focus on education and treatment programs to combat the epidemic.

In summary, while (2S)-N-methyl-1-phenyl-propan-2-amine possesses valuable medicinal properties, its potential for misuse highlights the importance of responsible research and public policy in the realm of chemical compounds.

Synonyms
METHAMPHETAMINE
Metamfetamine
d-Deoxyephedrine
d-Desoxyephedrine
d-N-Methylamphetamine
N-Methylamphetamine
d-Phenylisopropylmethylamine
(S)-Methamphetamine
D-1-Phenyl-2-methylaminopropane
(S)-Methylamphetamine
Metamfetamina
Metamfetaminum
Metanfetamina
Methyl-beta-phenylisopropylamine
537-46-2
(S)-(+)-Deoxyephedrine
(2S)-N-methyl-1-phenylpropan-2-amine
S-(+)-Methamphetamine
(S)-N,alpha-Dimethylbenzeneethanamine
D-N,alpha-dimethylphenethylamine
Crank
Methamphetaminum
Crystal Meth
(+)-2-(N-Methylamino)-1-phenylpropane
Metamfetaminum [INN-Latin]
Metamfetamina [INN-Spanish]
Metanfetamina [INN-Spanish]
Methamphetaminum [INN-Latin]
(+)-N,alpha-Dimethylphenethylamine
dextromethamphetamine
D-1-Phenyl-2-methylaminopropan
(+)-N,alpha-Dimethyl-beta-phenylethylamine
Meth (Street Name)
(+)-(S)-N-alpha-Dimethylphenethylamine
Metamfetaminum [Latin]
(alphaS)-N,alpha-dimethylbenzeneethanamine
ICE [Street Name]
Crank [Street Name]
Speed [Street Name]
NSC 25115
CHEBI:6809
HSDB 3359
(s)-phenylmethylaminopropane
EINECS 208-668-7
Crystal Meth [Street Name]
NSC-25115
UNII-44RAL3456C
Phenethylamine, N,alpha-dimethyl-, (+)-
44RAL3456C
Benzeneethanamine, N,alpha-dimethyl-, (alphaS)-
J6.362B
DTXSID8037128
Crank (Street Name)
ICE (Street Name)
Speed (Street Name)
Metamfetaminum (Latin)
Metamfetaminum (INN-Latin)
Crystal Meth (Street Name)
Metamfetamina (INN-Spanish)
Metanfetamina (INN-Spanish)
Methamphetaminum (INN-Latin)
N Methylamphetamine
metamfetamine racemate
DTXCID6017128
N06BA03
208-668-7
d-Methamphetamine
Methylamphetamine
Metamphetamine
d-Methylamphetamine
Norodin
(+)-Methylamphetamine
d-(S)-Methamphetamine
(+)-N-Methylamphetamine
(+)-(S)-Deoxyephedrine
1-Phenyl-2-methylaminopropane
(+)-methamphetamine
Meth
Metamfetamine [INN]
N-Methyl-beta-phenylisopropylamine
1-Phenyl-2-methylamino-propan [German]
d-1-Phenyl-2-methylaminopropan [German]
2S-(+)-Methamphetamine
(S)-(+)-Methamphetamine
N-Methyl-beta-phenylisopropylamin [German]
(S)-N,alpha-Dimethylbenzeneethanoamine
(S)-(+)-N,alpha,dimethylphenethylamine
Metamfetamine (INN)
Benzeneethanamine, N,alpha-dimethyl-, (S)-
Methyl-.beta.-phenylisopropylamine
d-N,.alpha.-Dimethylphenethylamine
Stimulex
Speed
Desoxyephedrine hydrochloride
1-Phenyl-2-methylamino-propan
N-Methyl-beta-phenylisopropylamin
Methamphetaminum [JP]
Metanfetamina [Spanish]
N-Methyl-1-phenyl-2-propanamine
(+ )-Methylamphetamine
Benzeneethanamine, N,alpha-dimethyl-, (+)-
DEA No. 1105
B40
Methamphetamine (MA)
Benzeneethanamine, N,.alpha.-dimethyl-, (S)-
Phenethylamine, N,.alpha.-dimethyl-, (S)-(+)-
Epitope ID:178090
intra-venous methamphetamine
Phenethylamine, N,alpha-dimethyl-, (S)-(+)-
Benzeneethanamine,.alpha.-dimethyl-, (S)-
d-N,a-dimethylphenethylamine
METHAMPHETAMINE [MI]
SCHEMBL42615
Phenethylamine,.alpha.-dimethyl-, (S)-(+)-
METHAMPHETAMINE [HSDB]
METAMFETAMINE [WHO-DD]
METHAMPHETAMINE [VANDF]
CHEMBL1201201
WLN: 1MY1&1R -D
N,I+/--Dimethyl-phenethyl amine
Desyphed hydrochloride (Salt/Mix)
NSC25115
N-Methyl-1-phenyl-2-propanamine #
BDBM50359499
PDSP1_001404
PDSP1_001405
PDSP2_001388
PDSP2_001389
(+)-N,.alpha.-Dimethylphenethylamine
DB01577
Desoxyephedrine hydrochloride (Salt/Mix)
methyl[(2S)-1-phenylpropan-2-yl]amine
Phenethylamine,.alpha.-dimethyl-, (+)-
(+)-(S)-N-.alpha.-Dimethylphenethylamine
Benzeneethanamine,.alpha.-dimethyl-, (+)-
NS00000412
Phenethylamine, N,.alpha.-dimethyl-, (+)-
Benzeneethanamine, N,.alpha.-dimethyl-, (+)-
C07164
D08187
(+)-N,.alpha.-Dimethyl-.beta.-phenylethylamine
Q191924
Phenethylamine, N,alpha-dimethyl-, (S)-(+)- (8CI)
Benzeneethanamine, N,alpha-dimethyl-, (alphaS)- (9CI)
(+)-N,.alpha.-Dimethylphenethylamine hydrochloride (Salt/Mix)