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Bafilomycin A1

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Identification
Molecular formula
C35H58O9
CAS number
88899-55-2
IUPAC name
(2S,4R,8S,11S,12R)-6,6-diethyl-12-fluoro-11-hydroxy-8-(2-hydroxyacetyl)-9,13-dimethyl-5,7-dioxapentacyclo[10.8.0.02,9.04,8.013,18]icosa-14,17-dien-16-one
State
State

At room temperature, Bafilomycin A1 is in a solid state, usually in the form of crystalline powder.

Melting point (Celsius)
153.80
Melting point (Kelvin)
426.95
Boiling point (Celsius)
921.15
Boiling point (Kelvin)
1 194.30
General information
Molecular weight
622.84g/mol
Molar mass
622.8360g/mol
Density
1.2201g/cm3
Appearence

Bafilomycin A1 is typically a crystalline solid that may appear colorless or have a faint yellow tint, depending on its purity and the method of isolation.

Comment on solubility

Solubility of (2S,4R,8S,11S,12R)-6,6-diethyl-12-fluoro-11-hydroxy-8-(2-hydroxyacetyl)-9,13-dimethyl-5,7-dioxapentacyclo[10.8.0.02,9.04,8.013,18]icosa-14,17-dien-16-one

The solubility of (2S,4R,8S,11S,12R)-6,6-diethyl-12-fluoro-11-hydroxy-8-(2-hydroxyacetyl)-9,13-dimethyl-5,7-dioxapentacyclo[10.8.0.02,9.04,8.013,18]icosa-14,17-dien-16-one is a multifaceted aspect influenced by its complex structure. Here are several key points regarding its solubility:

  • Polarity: Given the presence of hydroxyl groups and fluoro substituents, solubility in polar solvents like water could be favorable.
  • Hydrophobic Character: The extensive hydrocarbon portions of the molecule may diminish solubility in polar solvents, rendering it more amenable to non-polar solvents.
  • Solvent Type Influence: This compound might exhibit solubility in organic solvents such as ethanol and acetone, while showing limited solubility in hydrocarbons.
  • Temperature Dependency: Solubility can increase with temperature; thus, analyzing the compound at elevated temperatures might provide insights into its solubility behavior.
  • Application Context: Its solubility is a crucial factor for applications in pharmaceuticals, where optimal solubility enhances bioavailability.

In summary, the solubility of this compound can be expected to vary widely depending on environmental conditions and the solvent used. Understanding its solubility is vital for predicting its behavior in different systems and applications.

Interesting facts

Interesting Facts about (2S,4R,8S,11S,12R)-6,6-Diethyl-12-fluoro-11-hydroxy-8-(2-hydroxyacetyl)-9,13-dimethyl-5,7-dioxapentacyclo[10.8.0.02,9.04,8.013,18]icosa-14,17-dien-16-one

This compound is a fascinating example of complex organic chemistry, belonging to a class of molecules known as steroidal compounds. Its intricate structure showcases a pentacyclic framework, which highlights the compound’s rigidity and unique properties. Here are some interesting aspects of this compound:

  • Stereochemistry: The compound exhibits chiral centers at multiple positions, leading to several possible stereoisomers. This stereochemistry is crucial for its biological activity and interaction with other molecules.
  • Functional Groups: The presence of the fluoro group and multiple hydroxy groups not only influences chemical reactivity but also contributes to the compound's solubility and potential pharmacological properties.
  • Biological Significance: Compounds with complex polycyclic frameworks are often found in natural products, particularly those with medicinal properties. Such compounds can serve as leads for drug discovery and development.
  • Synthesis Challenges: The synthesis of such a complex molecule requires advanced synthetic techniques, leading to significant developments in organic synthesis practices. The careful manipulation of multiple functional groups can create a rich learning environment for chemists.
  • Potential Applications: The unique structure may allow for various applications in pharmaceuticals, potentially targeting specific biological pathways due to its structural motifs.

In conclusion, the richness of this compound’s structure not only provides learning opportunities for students and chemists alike but also raises intriguing questions about its use in drug development and the mechanistic pathways of its biological activity. As famed chemist Linus Pauling once said, "The best way to have a good idea is to have a lot of ideas," and studying such compounds can lead to innovative breakthroughs in chemistry.