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Fluocinonide

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Identification
Molecular formula
C26H32FNO7
CAS number
356-12-7
IUPAC name
(2S,4R,8S,11S,12R)-8-acetyl-12-fluoro-11-hydroxy-6,6,9,13-tetramethyl-5,7-dioxapentacyclo[10.8.0.02,9.04,8.013,18]icosa-14,17-dien-16-one
State
State

At room temperature, fluocinonide is in a solid state, typically appearing as a powder.

Melting point (Celsius)
276.00
Melting point (Kelvin)
549.15
Boiling point (Celsius)
660.00
Boiling point (Kelvin)
933.15
General information
Molecular weight
494.54g/mol
Molar mass
494.5140g/mol
Density
1.4000g/cm3
Appearence

Fluocinonide is typically a white to off-white powder. It may be crystalline and is odorless.

Comment on solubility

Solubility Overview

The compound (2S,4R,8S,11S,12R)-8-acetyl-12-fluoro-11-hydroxy-6,6,9,13-tetramethyl-5,7-dioxapentacyclo[10.8.0.02,9.04,8.013,18]icosa-14,17-dien-16-one presents some intriguing aspects regarding its solubility. Understanding solubility is crucial for various applications in chemical and pharmaceutical research, as it often dictates the compound's behavior in solution.

Factors Influencing Solubility

The solubility of chemical compounds is influenced by a number of factors, including:

  • Molecular Structure: The presence of functional groups such as hydroxyl (-OH) and acetyl (-COCH3) can enhance solubility in polar solvents.
  • Polarity: The overall polarity of the molecule affects its interaction with solvents. This compound contains polar groups that likely improve its solubility in water.
  • Temperature: Solubility can vary with temperature, often increasing as the temperature rises, affecting how the compound behaves in different environments.

Predicted Solubility

Due to its complex structure and the presence of polar functional groups, one might expect:

  • Increased solubility in polar solvents such as water or alcohols.
  • Reduced solubility in non-polar solvents like hexane or toluene.
  • A potential for forming stable complexes in solution due to the diverse functional groups present.

When evaluating the solubility of this compound, it is essential to conduct empirical testing under controlled conditions to ascertain its behavior in various solvent systems. As a general rule, the principle of "like dissolves like" applies, meaning the characteristics of the solvent will play a significant role in the overall solubility of the compound.


Interesting facts

Interesting Facts about (2S,4R,8S,11S,12R)-8-acetyl-12-fluoro-11-hydroxy-6,6,9,13-tetramethyl-5,7-dioxapentacyclo[10.8.0.02,9.04,8.013,18]icosa-14,17-dien-16-one

This compound is a fascinating example of the complexity and diversity found in organic chemistry. Its intricate structure illustrates the subtlety of stereochemistry, which plays a crucial role in determining the compound's properties and potential applications. Here are some captivating aspects of this compound:

  • Stereochemistry: Featuring multiple chiral centers denoted by the (S) and (R) configurations, this molecule exemplifies how stereochemistry is vital in pharmaceuticals, influencing interactions with biological targets.
  • Functional Groups: The presence of various functional groups, such as acetyl and hydroxy, suggests potential reactivity and biological activity, making it a candidate for further research in medicinal chemistry.
  • Potential Applications: Given its structural attributes, compounds like this one are often studied for their therapeutic properties, which may include anti-inflammatory or antitumor activities.
  • Complexity: The pentacyclic framework reveals the beauty of chemical molecules that can be derived from natural sources, particularly in the realm of terpenes and other secondary metabolites.

As a compound with multiple possible conformations and reactivity patterns, this molecule highlights the importance of depth in chemical synthesis and research. It serves as a prime example of how even small variations in structure can lead to significant changes in functionality. The study and understanding of such complexes are vital for advancing fields like organic synthesis, pharmacology, and materials science.

In conclusion, investigating compounds like this one opens doors to numerous scientific inquiries and innovations. As one might say, “The devil is in the details,” and appreciating these details can lead to breakthroughs in understanding complex molecular interactions.