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Camptothecin

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Identification
Molecular formula
C20H16N2O4
CAS number
7689-03-4
IUPAC name
(2S,4R,8S,12S)-11-hydroxy-8-(2-hydroxyacetyl)-6,6,9,13-tetramethyl-5,7-dioxapentacyclo[10.8.0.02,9.04,8.013,18]icosa-14,17-dien-16-one
State
State

Camptothecin is typically solid at room temperature.

Melting point (Celsius)
265.00
Melting point (Kelvin)
538.15
Boiling point (Celsius)
707.90
Boiling point (Kelvin)
981.05
General information
Molecular weight
348.35g/mol
Molar mass
348.3520g/mol
Density
1.2700g/cm3
Appearence

Camptothecin appears as a pale yellow crystalline solid. It can also present as a yellowish powder depending on its purity and source.

Comment on solubility

Solubility Insights

The compound (2S,4R,8S,12S)-11-hydroxy-8-(2-hydroxyacetyl)-6,6,9,13-tetramethyl-5,7-dioxapentacyclo[10.8.0.02,9.04,8.013,18]icosa-14,17-dien-16-one showcases intriguing solubility characteristics that can greatly influence its applications in various fields.

Considering the complex structure of the compound, its solubility can be impacted by numerous factors such as:

  • Molecular structure: The presence of multiple functional groups, especially hydroxyl (-OH) and acetyl (-COCH3) moieties, generally enhances solubility in polar solvents.
  • Polarity: The balance between hydrophobic and hydrophilic sections in the molecule affects solubility in water versus organic solvents.
  • Temperature and pH: Changes in these parameters can alter the solubility profile, often making it crucial to evaluate under specific conditions.

In general, compounds similar to this one often exhibit:

  1. Good solubility in polar solvents such as water, alcohols, and acetone.
  2. Lower solubility in non-polar solvents like hexane or benzene.
  3. Potentially variable solubility based on crystal form and purity.

As noted, the solubility of (2S,4R,8S,12S)-11-hydroxy-8-(2-hydroxyacetyl)-6,6,9,13-tetramethyl-5,7-dioxapentacyclo[10.8.0.02,9.04,8.013,18]icosa-14,17-dien-16-one may not be consistent across different environments, making it essential for researchers and practitioners to conduct further testing to determine the optimum conditions for its use. In conclusion, solubility plays a pivotal role in understanding how this compound can be effectively utilized in various chemical and pharmaceutical applications.

Interesting facts

Interesting Facts about (2S,4R,8S,12S)-11-Hydroxy-8-(2-Hydroxyacetyl)-6,6,9,13-Tetramethyl-5,7-Dioxapentacyclo[10.8.0.02,9.04,8.013,18]Icosa-14,17-Dien-16-One

This complex compound exemplifies the fascinating world of organic chemistry, particularly in the realm of natural products and their derivatives. Here are some key points to consider:

  • Natural Origin: Many compounds like this one are derived from natural sources, often showcasing intricate structures that play significant roles in biological systems.
  • Stereochemistry Importance: The specific stereochemistry indicated by its notation (2S, 4R, 8S, 12S) highlights the compound's chiral centers, which can greatly influence its biological activity and interactions with enzymes and receptors in the body.
  • Diverse Applications: Compounds with similar structures are frequently studied for various applications, including pharmaceuticals, agrochemicals, and biocatalysts, owing to their unique functional groups and structural properties.
  • Research Potential: The complexity of this compound presents numerous challenges and opportunities for researchers. Studies might explore its potential as a therapeutic agent, particularly in the fields of oncology or anti-inflammatory treatments.
  • Analytical Techniques: The characterization of such a compound often requires advanced analytical techniques such as NMR spectroscopy, mass spectrometry, and X-ray crystallography to elucidate its detailed structure and properties.

This compound is a testament to the intricate designs found in nature and underscores the importance of stereochemical configurations in determining the functionality of organic molecules. As researchers continue to uncover the secrets of such compounds, the possibilities for novel applications remain vast.

Synonyms
SCHEMBL1649865
AKOS026750047