Interesting facts
Interesting Facts about (2S,5R,6R)-6-[(2-ethoxynaphthalene-1-carbonyl)amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
This fascinating compound belongs to a unique class of molecules known for their complex structure and potential biological activities. Here are some intriguing insights:
- Stereochemistry: The compound possesses specific stereochemical configurations, denoted by (2S, 5R, 6R), which significantly influence its biological behavior and interactions at the molecular level. Stereochemistry is crucial in drug design, as different isomers can exhibit varying effects in biological systems.
- Thiazole Moiety: The chemical structure contains a thia (sulfur) atom integrated into its bicyclic framework. This thiazole-based framework can enhance the compound's ability to interact with biological targets, making it a point of interest in medicinal chemistry.
- Biological Relevance: Compounds that resemble this one often exhibit potent pharmacological properties. Research indicates that structurally similar compounds can function as antibacterial agents, enzyme inhibitors, or even exhibit anticancer activities.
- Carbonyl and Amino Groups: The presence of carbonyl and amino functional groups in the structure can facilitate hydrogen bonding and interactions with enzyme active sites, enhancing the compound's affinity for specific biological targets.
- Drug Design Insights: The complexity and diversity of substituents, such as the ethoxynaphthalene moiety, directly influence the pharmacodynamics and pharmacokinetics, representing a significant area for synthetic chemists to explore novel therapeutic agents.
In summary, the intricate design and biochemical potential of (2S,5R,6R)-6-[(2-ethoxynaphthalene-1-carbonyl)amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid make it a compelling subject for further research. Its unique attributes not only highlight the beauty of chemical synthesis but also underscore the significance of molecular geometry in developing effective pharmaceuticals.
Synonyms
nafcillin
Naphcillin
147-52-4
Nafcilina
Nafcilline
Nafcillinum
Nallpen
Nafcilin-1
Unipen
(2-Ethoxy-1-naphthyl)penicillin
Nafcilina [INN-Spanish]
Nafcilline [INN-French]
Nafcillinum [INN-Latin]
(2-ethoxy-1-naphthalenyl)penicillin
CHEBI:7447
(2S,5R,6R)-6-[(2-ethoxynaphthalene-1-carbonyl)amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
HSDB 3133
Penicillin, (2-ethoxy-1-naphthalenyl)-
UNII-4CNZ27M7RV
EINECS 205-690-9
4CNZ27M7RV
6-(2-ethoxy-1-naphthamido)penicillanic acid
Nafcillin (INN)
Penicillin, (2-ethoxy-1-naphthyl)-
BRN 0862393
4-Thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid, 6-(((2-ethoxy-1-naphthalenyl)carbonyl)amino)-3,3-dimethyl-7-oxo-, (2S-(2alpha,5alpha,6beta))-
DTXSID8023343
Naphthamidopenicillin
4-Thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid, 6-(2-ethoxy-1-naphthamido)-3,3-dimethyl-7-oxo-
NAFCILLIN [INN]
Nafcilina (INN-Spanish)
Nafcilline (INN-French)
Nafcillinum (INN-Latin)
Nafcillin [INN:BAN]
6beta-(2-ethoxynaphthalene-1-carboxamido)-2,2-dimethylpenam-3alpha-carboxylic acid
(2S,5R,6R)-6-(2-ethoxynaphthalene-1-amido)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
(2S,5R,6R)-6-{[(2-ethoxynaphthalen-1-yl)carbonyl]amino}-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
Nafcillin & VRC3375
(2s,5r,6r)-6-[(2-ethoxy-1-naphthoyl)amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
4-THIA-1-AZABICYCLO(3.2.0)HEPTANE-2-CARBOXYLIC ACID, 6-(((2-ETHOXY-1-NAPHTHALENYL)CARBONYL)AMINO)-3,3-DIMETHYL-7-OXO-, (2S,5R,6R)-
4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 6-[[(2-ethoxy-1-naphthalenyl)carbonyl]amino]-3,3-dimethyl-7-oxo-, (2S,5R,6R)-
nafcillina
(2S,5R,6R)-6-(((2-ethoxynaphthalen-1-yl)carbonyl)amino)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid
(2S,5R,6R)-6-((2-ethoxy-1-naphthoyl)amino)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid
(2S,5R,6R)-6-((2-ethoxynaphthalene-1-carbonyl)amino)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid
NAFCILLIN [MI]
NAFCILLIN [HSDB]
Prestwick0_000843
Prestwick1_000843
Prestwick2_000843
Prestwick3_000843
NAFCILLIN [VANDF]
Epitope ID:141583
NAFCILLIN [WHO-DD]
CHEMBL1443
SCHEMBL47797
BSPBio_000825
SPBio_002746
BPBio1_000909
DTXCID303343
GTPL10942
J01CF06
Ethoxynaphthamido Penicillin Sodium
GLXC-27807
BCP17447
HY-B0555
BDBM50103525
AKOS040744845
DB00607
(2S,5R,6R)-6-({[2-(ethyloxy)naphthalen-1-yl]carbonyl}amino)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
DA-55983
CS-0009511
C07250
D08242
EN300-24433472
Q1638852
BRD-K18574842-236-17-7
BRD-K18574842-323-03-3
BRD-K18574842-323-10-8
(2S-(2.ALPHA.,5.ALPHA.,6.BETA.))-6-(((2-ETHOXY-L-NAPHTHALENYL)CARBONYL)-AMINO)-3,3-DIMETHYL-7-OXO-4-THIA-1-AZABICYCLO(3.2.0)HEPTANE-2-CARBOXYLIC ACID
(2S-(2alpha,5alpha,6beta))-6-(((2-ETHOXY-L-NAPHTHALENYL)CARBONYL)-AMINO)-3,3-DIMETHYL-7-OXO-4-THIA-1-AZABICYCLO(3.2.0)HEPTANE-2-CARBOXYLIC ACID
205-690-9
4-THIA-1-AZABICYCLO(3.2.0)HEPTANE-2-CARBOXYLIC ACID, 6-(((2-ETHOXY-1-NAPHTHALENYL)CARBONYL)AMINO)-3,3-DIMETHYL-7-OXO-, (2S///
Solubility of (2S,5R,6R)-6-[(2-ethoxynaphthalene-1-carbonyl)amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
The solubility of this complex compound presents an intriguing challenge due to its multifaceted structure. Understanding the solubility is essential for its application in various fields. Here are some key points to consider:
In conclusion, the solubility of this compound can be quite variable and is largely influenced by its structural characteristics and the surrounding environment. As the famous saying goes, “Like dissolves like,” and this principle is pivotal when evaluating the solubility of such intricate chemical entities.