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Camptothecin

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Identification
Molecular formula
C20H16N2O4
CAS number
7689-03-4
IUPAC name
[(2S,5S,7S,8S,10R,13S)-2,13-diacetoxy-7,10-dihydroxy-8,12,15,15-tetramethyl-9-oxo-5-tricyclo[9.3.1.14,8]hexadeca-3,11-dienyl] (2R,3S)-3-(dimethylamino)-2-hydroxy-3-phenyl-propanoate
State
State

At room temperature, camptothecin is a solid compound, which is typically encountered as a crystalline powder. The powder is often compacted and sold as a more stable solid to ensure ease of handling and measurement in laboratory settings.

Melting point (Celsius)
274.00
Melting point (Kelvin)
547.15
Boiling point (Celsius)
650.00
Boiling point (Kelvin)
923.15
General information
Molecular weight
348.35g/mol
Molar mass
348.3530g/mol
Density
1.0700g/cm3
Appearence

Camptothecin typically appears as a pale yellow to yellow crystalline solid. It may also be present in crystalline powder form, depending on the source and processing method. The solid crystals usually have a distinctive, bright yellow hue.

Comment on solubility

Solubility of the Compound

The solubility of the compound C20H16N2O4, particularly known as the derivative of the tricyclic compound, can be intricate due to its complex structure and functional groups. Understanding the solubility characteristics involves several key factors:

  • Polarity: The presence of hydroxyl (-OH) groups contributes to the compound's polar nature, enhancing its interaction with polar solvents such as water.
  • Hydrophobic Regions: The hydrophobic tricyclic structure may limit its solubility in aqueous environments, leading to potential challenges when attempting to dissolve the compound in common solvents.
  • Solvent Interactions: Solubility may vary significantly depending on the choice of solvent. Non-polar solvents could facilitate better solubility for hydrophobic components, while polar solvents would work best for the more polar regions of the compound.
  • Temperature Effects: Temperature can also play a crucial role, as higher temperatures typically increase the solubility of solid compounds in liquids.

In summary, while the compound possesses functional groups that may enhance its solubility in polar solvents, its overall solubility is likely hindered by its hydrophobic characteristics. A thorough investigation into various solvent systems is recommended to ascertain the most favorable conditions for dissolution.

Interesting facts

Exploring the Compound: 2,13-diacetoxy-7,10-dihydroxy-8,12,15,15-tetramethyl-9-oxo-5-tricyclo[9.3.1.14,8]hexadeca-3,11-dienyl 3-(dimethylamino)-2-hydroxy-3-phenyl-propanoate

This fascinating compound, known for its complex structure and diverse functionalities, holds significant interest within both academic and pharmaceutical research fields. Here are some intriguing aspects:

  • Natural Origins: Many compounds like this one are derived from natural sources, often exhibiting remarkable biological activities.
  • Complexity and Stereochemistry: The compound features multiple stereogenic centers, contributing to its stereochemistry. This complexity can lead to variations in biological activity based on its three-dimensional arrangement.
  • Biological Significance: Compounds related to this class have been studied for their potential uses in drug development, particularly in the realm of anti-inflammatory and anti-cancer therapies.
  • Functional Groups: The presence of both acetoxy and dimethylamino functional groups highlights the compound's potential reactivity and interaction with various biological molecules, possibly enhancing its therapeutic properties.
  • Research Potential: With the ongoing research into compounds of similar structure, this compound presents a platform for developing new synthetic methodologies and understanding structure-activity relationships, which are vital in medicinal chemistry.

"The beauty of complex molecules lies in their ability to interact with biological systems in multifaceted ways."

This compound exemplifies how detailed chemical analysis can lead to advancements in medicine and a deeper understanding of biochemical processes. Its unique composition and characteristics make it a noteworthy subject for future studies and innovations in chemical sciences.