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Aldosterone

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Identification
Molecular formula
C21H28O5
CAS number
52-39-1
IUPAC name
(2S,5S,8R,9S,10S,13S,14S,17S)-17-hydroxy-2-(hydroxymethyl)-10,13-dimethyl-1,2,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydrocyclopenta[a]phenanthren-3-one
State
State

Aldosterone is solid at room temperature. It is typically handled as a crystalline powder in laboratories and in pharmaceutical preparations.

Melting point (Celsius)
174.00
Melting point (Kelvin)
447.15
Boiling point (Celsius)
220.00
Boiling point (Kelvin)
493.15
General information
Molecular weight
360.45g/mol
Molar mass
360.4440g/mol
Density
1.0643g/cm3
Appearence

Aldosterone is typically a white to off-white crystalline powder. It may appear colorless under certain conditions and usually does not have any distinct smell when pure.

Comment on solubility

Solubility of (2S,5S,8R,9S,10S,13S,14S,17S)-17-hydroxy-2-(hydroxymethyl)-10,13-dimethyl-1,2,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydrocyclopenta[a]phenanthren-3-one

The solubility of the compound (2S,5S,8R,9S,10S,13S,14S,17S)-17-hydroxy-2-(hydroxymethyl)-10,13-dimethyl-1,2,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydrocyclopenta[a]phenanthren-3-one can be intriguing due to its structural complexity. Here are some key points regarding its solubility characteristics:

  • Polarity: The presence of hydroxyl (-OH) groups generally suggests increased polarity, which may enhance solubility in polar solvents like water.
  • Hydrophobic Regions: The compound's large hydrocarbon segments can hinder its overall water solubility, making it more soluble in organic solvents such as ethanol or acetone.
  • Solvent Compatibility: It is anticipated that the compound might exhibit solubility in:
    • Non-polar solvents: Hexane, cyclohexane
    • Polar solvents: Methanol, dimethyl sulfoxide (DMSO)
  • Temperature Dependence: Solubility may increase with temperature, particularly in organic solvents.

As is often the case with complex organic molecules, the solubility can be highly context-dependent, varying with factors such as temperature, pH, and the presence of other solutes. Always refer to experimental data for precise solubility information.

Interesting facts

Interesting Facts about the Compound: 17-Hydroxy-2-(hydroxymethyl)-10,13-dimethyl-1,2,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydrocyclopenta[a]phenanthren-3-one

This complex organic compound belongs to a family of compounds known as **steroids**, characterized by their multi-ring structure. The compound exhibits fascinating stereochemistry, reflected in its multiple stereocenters, which can influence its biological activity and interactions with various enzymes and receptors in the body.

Key Highlights:

  • Steroid Backbone: The compound contains a characteristic steroid structure, making it an interesting subject for studies related to **hormonal activity** and **drug design**.
  • Hydroxyl Groups: The presence of hydroxyl groups (–OH) suggests potential for extensive hydrogen bonding, which can affect its solubility and reactivity profiles.
  • Biological Relevance: Compounds similar to this one have been studied for their roles in various physiological processes, including metabolism and reproduction.
  • Synthesis Potential: With multiple functional groups and chiral centers, synthetic chemists may explore innovative methods for its synthesis or modification, potentially leading to novel therapeutic applications.

Moreover, the complexity of this compound's structure lends itself to various applications in medicinal chemistry, particularly in developing new drugs targeting conditions driven by steroidal mechanisms. As noted by researchers, compounds with similar frameworks often serve as valuable leads in the search for **antitumoral**, **antiviral**, and other **pharmacological** activities.

In conclusion, the intricate structure and potential biological significance of this compound make it an intriguing topic for further exploration in the fields of medicinal and organic chemistry.

Synonyms
566-52-9
17beta-Hydroxy-2alpha-(hydroxymethyl)-5alpha-androstan-3-one
NSC54341
NIOSH/BV8058700
(2S,5S,8R,9S,10S,13S,14S,17S)-17-hydroxy-2-(hydroxymethyl)-10,13-dimethyl-1,2,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydrocyclopenta[a]phenanthren-3-one
BV80587000
2-alpha-Hydroxymethyl-17-beta-hydroxyandrostan-3-one
17-beta-Hydroxy-2-alpha-(hydroxymethyl)androstan-3-one
Androstan-3-one, 17-beta-hydroxy-2-alpha-(hydroxymethyl)-
NSC 54341
2-alpha-Hydroxymethyl-17-beta-hydroxy-5-alpha-androstan-3-one
5-alpha-ANDROSTAN-3-ONE, 2-alpha-(HYDROXYMETHYL)-17-beta-HYDROXY-
CHEBI:79557
DTXSID20972038
NSC-54341
17-Hydroxy-2-(hydroxymethyl)androstan-3-one
Q27148670