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Rolicyclidine

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Identification
Molecular formula
C22H26N2
CAS number
2201-22-3
IUPAC name
3-[[1-(2-phenylethyl)-4-piperidyl]methyl]-1H-indole
State
State

Rolicyclidine is usually a solid at room temperature.

Melting point (Celsius)
158.00
Melting point (Kelvin)
431.15
Boiling point (Celsius)
455.50
Boiling point (Kelvin)
728.65
General information
Molecular weight
322.46g/mol
Molar mass
322.4590g/mol
Density
1.1400g/cm3
Appearence

Rolicyclidine is typically found as a white crystalline powder.

Comment on solubility

Solubility of 3-[[1-(2-phenylethyl)-4-piperidyl]methyl]-1H-indole

The solubility of 3-[[1-(2-phenylethyl)-4-piperidyl]methyl]-1H-indole is an intriguing topic, particularly due to its complex structure. Understanding its solubility can be approached through various dimensions:

  • Polarity: This compound's solubility is highly influenced by its polarity. The presence of the indole moiety generally increases hydrophobic characteristics, potentially leading to limited solubility in water.
  • Solvent Interaction: It is expected to exhibit different solubility profiles in organic solvents compared to aqueous environments. Common solvents such as ethanol and DMSO may enhance solubility due to compatibility with the compound’s hydrophobic regions.
  • Temperature Impact: As is common with many organic compounds, solubility typically increases with temperature. Thus, warming the solvent may facilitate better dissolution.

In practice, it has been noted that "solubility can be a barrier to drug design and formulation, affecting bioavailability and efficacy." Hence, conducting thorough solubility testing in various solvents at different temperatures can provide insightful data for both pharmaceutical applications and further research into this compound.

To summarize:

  1. Limited solubility in water due to hydrophobic regions.
  2. Enhanced solubility in organic solvents like ethanol.
  3. Temperature increases favorably impact solubility.
Interesting facts

Interesting Facts about 3-[[1-(2-phenylethyl)-4-piperidyl]methyl]-1H-indole

3-[[1-(2-phenylethyl)-4-piperidyl]methyl]-1H-indole, a fascinating compound in the realm of medicinal chemistry, showcases intriguing biological relevance and potential therapeutic applications. Here are some engaging insights:

  • Structure & Function: This compound features an indole core, a structure commonly found in a variety of natural products and pharmaceuticals. The indole ring is known for its ability to participate in diverse biochemical interactions, including binding to receptors.
  • Pharmacological Interest: Compounds like this one are often explored for their neuroactive properties, owing to their structural motifs that can interact with neurotransmitter systems. The piperidine and phenylethyl groups can enhance its affinity for specific receptors in the brain.
  • Potential Applications: Researchers are investigating this compound’s potential as an antidepressant or anxiolytic agent. Its unique structure may provide a pathway for developing new treatment strategies for mood disorders.
  • Innovation in Synthesis: The synthesis of such complex molecules often involves multi-step organic reactions and can serve as a testament to advances in synthetic chemistry techniques. Developing effective synthetic routes can reveal insights into stereochemistry and reaction mechanisms.
  • Interdisciplinary Connections: Understanding this compound requires knowledge across various scientific domains, including organic chemistry, pharmacology, and biochemistry. It exemplifies how chemical knowledge integrates with biological systems.

Studying compounds like 3-[[1-(2-phenylethyl)-4-piperidyl]methyl]-1H-indole not only enhances our understanding of chemical interactions but also opens doors for innovative therapeutic approaches. As one researcher aptly put it, "Every structure tells a story, and in chemistry, these stories can lead to breakthroughs that change lives."

Synonyms
BRN 0551133
INDOLE, 3-(1-PHENETHYL-4-PIPERIDYLMETHYL)-
3515-53-5
3-(N-Phenylethyl-4-piperidinomethyl) indole
DTXSID70188647
DTXCID30111138
5-23-07-00421 (beilstein handbook reference)
3-{[1-(2-Phenylethyl)-4-piperidinyl]methyl}-1H-indole