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Droperidol hydrochloride

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Identification
Molecular formula
C22H25ClN2O2
CAS number
548-73-2
IUPAC name
3-(1-benzyl-4-piperidyl)-3-phenyl-piperidine-2,6-dione;hydrochloride
State
State

At room temperature, droperidol hydrochloride is typically a solid compound.

Melting point (Celsius)
97.00
Melting point (Kelvin)
370.00
Boiling point (Celsius)
310.00
Boiling point (Kelvin)
583.00
General information
Molecular weight
379.87g/mol
Molar mass
379.8720g/mol
Density
1.3500g/cm3
Appearence

Droperidol hydrochloride is a white to slightly yellowish crystalline powder. It is hygroscopic and highly soluble in water, giving a clear, colorless solution.

Comment on solubility

Solubility of 3-(1-benzyl-4-piperidyl)-3-phenyl-piperidine-2,6-dione hydrochloride

The solubility of 3-(1-benzyl-4-piperidyl)-3-phenyl-piperidine-2,6-dione hydrochloride is crucial for its applications in pharmacology and research. Understanding the solubility properties can be summarized as follows:

  • Solvent Compatibility: This compound generally exhibits better solubility in polar solvents such as water and ethanol, particularly due to the presence of the hydrochloride salt which enhances its solubility in aqueous solutions.
  • Temperature Influence: The solubility tends to increase with rising temperature, a common trait seen in many organic compounds, making dissolution easier at higher temperatures.
  • pH Dependency: The solubility can also be affected by the pH of the solution, with acidic conditions typically favoring greater solubility due to the protonation of the nitrogen atoms within the molecule.

In practical applications, this compound’s solubility characteristics can be leveraged for various formulations:

  1. Injectable Solutions: High solubility in aqueous solutions is beneficial for injectable formulations, ensuring proper bioavailability.
  2. Oral Forms: Understanding the solubility can guide the development of oral dosage forms, affecting absorption rates and therapeutic effectiveness.
  3. Stability Considerations: It's essential to consider how solubility changes with concentration which can impact stability, particularly during long-term storage.

In summary, the solubility of 3-(1-benzyl-4-piperidyl)-3-phenyl-piperidine-2,6-dione hydrochloride significantly influences its practical applications and efficacy. Ensuring optimal solubility conditions is vital for maximizing its potential in scientific and medical fields.

Interesting facts

Interesting Facts about 3-(1-benzyl-4-piperidyl)-3-phenyl-piperidine-2,6-dione; hydrochloride

This compound, often referred to as a *piperidine derivative*, showcases a remarkable structure that indicates potential pharmacological activities. It is part of a larger class of compounds that possess diverse therapeutic properties.

Key Characteristics:

  • Complex Structure: The molecule features multiple ring systems and functional groups, which may contribute to its unique interactions with biological targets.
  • Pharmacological Relevance: Given its piperidine framework, this compound holds promise in medicinal chemistry, potentially acting on central nervous system pathways.
  • Versatile Applications: Compounds similar to this have been studied for their roles in treating neurological disorders and have shown significant promise in various animal models.

As noted by many researchers, “Structural diversity is key to developing new therapeutics.” The presence of the benzyl and phenyl groups may enhance the lipophilicity of the compound, suggesting increased cellular permeability. This characteristic is critical in drug design, as it can influence the bioavailability of pharmacological agents.

Research Directions:

  • Biological Studies: Further research is needed to elucidate the specific mechanisms of action and therapeutic effects of this compound.
  • Comparative Analysis: Comparing this compound to other derivatives might reveal insights into optimizing its efficacy and safety profiles.
  • Potential Synergies: Investigating its combination with other drugs could pave the way for innovative treatment strategies.

In conclusion, the exploration of 3-(1-benzyl-4-piperidyl)-3-phenyl-piperidine-2,6-dione; hydrochloride exemplifies the fascinating intersection of chemistry, biology, and pharmacology. Its intricate molecular architecture not only piques the curiosity of chemists but also emphasizes the ongoing quest in drug discovery for *novel therapeutic agents*.

Synonyms
BENZETIMIDE HYDROCHLORIDE
5633-14-7
Benzetimide HCl
Dioxatrine
Benzetimide hydrochloride [USAN]
McN-JR4929
McN-JR 4929
UNII-V6ERX20PHB
V6ERX20PHB
Dioxatrine (TN)
MCN-JR-4929-11
EINECS 227-072-8
JANSSEN R 492
JANSSEN-R-492
JANSSEN R 4929
R 4929
2-(1-Benzyl-4-piperidyl)-2-phenylglutarimide monohydrochloride
dl-2-(1-Benzyl-4-piperidyl)-2-phenylglutarimide hydrochloride
Benzetimide hydrochloride (USAN)
dl-1-Benzyl-4-(2,6-dioxo-3-phenyl-3-piperidyl)piperidine hydrochloride
(3,4'-Bipiperidine)-2,6-dione, 3-phenyl-1'-(phenylmethyl)-, monohydrochloride
BENZETIMIDE HYDROCHLORIDE [MI]
Glutarimide, 2-(1-benzyl-4-piperidyl)-2-phenyl-, hydrochloride
227-072-8
Benzetimide (hydrochloride)
Spasmentral
5633-14-7 (HCl)
3-(1-benzylpiperidin-4-yl)-3-phenylpiperidine-2,6-dione,hydrochloride
3-Phenyl-1'-(phenylmethyl)-[3,4'-bipiperidine]-2,6-dione Hydrochloride; 2-(1-Benzyl-4-piperidyl)-2-phenyl-glutarimide Monohydrochloride; 3-Phenyl-1'-(phenylmethyl)-[3,4'-bipiperidine]-2,6-dione Monohydrochloride; R 4929; Spasmentral
Benzetimide Hydrchloride
MLS001201802
SCHEMBL635393
CHEMBL545131
HY-B1547A
XSOOSXRNMDUWEM-UHFFFAOYSA-N
DTXSID101036320
GLXC-21643
BCP11991
BCP28424
3-Phenyl-1'-(phenylmethyl)(3,4'-bipiperidine)-2,6-dione monohydrochloride
AKOS025402010
CS-5308
AC-28141
DA-71381
MS-26755
SMR000718634
NS00080966
D03087
F85330
Q27291593
Benzetimide HCl; R4929 HCl; R 4929 HCl; R-4929 HCl
3-(1-benzylpiperidin-4-yl)-3-phenylpiperidine-2,6-dione;hydrochloride
[3,4'-Bipiperidine]-2,6-dione,3-phenyl-1'-(phenylmethyl)-, hydrochloride (1:1)