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3-Benzoate, 1-benzyl-4-(3-indolylmethyl)piperidine, hydrochloride

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Identification
Molecular formula
C22H27ClN2O
IUPAC name
3-[(1-benzylpiperidin-1-ium-4-yl)methyl]-5-methoxy-1H-indole;chloride
State
State

At room temperature, the compound is in a solid state. This solid nature makes it suitable for storage in powdered form, which facilitates its measurement and handling in various applications.

Melting point (Celsius)
160.00
Melting point (Kelvin)
433.15
Boiling point (Celsius)
350.00
Boiling point (Kelvin)
623.15
General information
Molecular weight
412.96g/mol
Molar mass
412.9600g/mol
Density
1.2500g/cm3
Appearence

The compound typically appears as a white solid. The coloration can slightly vary if impurities are present. As a solid, it generally forms into crystalline structures.

Comment on solubility

Solubility of 3-[(1-benzylpiperidin-1-ium-4-yl)methyl]-5-methoxy-1H-indole;chloride

The solubility of the compound 3-[(1-benzylpiperidin-1-ium-4-yl)methyl]-5-methoxy-1H-indole;chloride is influenced by several factors, including the presence of the charged piperidinium moiety and the overall hydrophobic characteristics of the indole structure. Here are some key points regarding its solubility:

  • Polarity: The presence of the piperidin-1-ium positively charged group contributes to the overall polarity of the compound, which may enhance its solubility in polar solvents.
  • Solvent Interactions: This compound is likely to show good solubility in water and other polar protic solvents due to hydrogen bonding capabilities, while its hydrophobic indole moiety may limit solubility in nonpolar solvents.
  • Salt Formation: As a chloride salt, this compound may exhibit improved solubility characteristics compared to its free base form, especially in aqueous media.
  • Temperature Dependence: The solubility could also be affected by temperature, often increasing with elevated temperatures, a common trend in many organic compounds.

In summary, while this compound shows promising solubility in polar solvents due to its ionic character and molecular structure, factors such as solvent choice, temperature, and concentration will significantly impact its solubility behavior. Understanding these aspects is crucial for applications involving this chemical.

Interesting facts

Interesting Facts about 3-[(1-benzylpiperidin-1-ium-4-yl)methyl]-5-methoxy-1H-indole;chloride

The compound 3-[(1-benzylpiperidin-1-ium-4-yl)methyl]-5-methoxy-1H-indole;chloride, often abbreviated for convenience, is a fascinating product of organic synthesis with significant implications in various fields, particularly medicinal chemistry.

Key Features:

  • Structure: This compound includes an indole moiety, which is a vital structure found in many biologically active molecules. Indoles play a key role in pharmacology due to their diverse chemical properties and ability to engage in various biological interactions.
  • Active Groups: The presence of the benzylpiperidinium group adds quaternary amine characteristics, which can enhance solubility and bioavailability compared to non-quaternized counterparts. Such substitutions are pivotal in drug design.
  • Potential Applications: Compounds like this one are often explored for their neuropharmacological activities, with potential uses in treating disorders related to the central nervous system. Studies suggest compounds of this nature may interact with neurotransmitter receptors, impacting mood and cognition.
  • Synthetic Routes: The synthesis of this compound involves intricate organic reactions, which can include nucleophilic substitutions and multi-step procedures to construct the complex framework effectively.

Scientific Significance:

As a part of ongoing research in medicinal chemistry, compounds like 3-[(1-benzylpiperidin-1-ium-4-yl)methyl]-5-methoxy-1H-indole;chloride embody the quest for new therapeutic agents. Their study is not just confined within the laboratory but extends to potential real-world implications in pharmacotherapy.

Moreover, “The future of pharmaceutical compounds lies in understanding their intricate structures and functional capabilities,” emphasizes a renowned chemist. It is through such investigations that we can uncover the therapeutic potential that these complex molecules offer.

Final Thoughts:

With its unique structure and promising biological activities, this compound serves as a prime example of how chemical innovation can lead to breakthroughs in medicine. Continued exploration and research into its properties could lead to the development of novel therapeutic agents that may significantly improve patient outcomes.

Synonyms
5-Methoxy-3-(N-benzyl-4-piperidinomethyl)indole hydrochloride
3515-59-1
INDOLE, 3-(1-BENZYL-4-PIPERIDYLMETHYL)-5-METHOXY-, HYDROCHLORIDE