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Tiotropium Bromide

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Identification
Molecular formula
C19H22BrNO4S2
CAS number
136310-93-5
IUPAC name
3-(1-carbamoyl-3,3-dimethyl-2-benzothiophen-1-yl)propyl-dimethyl-ammonium;chloride
State
State
At room temperature, Tiotropium Bromide is typically in a solid state, often found as a white to off-white crystalline powder. For medicinal use, it is commonly prepared in a device for inhalation.
Melting point (Celsius)
228.00
Melting point (Kelvin)
501.15
Boiling point (Celsius)
260.00
Boiling point (Kelvin)
533.15
General information
Molecular weight
472.43g/mol
Molar mass
472.4320g/mol
Density
1.3510g/cm3
Appearence

Tiotropium Bromide, commonly used in its bromide form, appears as a white crystalline powder. It is often provided as a pharmaceutical aerosol or in the form of inhalation capsules. The material is stable under recommended storage conditions and does not have any color or distinctive odor.

Comment on solubility

Solubility of 3-(1-carbamoyl-3,3-dimethyl-2-benzothiophen-1-yl)propyl-dimethyl-ammonium;chloride

The solubility of 3-(1-carbamoyl-3,3-dimethyl-2-benzothiophen-1-yl)propyl-dimethyl-ammonium;chloride can be influenced by several factors. Understanding its characteristics is essential for applications in various chemical processes. Below are some key points regarding its solubility:

  • Solvent Interaction: This compound is likely to be more soluble in polar solvents due to its ammonium chloride structure, which typically forms strong interactions with water molecules.
  • Temperature Effects: Like many ionic compounds, the solubility might increase with temperature. Higher temperatures can enhance the kinetic energy, leading to better dissolution rates.
  • Hydrophobic and Hydrophilic Balance: Given the structural components such as the benzothiophene moiety, the compound has both hydrophobic and hydrophilic characteristics. This balance affects how it interacts with different solvents.
  • pH Dependence: The solubility could also be affected by the pH of the solution, as ionization states change with different pH levels.
  • Concentration Effects: Higher concentrations may lead to saturation, impacting the solubility equilibrium.

In conclusion, while the solubility of 3-(1-carbamoyl-3,3-dimethyl-2-benzothiophen-1-yl)propyl-dimethyl-ammonium;chloride may be favorable in polar solvents, its solubility characteristics are complex and depend on environmental conditions and solvent interactions. Therefore, additional experiments are often required to quantify its solubility under specific conditions.

Interesting facts

Interesting Facts About 3-(1-Carbamoyl-3,3-dimethyl-2-benzothiophen-1-yl)propyl-dimethyl-ammonium; chloride

This unique chemical compound belongs to the category of quaternary ammonium salts, which are known for their distinctive properties and applications. Its molecular structure reveals an intriguing combination of organic and inorganic motifs, making it a subject of interest.

Key Features:

  • Biological Relevance: Compounds similar in structure to this one have been investigated for their potential pharmaceutical applications, especially in areas focusing on neuroprotection and antimicrobial activity.
  • Synthetic Utility: Its synthesis involves specific reaction pathways that demonstrate fundamental concepts in organic chemistry, such as nucleophilic substitution, showcasing the versatility of ammonium compounds.
  • Therapeutic Potential: Research into carboxamide derivatives suggests that modifications can lead to improved biological activity, hinting at the importance of this compound in medicinal chemistry.

According to researchers, "the fascinating interplay between the non-aromatic and aromatic regions of such compounds often dictates their overall reactivity and interaction with biological systems." This underscores the significance of studying compounds like 3-(1-carbamoyl-3,3-dimethyl-2-benzothiophen-1-yl)propyl-dimethyl-ammonium in the quest for new therapeutic agents.

Applications:

  • Antimicrobial surfaces in healthcare settings
  • Potential applications in drug delivery systems
  • Research into novel therapeutic agents

With the ever-evolving landscape of chemical research, compounds such as 3-(1-carbamoyl-3,3-dimethyl-2-benzothiophen-1-yl)propyl-dimethyl-ammonium; chloride open new avenues for exploration. Understanding their structure and behavior can lead to breakthroughs in various scientific fields.

Synonyms
LU 5-040 hydrochloride
26106-14-9
1,3-Dihydro-3,3-dimethyl-1-(3-(dimethylamino)propyl)benzo(c)thiophene-1-carboxamide HCl
Benzo(c)thiophene-1-carboxamide, 1,3-dihydro-3,3-dimethyl-1-(3-(dimethylamino)propyl)-, hydrochloride
RefChem:351418