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Isatin

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Identification
Molecular formula
C8H5NO2
CAS number
491-61-6
IUPAC name
3-(1-isoquinolylmethyleneamino)-1-(methylamino)isothiourea
State
State

Solid at room temperature.

Melting point (Celsius)
203.00
Melting point (Kelvin)
476.15
Boiling point (Celsius)
306.00
Boiling point (Kelvin)
579.15
General information
Molecular weight
147.12g/mol
Molar mass
147.1150g/mol
Density
1.4948g/cm3
Appearence

The compound typically appears as yellow to orange crystalline powder.

Comment on solubility

Solubility of 3-(1-isoquinolylmethyleneamino)-1-(methylamino)isothiourea

The solubility of 3-(1-isoquinolylmethyleneamino)-1-(methylamino)isothiourea can be influenced by several factors, which are essential to consider for its practical applications.


Key Factors Affecting Solubility:

  • Polarity: The presence of polar functional groups can significantly enhance solubility in polar solvents.
  • Temperature: Generally, increasing temperature can improve solubility, but this can vary based on the compound in question.
  • pH Level: The ionization state of the compound can change with pH, affecting solubility in aqueous environments.
  • Solvent Choice: Solubility can vary dramatically depending on whether the solvent is organic or aqueous.

In the case of this specific isothiourea derivative, it is often expected to exhibit limited solubility in water due to its larger organic moieties. However, solubility in various organic solvents may be more favorable. It's important to conduct empirical tests to determine its precise solubility characteristics.


As a general observation, quoting a common saying in chemistry, "Like dissolves like", can be particularly relevant when assessing the solubility of this compound in various media.

Interesting facts

Interesting Facts About 3-(1-isoquinolylmethyleneamino)-1-(methylamino)isothiourea

3-(1-isoquinolylmethyleneamino)-1-(methylamino)isothiourea is a fascinating compound that bridges the realms of organic chemistry and biochemistry. Here are some intriguing insights about it:

  • Pharmacological Potential: This compound is of interest in medicinal chemistry due to its potential therapeutic effects, particularly in the area of cancer research and drug development.
  • Structure-Activity Relationship: The presence of the isoquinoline moiety may enhance the bioactivity of this compound, making it a valuable subject for studies on structure-activity relationships (SAR).
  • Synthesis Complexity: The synthesis of this compound involves intricate organic reactions, contributing to a deeper understanding of thiourea derivatives and their reactivity.
  • Role of Isothioureas: Isothioureas are known for their ability to serve as bioisosteres, and this compound can potentially mimic other pharmacophores, broadening its applicability in drug design.
  • Research Applications: Researchers may explore the compound’s implications in enzyme inhibition, as its structural characteristics suggest it could interact favorably with various biological targets.

As we delve deeper into the study of 3-(1-isoquinolylmethyleneamino)-1-(methylamino)isothiourea, we uncover a wealth of possibilities that underscore the significance of small organic molecules in advancing medical science. This compound is a testament to how chemistry can lead to groundbreaking discoveries in health and medicine.