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3-[(1-methyl-3-piperidyl)methyl]-1H-indole

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Identification
Molecular formula
C16H20N2
CAS number
93957-51-0
IUPAC name
3-[(1-methyl-3-piperidyl)methyl]-1H-indole
State
State

3-[(1-methyl-3-piperidyl)methyl]-1H-indole is typically found as a solid at room temperature. It is usually not volatile, indicating its stability in solid form at ambient conditions.

Melting point (Celsius)
129.00
Melting point (Kelvin)
402.15
Boiling point (Celsius)
365.00
Boiling point (Kelvin)
638.15
General information
Molecular weight
240.35g/mol
Molar mass
240.3460g/mol
Density
1.0780g/cm3
Appearence

The compound 3-[(1-methyl-3-piperidyl)methyl]-1H-indole typically appears as a crystalline solid. Its color may vary depending on the level of purity and the presence of any impurities. Generally, pure samples will have a homogeneous texture.

Comment on solubility

Solubility of 3-[(1-methyl-3-piperidyl)methyl]-1H-indole

The solubility of 3-[(1-methyl-3-piperidyl)methyl]-1H-indole in various solvents can greatly influence its applications in pharmaceuticals and other chemical processes. Generally, solubility is determined by several factors, including molecular structure, polarity, and the presence of functional groups.

Key Factors Affecting Solubility:

  • Polarity: The presence of polar groups within the molecule can enhance solubility in polar solvents, whereas nonpolar characteristics may favor solubility in organic, nonpolar solvents.
  • Hydrogen Bonding: The ability to form hydrogen bonds typically increases solubility in aqueous solutions.
  • Molecular Weight: Higher molecular weight compounds may have reduced solubility due to increased van der Waals forces.

For 3-[(1-methyl-3-piperidyl)methyl]-1H-indole, solubility testing in water and various organic solvents is essential. The indole structure itself, being aromatic, is known for moderate solubility, while the piperidine moiety may influence interactions with solvents significantly. “Like dissolves like” is a maxim that can be applied here, meaning polar solvents would better dissolve polar compounds while nonpolar solvents work well with nonpolar substances.

In summary, understanding the solubility profile of 3-[(1-methyl-3-piperidyl)methyl]-1H-indole is crucial for optimizing its use in various applications. Ongoing research may yield more specific solubility data relevant to its practical applications.

Interesting facts

Interesting Facts about 3-[(1-methyl-3-piperidyl)methyl]-1H-indole

3-[(1-methyl-3-piperidyl)methyl]-1H-indole, often referred to in research circles as a significant pharmacophore, is a fascinating compound with diverse biological implications. Here are some compelling insights:

  • Structural Diversity: This compound features an indole ring—a key structure in many natural products and biologically active molecules. The indole framework is known for its role in numerous biochemical processes and its presence in various medications.
  • Biological Relevance: The substitution of the indole with a piperidine moiety significantly enhances the compound's interaction with biological systems. Compounds with these structural characteristics are often investigated as potential therapeutics, especially in the realms of psycho-pharmacology.
  • Research Interest: Due to its potential as a receptor ligand, this compound is a point of interest in drug development for treating neurological disorders, as it acts on neurotransmitter systems. It's fascinating how a simple modification in molecular structure can lead to substantial changes in pharmacological activity!
  • Synthesis Challenges: The synthesis of such compounds can be challenging, often requiring multi-step reactions and careful purification. Understanding these synthetic pathways is critical for chemists aiming to produce these valuable compounds efficiently.
  • Potential Applications: Beyond psychiatric applications, research suggests that derivatives of this compound may be explored for use in treating conditions such as anxiety, depression, and even chronic pain.
  • Quote to Remember: As noted by researchers, "The indole moiety is a versatile building block in medicinal chemistry, facilitating many therapeutic interactions." This underscores the importance of compounds like 3-[(1-methyl-3-piperidyl)methyl]-1H-indole in modern pharmacology.

In summary, 3-[(1-methyl-3-piperidyl)methyl]-1H-indole is not just a chemical entity, but a pivotal player in the exploration of new drugs that may improve our understanding and treatment of complex health issues. The intersection of its unique structure and biological capabilities continues to captivate scientists in the field.

Synonyms
INDOLE, 3-(1-METHYL-3-PIPERIDYLMETHYL)-
5595-00-6
1-Methyl-3-skatylpiperidine
BRN 1576138
3-[(1-methylpiperidin-3-yl)methyl]-1H-indole
DTXSID80971360