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3-(1-methyl-3-propyl-pyrrolidin-3-yl)phenol

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Identification
Molecular formula
C14H21NO
CAS number
148832-19-9
IUPAC name
3-(1-methyl-3-propyl-pyrrolidin-3-yl)phenol
State
State

This chemical generally exists as a liquid at room temperature.

Melting point (Celsius)
65.00
Melting point (Kelvin)
338.15
Boiling point (Celsius)
290.00
Boiling point (Kelvin)
563.15
General information
Molecular weight
219.33g/mol
Molar mass
219.3260g/mol
Density
1.0600g/cm3
Appearence

This compound typically appears as a colorless to pale yellow oil. It might show a viscous consistency due to its molecular structure and has aromatic properties owing to the phenol group.

Comment on solubility

Solubility of 3-(1-methyl-3-propyl-pyrrolidin-3-yl)phenol

The solubility of 3-(1-methyl-3-propyl-pyrrolidin-3-yl)phenol, a complex organic compound, is influenced by its unique structural characteristics. To understand its solubility, we can consider several key factors:

  • Polarity: Solubility is often predicted by a compound's polarity. 3-(1-methyl-3-propyl-pyrrolidin-3-yl)phenol possesses both hydrophilic and hydrophobic portions, which could lead to variable solubility in polar and non-polar solvents.
  • Hydrogen Bonding: The presence of hydroxyl (-OH) group contributes to its ability to form hydrogen bonds, potentially increasing solubility in water.
  • Alkyl Side Chains: The alkyl groups (methyl and propyl) introduce hydrophobic characteristics, which can reduce solubility in polar solvents like water, but may increase solubility in organic solvents.

Based on these factors, it could be stated that:

  1. Water Solubility: The compound may have limited solubility in water due to the balance of polar (hydroxyl group) and non-polar (alkyl chains) segments.
  2. Organic Solvent Solubility: It is likely more soluble in organic solvents, where the hydrophobic interactions can be favorable.

In conclusion, the solubility of 3-(1-methyl-3-propyl-pyrrolidin-3-yl)phenol is a nuanced topic, exhibiting both polar and non-polar characteristics that dictate its behavior in various solvents. As with many compounds, the phrase "like dissolves like" holds considerable relevance when predicting solubility outcomes.

Interesting facts

Interesting Facts about 3-(1-methyl-3-propyl-pyrrolidin-3-yl)phenol

3-(1-methyl-3-propyl-pyrrolidin-3-yl)phenol, often referenced in medicinal chemistry and pharmacology, presents a fascinating molecular framework with potential applications in various therapeutic areas. This compound can be studied through several engaging aspects:

1. Structure and Design

  • Hybrid Nature: This compound features a phenolic structure combined with a pyrrolidine ring. Such hybridization can influence both biological activity and physicochemical properties.
  • Substituent Diversity: The inclusion of a methyl and propyl group on the pyrrolidine moiety enhances lipophilicity, potentially affecting the compound's permeability and distribution in biological systems.

2. Biological Activity

  • Potential Therapeutics: Compounds with similar structures are often investigated for their abilities to function as agonists or antagonists at various receptors, which can lead to the development of new drugs.
  • Neuroactivity: Research in this area may reveal its role in modulating neurotransmitter systems, offering insights into treatments for neuropsychiatric disorders.

3. Synthetic Strategies

The synthesis of this compound often involves:

  • Utilization of selective reactions to build the pyrrolidine ring.
  • Methods that allow for the careful introduction of different substituents at strategic positions on the aromatic ring.

4. Research Trends

With advancements in analytical techniques, ongoing studies aim to:

  • Examine the compound's interaction with various biological targets.
  • Understand how slight modifications can lead to significant changes in activity.

As scientists continue to probe the complexities of 3-(1-methyl-3-propyl-pyrrolidin-3-yl)phenol, it stands as an exemplary model of how organic chemistry can intertwine with pharmacology, leading to groundbreaking discoveries.

Synonyms
PROFADOL
428-37-5
Profadol, (+)-
Dl-profadol
m-(1-Methyl-3-propyl-3-pyrrolidinyl)phenol
9TM4MXU27E
Phenol, m-(1-methyl-3-propyl-3-pyrrolidinyl)-
Profadol, (-)-
3-(m-Hydroxyphenyl)-1-methyl-3-propylpyrrolidine
UNII-9TM4MXU27E
41GDG43FTT
Pyrrolidine, 3-(m-hydroxyphenyl)-1-methyl-3-propyl-
89XH4S010S
CI 572
Phenol, 3-(1-methyl-3-propyl-3-pyrrolidinyl)-, (+)-
Phenol, m-(1-methyl-3-propyl-3-pyrrolidinyl)-, (+)-
13104-69-3
Phenol, 3-(1-methyl-3-propyl-3-pyrrolidinyl)-, (-)-
Phenol, m-(1-methyl-3-propyl-3-pyrrolidinyl)-, (-)-
dl-Profadol; m-(1-Methyl-3-propyl-3-pyrrolidinyl)phenol
Profadolum
Profadol [INN:BAN]
Profadolum [INN-Latin]
13104-68-2
UNII-41GDG43FTT
BRN 1373919
PROFADOL [INN]
3-(1-methyl-3-propylpyrrolidin-3-yl)phenol
PROFADOL [WHO-DD]
CI-572 FREE BASE
SCHEMBL160670
UNII-89XH4S010S
A-2205 FREE BASE
CHEMBL161204
DTXSID30861924
VFUGCQKESINERB-UHFFFAOYSA-N
NS00114090
3-(1-Methyl-3-propyl-3-pyrrolidinyl)phenol #
m-(1-Methyl-3-propyl-pyrrolidin-3-yl)-phenol
Q7247891
PHENOL, 3-(1-METHYL-3-PROPYL-3-PYRROLIDINYL)-