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O-Desmethyltramadol

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Identification
Molecular formula
C14H19NO2
CAS number
73950-85-5
IUPAC name
3-(1-methyl-4-piperidyl)-1H-indol-5-ol
State
State

At room temperature, O-Desmethyltramadol is in a solid state.

Melting point (Celsius)
92.50
Melting point (Kelvin)
365.70
Boiling point (Celsius)
288.30
Boiling point (Kelvin)
561.50
General information
Molecular weight
249.31g/mol
Molar mass
249.3410g/mol
Density
1.1980g/cm3
Appearence

O-Desmethyltramadol is typically found in a crystalline powder form. It is white to off-white in color.

Comment on solubility

Solubility of 3-(1-methyl-4-piperidyl)-1H-indol-5-ol

The compound 3-(1-methyl-4-piperidyl)-1H-indol-5-ol (C14H19NO2) exhibits interesting solubility characteristics that can be influenced by several factors. In general, the solubility of organic compounds like this one can be markedly affected by:

  • Polarity: The presence of both a piperidine group and hydroxyl (-OH) functional group in the structure may contribute to its ability to form hydrogen bonds with polar solvents such as water, enhancing its overall solubility.
  • Solvent Types: This compound will likely demonstrate greater solubility in organic solvents such as ethanol or methanol due to its hydrophobic indole ring system, which can interact favorably with non-polar environments.
  • pH Levels: Being an amine compound, the solubility may also change with varying pH levels, where protonation under acidic conditions can further increase solubility in aqueous solutions.

Overall, while empirical data on the precise solubility values for 3-(1-methyl-4-piperidyl)-1H-indol-5-ol may be limited, the combination of its functional groups suggests that:

  1. It has moderate solubility in polar solvents.
  2. It may exhibit improved solubility in less polar solvents due to the hydrophobic nature of its indole structure.

Understanding these solubility traits is crucial for applications in pharmaceutical development and formulation. As one might say, "Solubility is key to bioavailability."

Interesting facts

Interesting Facts about 3-(1-methyl-4-piperidyl)-1H-indol-5-ol

3-(1-methyl-4-piperidyl)-1H-indol-5-ol is a fascinating compound that has drawn attention in the realms of medicinal chemistry and pharmacology. Here are some intriguing insights about this compound:

  • Structure and Function: This compound features an indole ring system, which is a key structure in many biologically active molecules, illustrating its importance in drug development.
  • Piperidine Connection: The inclusion of a piperidine moiety enhances its affinity for specific biological targets, making it relevant in the design of pharmaceuticals.
  • Psychoactive Potential: Compounds akin to 3-(1-methyl-4-piperidyl)-1H-indol-5-ol have shown potential as neuroactive agents, indicating possible implications in treating conditions such as anxiety and depression.
  • Synthetic Routes: The synthesis of this compound usually involves multi-step reactions, showcasing the creativity and skills required in synthetic organic chemistry.
  • Research Implications: Ongoing studies aim to uncover its mechanism of action, leading to potential therapeutic applications.

Overall, 3-(1-methyl-4-piperidyl)-1H-indol-5-ol stands as a testament to how small structural variations in chemical compounds can significantly influence their biological activity and therapeutic potential. "The beauty of chemistry lies in its unpredictability and the logical patterns that emerge from the complexity," reflecting the dual nature of this compound in both its structure and its potential applications.

Synonyms
57477-39-1
BRL 54443
3-(1-methylpiperidin-4-yl)-1H-indol-5-ol
BRL-54443
BRL54443
1H-Indol-5-ol, 3-(1-methyl-4-piperidinyl)-
C14H18N2O
5-Hydroxy-3-(1-methylpiperidin-4-yl)-1H-indole
3-(1-METHYL-4-PIPERIDINYL)-1H-INDOL-5-OL
Q2DH1CHI0Y
5-Hydroxy-3-(1-Methylpiperidin-4-yl)indole
UNII-Q2DH1CHI0Y
NCGC00015134-01
Tocris-1129
Lopac-B-173
Biomol-NT_000107
Lopac0_000207
5-Hydroxy-3-(1-methylpiperidine-4-yl)-1H-indole
BPBio1_001401
GTPL3927
SCHEMBL3546728
CHEMBL1371156
CHEBI:92321
DTXSID40206089
WKNFADCGOAHBPG-UHFFFAOYSA-N
BCPP000316
HMS3267M18
HMS3412K13
HMS3651N17
HMS3676K13
HMS3742M07
HMS3884P18
BCP02618
EX-A2195
HB1664
MFCD01861184
s2852
AKOS022488633
BCP9000451
CCG-204302
CS-2025
GS-6123
SB19516
SDCCGSBI-0050195.P002
NCGC00015134-02
NCGC00015134-03
NCGC00015134-04
NCGC00015134-05
NCGC00015134-13
NCGC00025019-01
NCGC00025019-02
NCGC00025019-03
AC-32702
BM166950
HY-13221
DB-349958
SW220242-1
3-(1-Methylpiperidin-4-yl)-5-hydroxy-1H-indole
L000146
5-Hydroxy-3-(1-methylpiperidin-4-yl )-1H-indole
Q4836379
SR-01000075573-3
BRD-K17868609-001-02-7
BRD-K17868609-001-04-3
BRD-K17868609-001-05-0
HVU