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Nicotine (beta-nicotyrine)

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Identification
Molecular formula
C10H14N2O
CAS number
54-11-5
IUPAC name
3-(1-methylpyrrolidin-2-yl)-1H-indol-5-ol
State
State

At room temperature, nicotine is commonly present as a liquid. However, it can also be prepared in solid form under certain conditions.

Melting point (Celsius)
-79.00
Melting point (Kelvin)
194.00
Boiling point (Celsius)
247.00
Boiling point (Kelvin)
520.00
General information
Molecular weight
162.23g/mol
Molar mass
162.2300g/mol
Density
1.0100g/cm3
Appearence

The compound appears as a colorless to pale yellow liquid or solid, often turning brown upon exposure to air or light due to oxidation. It may have a faint pungent odor.

Comment on solubility

Solubility of 3-(1-methylpyrrolidin-2-yl)-1H-indol-5-ol

The solubility of 3-(1-methylpyrrolidin-2-yl)-1H-indol-5-ol can be influenced by various factors, including its molecular structure and the nature of the solvent used. Generally, the solubility of this compound can be summarized as follows:

  • Solvent Polarity: This compound is likely to exhibit different solubility profiles in polar versus non-polar solvents. For instance, it may dissolve better in polar organic solvents due to the presence of functional groups that can form hydrogen bonds.
  • pH Influence: The solubility may also vary with changes in pH, particularly if the compound has ionizable groups that could become charged, enhancing its solubility in aqueous solutions.
  • Temperature Dependence: Like many organic compounds, elevated temperatures can increase solubility by facilitating the dissolution process.

In summary, while specific solubility data for 3-(1-methylpyrrolidin-2-yl)-1H-indol-5-ol may not be readily available, understanding these factors can help predict its behavior in various environments. As with many compounds, experimenting with different solvents and conditions will be crucial for determining its solubility characteristics.

Interesting facts

Exploring 3-(1-methylpyrrolidin-2-yl)-1H-indol-5-ol

3-(1-methylpyrrolidin-2-yl)-1H-indol-5-ol is a fascinating compound that can be examined from various interdisciplinary angles, including medicinal chemistry, neuroscience, and materials science. Here are some interesting facts about this unique compound:

  • Structural Features: This compound incorporates an indole core, a structure frequently found in many biologically active natural products and pharmaceuticals. Its structural versatility allows it to facilitate various chemical interactions.
  • Biological Activity: The presence of the 1-methylpyrrolidin-2-yl group contributes to its potential biological significance, particularly as a neuropharmacological agent. Compounds similar to this have been studied for their potential effects on neurotransmitter systems.
  • Research and Applications: Scientists are particularly interested in exploring the compound's implications in areas such as:
    • Drug design and development
    • Neuroscience, specifically its role in mental health disorders
    • Material science, where such compounds may exhibit unique properties suitable for specific applications
  • Synthetic Routes: The synthesis of this compound can provide insight into advanced organic chemistry techniques, such as cyclization and functional group manipulation, making it a rich subject for study in synthetic methodologies.
  • Future Studies: Continued research on 3-(1-methylpyrrolidin-2-yl)-1H-indol-5-ol may reveal more about its potential therapeutic uses, particularly in treating neurological disorders or enhancing cognitive functions.

As new discoveries unfold, the academic and practical implications of this compound will surely inspire future innovations in various scientific fields. It serves as a prime example of how simple structural elements can lead to complex biological activity and diverse applications.

Synonyms
3-(1-Methyl-2-pyrrolidinyl)indol-5-ol
19134-34-0
BRN 0651558
INDOL-5-OL, 3-(1-METHYL-2-PYRROLIDINYL)-
3-(1-methylpyrrolidin-2-yl)-1H-indol-5-ol
DTXSID80940738