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3-(1-Methylpyrrolidin-3-yl)-1H-indole

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Identification
Molecular formula
C13H16N2
CAS number
1048973-47-2
IUPAC name
3-(1-methylpyrrolidin-3-yl)-1H-indole
State
State

At room temperature, 3-(1-Methylpyrrolidin-3-yl)-1H-indole is typically found in the solid state.

Melting point (Celsius)
78.00
Melting point (Kelvin)
351.15
Boiling point (Celsius)
370.00
Boiling point (Kelvin)
643.15
General information
Molecular weight
198.28g/mol
Molar mass
198.2780g/mol
Density
1.1500g/cm3
Appearence

3-(1-Methylpyrrolidin-3-yl)-1H-indole appears as a white to off-white crystalline solid. It may also be found as fine powder, depending on the purity and form of the compound.

Comment on solubility

Solubility of 3-(1-methylpyrrolidin-3-yl)-1H-indole

The solubility of 3-(1-methylpyrrolidin-3-yl)-1H-indole can vary significantly based on several factors, particularly its interactions with solvents. Here are some key points to consider:

  • Polar vs. Non-Polar Solvents: Generally, this compound exhibits greater solubility in non-polar solvents due to its organic structure.
  • Temperature Effects: Higher temperatures may enhance solubility as kinetic energy helps overcome intermolecular forces.
  • pH Influence: The solubility can also be affected by the pH of the solvent, as ionization can occur depending on the chemical nature of the compound.

Interestingly, it is often said that "like dissolves like" – meaning compounds tend to dissolve better in solvents that share similar polarity. Thus, when looking to dissolve 3-(1-methylpyrrolidin-3-yl)-1H-indole, consider using an organic solvent such as ethanol or dimethyl sulfoxide (DMSO) for optimal results.

In conclusion, while the solubility behavior of this compound may not be extensively documented, understanding its chemical structure and potential solvent interactions can provide valuable insights into its solubility profile.

Interesting facts

Interesting Facts about 3-(1-Methylpyrrolidin-3-yl)-1H-Indole

3-(1-Methylpyrrolidin-3-yl)-1H-indole represents a fascinating class of compounds known for their diverse applications in medicinal chemistry and pharmacology. Below are some engaging insights regarding this intriguing compound:

  • Structural Innovation: The presence of the indole moiety, combined with a pyrrolidine ring, provides a unique structural foundation that can influence biological activity significantly.
  • Biological Relevance: Indole derivatives are often found in nature and can act as crucial intermediates in the synthesis of various pharmaceuticals. The pyrrolidine part adds to its potential for creating novel therapeutic agents.
  • Potential Activity: Compounds containing indole structures are widely studied due to their potential roles as anticancer agents, antidepressants, and anti-inflammatory drugs. Their ability to interact with various biological targets makes them compelling subjects of research.
  • Research and Development: Many studies have shown that modifications to the indole backbone can lead to significant enhancements in efficacy and selectivity, thus making compounds like 3-(1-methylpyrrolidin-3-yl)-1H-indole crucial in drug design.
  • Pharmacophore Modeling: The study of the pharmacophore—features of the molecule necessary to ensure interaction with biological macromolecules—gains from the distinct arrangement of atoms in this compound, aiding in predicting interactions.
  • Versatile Synthesis: Researchers have developed various synthetic pathways to obtain compounds like this indole derivative, showcasing the versatility of organic synthesis techniques.

As a vivid example of the intersection between chemistry and biological sciences, 3-(1-methylpyrrolidin-3-yl)-1H-indole continues to be a promising area of research, ripe with possibilities for new discoveries and applications in drug development. Its unique structural characteristics facilitate a wide range of investigations into novel therapeutic avenues.

Synonyms
3671-00-9
INDOLE, 3-(1-METHYL-3-PYRROLIDINYL)-
3-(1-methylpyrrolidin-3-yl)-1H-indole
1H-Indole, 3-(1-methyl-3-pyrrolidinyl)-
MLS000736581
3-(1-Methyl-3-pyrrolidinyl)indole
NSC 43512
BRN 0912643
3-(1-Methyl-3-pyrrolidinyl)-1H-indole
NSC43512
SCHEMBL5253835
CHEMBL1340424
GIUCRWSFDBHBDT-UHFFFAOYSA-N
DTXSID601031949
NSC-43512
NCGC00246810-01
SMR000528205
Z1509146491