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Hydrocortisone

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Identification
Molecular formula
C21H30O5
CAS number
50-23-7
IUPAC name
3-[(10R,13R,14S)-14-hydroxy-10,13-dimethyl-3-oxo-7,8,9,11,12,15,16,17-octahydro-6H-cyclopenta[a]phenanthren-17-yl]-2H-furan-5-one
State
State
Hydrocortisone is typically a solid at room temperature. It is commonly encountered in its crystalline form in pharmaceutical formulations.
Melting point (Celsius)
215.00
Melting point (Kelvin)
488.15
Boiling point (Celsius)
590.00
Boiling point (Kelvin)
863.15
General information
Molecular weight
362.46g/mol
Molar mass
362.4600g/mol
Density
1.3100g/cm3
Appearence

Hydrocortisone is a white to practically white, crystalline powder that may occasionally appear as an amorphous powder. It has minimal solubility in water but is slightly soluble in alcohol and chloroform.

Comment on solubility

Solubility of 3-[(10R,13R,14S)-14-hydroxy-10,13-dimethyl-3-oxo-7,8,9,11,12,15,16,17-octahydro-6H-cyclopenta[a]phenanthren-17-yl]-2H-furan-5-one

The solubility of the chemical compound 3-[(10R,13R,14S)-14-hydroxy-10,13-dimethyl-3-oxo-7,8,9,11,12,15,16,17-octahydro-6H-cyclopenta[a]phenanthren-17-yl]-2H-furan-5-one (C21H30O5) is intriguing due to its complex structure. Understanding its solubility can help in various applications, such as pharmaceutical development. Key factors influencing solubility include:

  • Polarity: The compound contains multiple hydroxyl (-OH) groups which generally enhance solubility in polar solvents like water.
  • Functional Groups: The presence of a furan ring and several carbonyl groups can introduce both polar and non-polar character, affecting solubility in organic solvents.
  • Molecular Weight: With a substantial molecular weight, solubility may be limited in certain solvents compared to lower molecular weight compounds.
  • Hydrogen Bonding: Hydrogen bonding capabilities due to hydroxyl groups might increase interaction with solvent molecules, potentially improving solubility in suitable solvents.

In summary, the solubility of this compound is likely variable, potentially demonstrating higher solubility in organic solvents while being moderately soluble in water. It's essential to conduct specific experiments to determine the exact solubility parameters for practical applications.

Interesting facts

Interesting Facts about 3-[(10R,13R,14S)-14-hydroxy-10,13-dimethyl-3-oxo-7,8,9,11,12,15,16,17-octahydro-6H-cyclopenta[a]phenanthren-17-yl]-2H-furan-5-one

This compound, often referred to as a member of the furanone family, is notable for its complex structure and significant biological activity. Here are some key points:

  • Natural Origin: This furanone derivative has been isolated from various natural sources, showcasing the intricate ways in which nature can synthesize complex organic molecules.
  • Biological Activity: Compounds like this one have been studied for their potential therapeutic properties, particularly in the realms of cancer research and steroid biochemistry.
  • Chemical Diversity: The presence of a cyclopenta[a]phenanthrene moiety embedded in its structure exemplifies an interesting aspect of *steroid-like characteristics*, which can yield diverse biological effects.
  • Synthesis Challenges: The multi-step synthesis involving regioselective functionalization offers challenges in synthetic organic chemistry, emphasizing the need for innovative approaches in reaction conditions.
  • Structure-Activity Relationship (SAR): Understanding how structural variations influence biological activity can provide insights into drug design, highlighting the relevance of studying such complex compounds.

“The more we explore the vast chemistry of nature, the more we uncover the hidden treasures that can serve humanity.” This compound indeed represents that quest, illustrating the fusion of nature's ingenuity with the scientific pursuit of knowledge.

In conclusion, the unique attributes of this compound make it a subject of interest for ongoing research, particularly in medicinal chemistry and pharmacognosy. Its examination not only sheds light on its properties but also paves the way for future discoveries within the ever-evolving field of chemistry.

Synonyms
14-Hydroxy-3-oxocarda-1,4,20(22)-trienolide
DTXSID60928034