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Piperidyl benzodioxole

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Identification
Molecular formula
C19H20FNO3
CAS number
.508233-95-0
IUPAC name
3-(1,3-benzodioxol-5-yloxymethyl)-4-(4-fluorophenyl)piperidine
State
State

At room temperature, piperidyl benzodioxole is typically found in a solid state, appearing as crystalline structures. Its physical characteristics, such as solubility and optical properties, can depend on its precise stereochemistry and formulation.

Melting point (Celsius)
128.50
Melting point (Kelvin)
401.65
Boiling point (Celsius)
499.20
Boiling point (Kelvin)
772.35
General information
Molecular weight
327.37g/mol
Molar mass
327.3700g/mol
Density
1.2070g/cm3
Appearence

Piperidyl benzodioxole usually forms as a crystalline solid. The crystals may appear as off-white or slightly beige in color, depending on the purity of the compound.

Comment on solubility

Solubility of 3-(1,3-benzodioxol-5-yloxymethyl)-4-(4-fluorophenyl)piperidine

The solubility of the compound 3-(1,3-benzodioxol-5-yloxymethyl)-4-(4-fluorophenyl)piperidine, with the chemical formula C19H20FNO3, can be influenced by several factors due to its complex structure.

Key Factors Affecting Solubility:

  • Functional Groups: The presence of various functional groups, such as the benzodioxole moiety and the piperidine ring, may enhance solubility in polar solvents.
  • Hydrophobic vs. Hydrophilic Regions: The balance between hydrophobic and hydrophilic portions in the structure plays a crucial role in determining how well the compound dissolves in different solvents.
  • Polarity: As a molecule containing both aromatic rings and polar functional groups, its overall polarity is a significant determinant of solubility.

In general, this compound is expected to exhibit moderate solubility in organic solvents due to its hydrophobic characteristics, while its solubility in water may be limited compared to more polar compounds. It's essential to note that empirical data should be sought for precise solubility values and conditions.

Solubility Insights:

  • Solvents like ethanol and DMSO may dissolve this compound more effectively.
  • In contrast, water solubility could be lower due to the predominance of nonpolar character.

Ultimately, understanding the solubility properties of this compound is vital for its application in various chemical processes and formulations.

Interesting facts

Interesting Facts about 3-(1,3-benzodioxol-5-yloxymethyl)-4-(4-fluorophenyl)piperidine

The compound 3-(1,3-benzodioxol-5-yloxymethyl)-4-(4-fluorophenyl)piperidine is notable for its unique structure and potential applications in medicinal chemistry. Here are some intriguing aspects of this compound:

  • Origin of the Name: The nomenclature reflects its complex structure: the 1,3-benzodioxol moiety is a common framework in many psychoactive compounds, hinting at possible neurological interactions.
  • Fluorine Influence: The presence of a fluorophenyl group suggests enhanced metabolic stability and lipophilicity, often leading to improved bioavailability and efficacy in pharmaceutical applications. This feature is common in many successful drugs.
  • Potential Therapeutic Roles: Compounds with piperidine ring structures have been extensively studied for their role as analgesics and anti-anxiety medications. This compound, due to its unique substitutions, may influence the central nervous system, potentially leading to novel therapeutic agents.
  • Design and Synthesis: The synthesis of such compounds often involves complex multi-step processes, where chemists apply various organic reactions to incorporate specific functional groups. This opens up discussions about synthetic methodologies in advanced organic chemistry courses.
  • Research Opportunities: Due to its intriguing structure, there are numerous opportunities for further research. Exploring its interactions with neuronal receptors could yield valuable data for drug development.

In conclusion, the compound 3-(1,3-benzodioxol-5-yloxymethyl)-4-(4-fluorophenyl)piperidine embodies the intricate link between chemical structure and biological function, opening avenues for innovative pharmaceuticals. As one delves deeper into its properties, the potential for groundbreaking discoveries in the field of medicinal chemistry becomes apparent.

Synonyms
3-(1,3-benzodioxol-5-yloxymethyl)-4-(4-fluorophenyl)piperidine
3-[(2H-1,3-benzodioxol-5-yloxy)methyl]-4-(4-fluorophenyl)piperidine
72473-26-8
3-[(1,3-Benzodioxol-5-yloxy)methyl]-4-(4-fluorophenyl)piperidine
NCGC00182968-01
cis-(+)-Paroxetine Hydrochloride
Seroxat (Salt/Mix)
MLS006011860
SCHEMBL114238
CHEMBL169007
BDBM86422
CHEBI:94410
HMS3259B15
HMS3745E21
WFC17470
Paroxetine hydrochloride (Salt/Mix)
BBL010955
NSC_43815
STK802065
AKOS004119950
AKOS022061199
CCG-274934
NC00655
SMR001453706
CAS_61869-08-7
EN300-49845
L001179
BRD-A62326914-003-06-9
Q27166265
3-[(1,3-dioxaindan-5-yloxy)methyl]-4-(4-fluorophenyl)piperidine
4-(4-Fluorophenyl)-3-[(3,4methylenedioxyphenyl)oxymethyl]piperidine
3-((benzo[d][1,3]dioxol-5-yloxy)methyl)-4-(4-fluorophenyl)piperidine
4-(4-Fluorophenyl)-3-[(3,4-methylenedioxyphenyl)oxymethyl]piperidine
(-)-(3S,4R)-4-(p-Fluorophenyl)-3-[((3,4-methylenedioxy)phenoxy]methyl]piperidine
3-[(1,3-Benzodioxol-5-yloxy)methyl]-4-(4-fluorophenyl)piperidine, (-)-(3S,4R)-
63952-24-9