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Nicotine

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Identification
Molecular formula
C10H14N2
CAS number
54-11-5
IUPAC name
3-(1,3-dimethylpyrrolidin-2-yl)-1H-indole
State
State

Nicotine is a liquid at room temperature.

Melting point (Celsius)
-79.00
Melting point (Kelvin)
194.15
Boiling point (Celsius)
247.00
Boiling point (Kelvin)
520.15
General information
Molecular weight
162.24g/mol
Molar mass
162.2380g/mol
Density
1.0100g/cm3
Appearence

Nicotine is a colorless to pale yellow, oily liquid. It has a characteristic acrid, unpleasant odor and a burning taste. When exposed to air, nicotine takes on a reddish-brown color due to oxidation.

Comment on solubility

Solubility of 3-(1,3-dimethylpyrrolidin-2-yl)-1H-indole

The solubility of 3-(1,3-dimethylpyrrolidin-2-yl)-1H-indole, a compound with intriguing structural features, can be influenced by various factors including temperature, pH, and the presence of solvents. Here are some key points regarding its solubility:

  • Organic Solvents: This compound is generally more soluble in polar aprotic solvents such as DMSO (dimethyl sulfoxide) and DMF (dimethylformamide), which enhance its dissolution.
  • Water Solubility: Due to its hydrophobic indole core, the solubility of 3-(1,3-dimethylpyrrolidin-2-yl)-1H-indole in water is relatively low, making it less favorable for aqueous formulations.
  • Temperature Effects: As with many organic compounds, increasing the temperature may improve solubility, leading to greater molecular movement and interaction.

It is essential to consider these attributes when utilizing 3-(1,3-dimethylpyrrolidin-2-yl)-1H-indole in research and applications, especially in contexts where solubility plays a crucial role in its effectiveness.

In summary, while this compound exhibits a preference for organic solvents, its limited aqueous solubility necessitates careful solvent selection for appropriate use in various chemical and biological assays.

Interesting facts

Interesting Facts about 3-(1,3-dimethylpyrrolidin-2-yl)-1H-indole

This fascinating compound belongs to a class of organic compounds known for their diverse applications in medicinal chemistry. 3-(1,3-dimethylpyrrolidin-2-yl)-1H-indole contains an indole moiety, a structure that is widely recognized for its biological significance.

Key Attributes

  • Indole Framework: The indole structure is found in many naturally occurring compounds and is known for its presence in various alkaloids, which are biologically active compounds.
  • Pyrrolidine Substituent: The addition of the dimethylpyrrolidine group suggests potential applications in enhancing binding affinity in biological systems, making it a target for drug discovery.
  • Diverse Biological Activities: Compounds containing indole and pyrrolidine have been shown to possess a range of activities, including anti-inflammatory, anti-cancer, and neuroprotective effects.

In the realm of research, compounds like 3-(1,3-dimethylpyrrolidin-2-yl)-1H-indole are often investigated for their interactions with neurotransmitter systems. As a result, they may hold potential for treating conditions such as:

  • Depression
  • Anxiety disorders
  • Cognitive decline

As you delve deeper into the exploration of this compound, remember that the intricate balance between its structure and functionality often dictates its potential in pharmaceutical applications. The ongoing research in this area not only paves the way for new therapeutic agents but also underlines the importance of chemical diversity in drug design. In the words of a renowned chemist, “Understanding the *structure-activity relationship* is key to unlocking the mysteries of medicinal chemistry.”

Synonyms
3-(1,3-dimethylpyrrolidin-2-yl)-1H-indole
801175-13-3
3-(1,3-Dimethyl-2-pyrrolidinyl)-1H-indole
DB-276828
INDOLE, 3-(1,3-DIMETHYL-2-PYRROLIDINYL)-