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VX-950

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Identification
Molecular formula
C25H31N3O
CAS number
198474-91-8
IUPAC name
3-(1,5,5-trimethylpyrrolidin-2-yl)-1H-indole
State
State

At room temperature, 3-(1,5,5-trimethylpyrrolidin-2-yl)-1H-indole is typically in a solid state. It has a crystalline structure, which is consistent with many indole derivatives that are used in various applications.

Melting point (Celsius)
250.30
Melting point (Kelvin)
523.50
Boiling point (Celsius)
447.50
Boiling point (Kelvin)
720.70
General information
Molecular weight
366.48g/mol
Molar mass
366.4750g/mol
Density
1.2780g/cm3
Appearence

3-(1,5,5-trimethylpyrrolidin-2-yl)-1H-indole typically appears as a crystalline solid that is pale yellow to off-white in color. The specific crystalline structure can vary based on the conditions of crystallization and the presence of any impurities or solvents in the sample.

Comment on solubility

Solubility of 3-(1,5,5-trimethylpyrrolidin-2-yl)-1H-indole

The solubility of 3-(1,5,5-trimethylpyrrolidin-2-yl)-1H-indole can be quite intriguing due to its unique chemical structure. Solubility is influenced by a variety of factors including:

  • Polarity: The presence of both hydrophobic and hydrophilic regions can affect how well the compound dissolves in different solvents.
  • Hydrogen Bonding: Functional groups capable of forming hydrogen bonds can enhance solubility in polar solvents.
  • Molecular Interactions: Van der Waals forces and dipole interactions can also play a significant role in solubility.

In general, indole derivatives tend to exhibit varying degrees of solubility depending on their substituents. As such, 3-(1,5,5-trimethylpyrrolidin-2-yl)-1H-indole may show:

  • Good solubility in organic solvents due to its hydrophobic indole structure.
  • Limited solubility in water because of the bulky trimethylpyrrolidine group, which can hinder hydrogen bonding with water molecules.

In conclusion, the solubility of this compound is a balance of its structural characteristics, which influence its behavior in different solvents. As one expert noted, "Understanding solubility is key to predicting the behavior of chemical compounds in various environments."

Interesting facts

Interesting Facts about 3-(1,5,5-trimethylpyrrolidin-2-yl)-1H-indole

The compound 3-(1,5,5-trimethylpyrrolidin-2-yl)-1H-indole holds significant interest within various scientific disciplines, especially in medicinal chemistry and drug development. Here are some intriguing aspects of this compound:

  • Molecular Framework: This compound features an indole moiety, which is a well-known structure in many biologically active molecules. Indole derivatives are often investigated for their potential as pharmaceuticals.
  • Biological Activity: Compounds containing indole structures frequently exhibit a range of biological activities, including anti-inflammatory, analgesic, and even anticancer properties, making it a hot topic in therapeutic research.
  • Pyrrolidine Component: The presence of a pyrrolidine ring, particularly with tri-substitution, suggests possible interactions with biological targets, enhancing the compound's efficacy. Pyrrolidines are also noted for their role in CNS modulation.
  • Structure-Activity Relationship (SAR): Understanding how the structure impacts biological effectiveness is crucial. The variations in substitution patterns can lead to significant changes in the activity profile, which is essential for drug optimization.
  • Potential Applications: Given its unique structure, this compound may provide leads in the development of novel therapeutic agents for conditions such as depression, anxiety, or neurodegenerative disorders.

As noted by researchers, "The integration of distinct pharmacophores creates opportunities for innovative therapeutic strategies." The exploration of compounds like 3-(1,5,5-trimethylpyrrolidin-2-yl)-1H-indole exemplifies the exciting advancements in medicinal chemistry, aiming for a better understanding and treatment of various diseases.

Synonyms
3-(1,5,5-trimethylpyrrolidin-2-yl)-1H-indole
19137-80-5
3-(1,5,5-Trimethyl-2-pyrrolidinyl)-1H-indole
BRN 0519099
3-(1,5,5-Trimethyl-2-pyrrolidinyl)indole
INDOLE, 3-(1,5,5-TRIMETHYL-2-PYRROLIDINYL)-
DTXSID10940746