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Histidine

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Identification
Molecular formula
C3H5N3O2
CAS number
71-00-1
IUPAC name
3-(1H-imidazol-5-yl)prop-2-enoic acid
State
State

Histidine is typically a solid at room temperature. It is usually encountered as a crystalline powder or in the form of granules.

Melting point (Celsius)
287.00
Melting point (Kelvin)
560.15
Boiling point (Celsius)
331.95
Boiling point (Kelvin)
605.10
General information
Molecular weight
155.16g/mol
Molar mass
155.1560g/mol
Density
1.5400g/cm3
Appearence

Histidine appears as white crystals or a crystalline powder. It is less commonly found in other forms, such as a monohydrate. The powder is highly soluble in water.

Comment on solubility

Solubility of 3-(1H-imidazol-5-yl)prop-2-enoic acid (C3H5N3O2)

The solubility of 3-(1H-imidazol-5-yl)prop-2-enoic acid is an intriguing aspect of its chemical behavior. This compound, characterized by its unique imidazole group, displays various solubility properties that can be influenced by several factors.

Factors Affecting Solubility:

  • Polarity: The presence of both carboxylic acid and imidazole functional groups suggests that this compound is polar, which typically enhances solubility in polar solvents.
  • pH Dependence: The solubility may vary significantly with changes in pH, particularly due to the ionizable carboxylic acid group. In acidic conditions, it may remain un-ionized, whereas in basic environments, it can dissociate, increasing its solubility.
  • Temperature: Like many organic compounds, temperature can also play a crucial role. Increased temperature often leads to higher solubility in many solvents.

In general, compounds with similar structures tend to exhibit good solubility in aqueous solutions due to the hydrophilic nature of their functional groups. As stated, *“water solubility often increases with an increase in polarity.”* Thus, one could expect that 3-(1H-imidazol-5-yl)prop-2-enoic acid would likely dissolve well in polar solvents such as water.

Overall, the solubility characteristics of 3-(1H-imidazol-5-yl)prop-2-enoic acid illustrate the complex interactions between its chemical structure and the solvent environment.

Interesting facts

Exploring 3-(1H-imidazol-5-yl)prop-2-enoic acid

3-(1H-imidazol-5-yl)prop-2-enoic acid, often referred to in the scientific community as an important derivative that contains both imidazole and an acrylate group. This fascinating compound presents a compelling area of study due to its unique structural and chemical features. Here are some intriguing aspects:

  • Biodiversity: Compounds like this one are frequently highlighted in biological systems, particularly for their roles as intermediates in the synthesis of various biomolecules.
  • Pharmaceutical Applications: The imidazole ring in this compound is a well-known pharmacophore. Many drugs incorporate this structure, making compounds like 3-(1H-imidazol-5-yl)prop-2-enoic acid vital in medicinal chemistry.
  • Research Potential: With continual advances in chemical synthesis and reactivity studies, this compound could serve as a precursor to novel materials or therapeutic agents.
  • Chemical Reactivity: The presence of an unsaturated double bond within the prop-2-enoic acid moiety offers interesting avenues for chemical reactions, such as addition reactions with nucleophiles.

The versatility and chemical diversity presented by 3-(1H-imidazol-5-yl)prop-2-enoic acid makes it a compound of substantial interest in both theoretical and applied chemistry. As one researcher put it, “The true power of organic compounds lies in their endless potential for innovation and utility.” This compound exemplifies just that!


Synonyms
2-Propenoic acid, 3-(1H-imidazol-4-yl)-
(E)-3-(1H-Imidazol-5-yl)-2-propenoic acid
(Z)-Urocanic acid;cis-UCA
CCRIS 3414
DTXSID50859181
e-urocanic acid
EINECS 203-258-4
BRN 0081405
4-25-00-00786 (Beilstein Handbook Reference)
imidazole-5-acrylic acid
NCIOpen2_003815
(E)-3-(5-Imidazolyl)acrylic Acid
AKOS024285611
NCI60_021801
SY234874
DB-040584
NS00123243