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Indoprofen

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Identification
Molecular formula
C22H22N2O4S
CAS number
31842-01-0
IUPAC name
3-(1H-indol-3-yl)-2-[[4-(4-phenyl-1-piperidyl)phenyl]sulfonylamino]propanoic acid
State
State
Indoprofen is typically a solid at room temperature and ambient conditions. It is often used in its solid form in pharmaceutical applications.
Melting point (Celsius)
153.00
Melting point (Kelvin)
426.15
Boiling point (Celsius)
735.20
Boiling point (Kelvin)
1 008.40
General information
Molecular weight
411.50g/mol
Molar mass
411.4960g/mol
Density
1.3200g/cm3
Appearence
Indoprofen is typically presented in solid form as a white or off-white crystalline powder. It is a nonsteroidal anti-inflammatory drug (NSAID) and may appear in pharmaceutical preparations.
Comment on solubility

Solubility of 3-(1H-indol-3-yl)-2-[[4-(4-phenyl-1-piperidyl)phenyl]sulfonylamino]propanoic acid

The solubility of 3-(1H-indol-3-yl)-2-[[4-(4-phenyl-1-piperidyl)phenyl]sulfonylamino]propanoic acid (C22H22N2O4S) presents notable characteristics relevant to its structure and chemical interactions:

  • Polar Functional Groups: The presence of sulfonyl and carboxylic acid groups in its structure typically enhances solubility in polar solvents such as water. These functional groups can form hydrogen bonds with solvent molecules.
  • Hydrophobic Regions: The indole and phenyl components contribute to hydrophobicity, which may limit solubility in aqueous environments, potentially leading to low solubility in pure water.
  • Solvent Effects: Solubility may vary significantly with different solvents; it may exhibit better solubility in organic solvents like ethanol or dimethyl sulfoxide (DMSO) compared to water due to reduced hydrogen bonding interactions.
  • pH Influence: The carboxylic acid group can dissociate at higher pH values, resulting in increased solubility in basic solutions compared to neutral or acidic conditions.

To summarize, the solubility of this compound is influenced by a balance between its hydrophilic and hydrophobic characteristics. Understanding these properties is crucial for applications in pharmaceuticals and biochemistry, allowing researchers to optimize formulations and dosage forms effectively.

Interesting facts

Interesting Facts About 3-(1H-indol-3-yl)-2-[[4-(4-phenyl-1-piperidyl)phenyl]sulfonylamino]propanoic Acid

3-(1H-indol-3-yl)-2-[[4-(4-phenyl-1-piperidyl)phenyl]sulfonylamino]propanoic acid is a fascinating compound that falls under the category of biologically active molecules. Here are some intriguing aspects of this compound that highlight its significance in the field of chemistry:

  • Complex Structure: The molecule includes both an indole and a piperidine structure, which are known for their roles in a variety of biological activities. The indole moiety is a common scaffold in many pharmaceuticals, underscoring the compound's potential therapeutic applications.
  • Biological Activity: This compound has garnered interest due to its potential as a modulator in biological systems. Compounds with similar structures have been investigated for their roles in antidepressant and antipsychotic properties.
  • Design and Synthesis: The synthesis of this compound involves sophisticated organic chemistry techniques, allowing scientists to manipulate its structure to enhance bioactivity. As students often find, "the magic in chemistry lies in the ability to create and modify molecules."
  • Targets: Researchers are exploring its interactions with various biological targets, particularly in the field of neuropharmacology. The sulfonamide group present in the compound often contributes to the pharmacophoric characteristics that are desirable in drug development.
  • Potential Applications: Given its structural complexity and the presence of moieties known for their therapeutic effects, this compound may hold promise for future pharmacological applications, particularly in designing new drugs aimed at treating mood disorders.

In summary, the compound 3-(1H-indol-3-yl)-2-[[4-(4-phenyl-1-piperidyl)phenyl]sulfonylamino]propanoic acid illustrates the profound connection between chemistry and medicine. Its intricate structure and potential biological impact make it a compelling subject for researchers and chemistry enthusiasts alike.

Synonyms
SCHEMBL4312530
PD042560