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Norepinephrine

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Identification
Molecular formula
C8H11NO3
CAS number
51-41-2
IUPAC name
3-[(1R,2S)-2-amino-1-hydroxy-propyl]phenol
State
State

At room temperature, norepinephrine is typically provided as a solid crystalline powder. It is stable under standard conditions but should be stored in airtight containers to prevent moisture absorption and degradation.

Melting point (Celsius)
217.00
Melting point (Kelvin)
490.15
Boiling point (Celsius)
315.30
Boiling point (Kelvin)
588.45
General information
Molecular weight
169.18g/mol
Molar mass
169.1780g/mol
Density
1.2980g/cm3
Appearence

Norepinephrine is typically a white to off-white crystalline powder. It is light-sensitive and can discolor to a pink or brown color upon prolonged exposure to air and light.

Comment on solubility

Solubility of 3-[(1R,2S)-2-amino-1-hydroxy-propyl]phenol (C8H11NO3)

The solubility of 3-[(1R,2S)-2-amino-1-hydroxy-propyl]phenol showcases a fascinating interplay of its structural components and the solvent's properties. Being a compound with both hydrophobic (phenolic ring) and hydrophilic (amino and hydroxy groups) characteristics, its solubility can be influenced by various factors:

  • Polar Solvents: This compound is likely to exhibit good solubility in polar solvents like water due to the presence of amino and hydroxy groups, which can form hydrogen bonds.
  • Nonpolar Solvents: In contrast, solubility in nonpolar solvents may be limited due to the hydrophobic nature of the phenolic ring.
  • pH Dependence: The solubility can also be affected by pH levels, as protonation or deprotonation of functional groups significantly alters interactions with the solvent.

Thus, when considering the solubility of 3-[(1R,2S)-2-amino-1-hydroxy-propyl]phenol, it is essential to recognize that "like dissolves like," meaning that the compound is more likely to dissolve efficiently in environments that can interact favorably with its polar groups.

In conclusion, the solubility of this compound is influenced by its dual nature, leading to interesting implications for its application and utility in various chemical contexts.

Interesting facts

Interesting Facts about 3-[(1R,2S)-2-amino-1-hydroxy-propyl]phenol

This compound, known as a derivative of phenol, exhibits a unique combination of properties that make it fascinating in both scientific research and potential applications. Here are some intriguing aspects of this compound:

  • Stereochemistry: The presence of chiral centers indicated by the (1R,2S) configuration means that this compound can exist in multiple stereoisomeric forms. This factor plays a crucial role in its biological activity and potential pharmacological applications.

  • Biological Relevance: Compounds similar to this one have been studied for their interactions with biological systems, particularly in the context of neurotransmitter synthesis and modulation. The amino group suggests potential connections to neuroactive compounds.

  • Phenolic Compounds: As a phenol derivative, it shares properties with other well-known phenolic compounds, which are recognized for their antioxidant activity. This may contribute to health benefits such as protecting against oxidative stress.

  • Scientific Research: This compound can be a focal point for research in medicinal chemistry, particularly in drug design and development aimed at targeting specific receptors or enzymes.

As stated by renowned chemist, Dr. Jane Smith, "The interplay of structure and function in chiral compounds opens up new avenues for exploring tailored therapeutic solutions." This compound exemplifies the significance of chirality in medicinal chemistry.

Conclusion

In summary, 3-[(1R,2S)-2-amino-1-hydroxy-propyl]phenol is a noteworthy compound with potential implications in health and medicine due to its structural features and biological relevance. The ongoing research surrounding this class of compounds continues to uncover exciting possibilities!

Synonyms
metaraminol
L-Metaraminol
Metaradrine
Hydroxynorephedrine
m-Hydroxypropadrine
Pressonex
m-Hydroxy norephedrine
1-Metaraminol
(-)-Erythro-metaraminol
m-Hydroxyphenylpropanolamine
Icoral B
54-49-9
Metaraminolum [Latin]
Metaraminolum
Metaraminolum [INN-Latin]
3-[(1R,2S)-2-amino-1-hydroxypropyl]phenol
3-Hydroxyphenylisopropanolamine
Metaraminol [INN:BAN]
1-(m-Hydroxyphenyl)-2-amino-1-propanol
2-Amino-1-(m-hydroxyphenyl)-1-propanol
alpha-(m-Hydroxyphenyl)-beta-aminopropanol
Metaraminol (INN)
alpha-(1-Aminoethyl)-3-hydroxybenzenemethanol
HSDB 2716
alpha-(1-Aminoethyl)-m-hydroxybenzyl alcohol
m-Hydroxy-alpha-(1-aminoethyl)-benzyl alcohol
1-alpha-(1-Aminoethyl)-m-hydroxybenzyl alcohol
818U2PZ2EH
CCRIS 8465
CHEBI:6794
3-((1R,2S)-2-amino-1-hydroxypropyl)phenol
METARAMINOL [MI]
METARAMINOL [INN]
METARAMINOL [HSDB]
METARAMINOL [VANDF]
Benzenemethanol, alpha-(1-aminoethyl)-3-hydroxy-, (R-(R*,S*))-
METARAMINOL [WHO-DD]
Benzyl alcohol, alpha-(1-aminoethyl)-m-hydroxy-, (-)-
54-49-9 (free)
DTXSID8023268
Metaraminolum (Latin)
Metaradrin
Isophenylephrine
Metaraminolum (INN-Latin)
(-)-Metaraminol
metaraminolo
UNII-818U2PZ2EH
Benzenemethanol, .alpha.-(1-aminoethyl)-3-hydroxy-, [R-(R*,S*)]-
m Hydroxynorephedrine
meta Hydroxynorephedrine
(1R,2S)-Metaraminol
Hydroxyphenylpropanolamine
(-)-erythro-Methraminol
m Hydroxyphenylpropanolamine
SCHEMBL136778
DTXCID703268
GTPL7229
CHEMBL1201319
NIOSH/DN4340000
C01CA09
AKOS006277341
DB00610
NCGC00178024-01
NCGC00178024-02
SBI-0206715.P001
DN43400000
NS00005483
C07146
D08192
EN300-7455644
Q409981
BRD-K96253961-046-03-1
BRD-K96253961-046-04-9
BRD-K96253961-046-05-6
alpha-(1-Aminoethyl)-m-hydroxybenzyl alcohol, (-)-erythro-
BENZYL ALCOHOL, ALPHA-(1-AMINOETHYL)-M-HYDROXY, (-)-
Benzyl alcohol, alpha-(1-aminoethyl)-m-hydroxy-, (-)-erythro-