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Ramipril

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Identification
Molecular formula
C23H32N2O5
CAS number
87333-19-5
IUPAC name
3-[2-[(1-ethoxycarbonyl-3-phenyl-propyl)amino]propanoyl]-1-methyl-2-oxo-imidazolidine-4-carboxylic acid
State
State

Ramipril is typically in a solid state at room temperature.

Melting point (Celsius)
109.00
Melting point (Kelvin)
382.15
Boiling point (Celsius)
120.50
Boiling point (Kelvin)
393.65
General information
Molecular weight
416.50g/mol
Molar mass
416.4960g/mol
Density
1.0695g/cm3
Appearence

Ramipril appears as a white to almost white crystalline powder. It is a lipophilic drug, which implies that it is more soluble in organic solvents as compared to water.

Comment on solubility

Solubility of 3-[2-[(1-ethoxycarbonyl-3-phenyl-propyl)amino]propanoyl]-1-methyl-2-oxo-imidazolidine-4-carboxylic acid

The solubility of this complex compound, C23H32N2O5, can vary significantly based on several factors. It is important to consider the molecular structure and functional groups present when evaluating its solubility characteristics:

  • Polarity: The presence of polar functional groups, like the carboxylic acid (-COOH) and the ethoxy compound groups, may enhance solubility in polar solvents such as water.
  • Hydrophobic regions: The phenyl and ethyl portions of the compound introduce hydrophobic characteristics, which can reduce solubility in water but may improve solubility in organic solvents.
  • pH influence: Solubility may be affected by pH levels. Carboxylic acids typically ionize in basic conditions, potentially increasing water solubility.

It can be summarized that:

  1. High solubility in polar solvents due to the presence of polar groups.
  2. Reduced solubility in non-polar solvents owing to the hydrophobic portions.
  3. Varied solubility depending on environmental pH which might enhance or diminish solvation properties.

In conclusion, the overall solubility profile of 3-[2-[(1-ethoxycarbonyl-3-phenyl-propyl)amino]propanoyl]-1-methyl-2-oxo-imidazolidine-4-carboxylic acid can be described as moderately complex, with a necessity to evaluate specific solvation conditions to predict behavior accurately.

Interesting facts

Interesting Facts about 3-[2-[(1-ethoxycarbonyl-3-phenyl-propyl)amino]propanoyl]-1-methyl-2-oxo-imidazolidine-4-carboxylic acid

This complex compound belongs to the class of imidazolidine derivatives, which have garnered interest in medicinal chemistry due to their diverse biological activities. Here are some fascinating points to consider:

  • Structure and Function: The intricate structure of this compound features an imidazolidine ring, which is pivotal in many natural products and pharmaceuticals. Its unique arrangement allows for interactions with various biological targets.
  • Medicinal Potential: Compounds similar to this one have shown promise in research for their potential role as antimicrobial agents, as well as possessing anti-inflammatory properties. This makes them intriguing candidates for further study in drug development.
  • Amine Groups: The presence of amino groups in this compound enhances its potential reactivity, allowing it to participate in vital biochemical processes, such as enzymatic activity or receptor binding.
  • Ethoxycarbonyl Functionality: The ethoxycarbonyl moiety is an essential aspect of the compound that may contribute to its ability to cross cell membranes and exert therapeutic effects.
  • Research Applications: Due to its structural complexity, this compound could serve as a model for investigating the structure-activity relationship (SAR) in similar imidazolidine compounds, facilitating the design of more efficient drugs.

This compound exemplifies the fascinating intersection of organic chemistry and pharmacology, showcasing how even the most complex structures can lead to significant advancements in medicinal science. As scientists delve deeper into the characteristics and applications of such compounds, they unlock potential therapies for a wide array of diseases.

Synonyms
SCHEMBL683273
DTXSID80861111
HMS3651K12
BCP12557
NCGC00389199-01
DB-057129
120294-10-2
3-[N-(1-Ethoxy-1-oxo-4-phenylbutan-2-yl)alanyl]-1-methyl-2-oxoimidazolidine-4-carboxylic acid