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Iodixanol

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Identification
Molecular formula
C35H44I6N6O15
CAS number
92339-11-2
IUPAC name
3-[[2-[2-[2-[2-(3-carboxy-2,4,6-triiodo-anilino)-2-oxo-ethoxy]ethoxy]ethoxy]acetyl]amino]-2,4,6-triiodo-benzoic acid
State
State

At room temperature, Iodixanol is typically in a solid state when in its pure form. However, for practical use, especially in clinical settings, it is prepared as an aqueous solution where it functions optimally as a contrast medium.

Melting point (Celsius)
163.00
Melting point (Kelvin)
436.15
Boiling point (Celsius)
250.00
Boiling point (Kelvin)
523.15
General information
Molecular weight
1550.20g/mol
Molar mass
1 550.2000g/mol
Density
2.0000g/cm3
Appearence

Iodixanol typically appears as a white to off-white crystalline powder. It is typically used in solution form as a contrast agent in medical imaging, such as X-rays and CT scans. In its powdered form, it must be handled with care in a controlled environment to prevent any reactions or changes in its structure.

Comment on solubility

Solubility of 3-[[2-[2-[2-[2-(3-carboxy-2,4,6-triiodo-anilino)-2-oxo-ethoxy]ethoxy]ethoxy]acetyl]amino]-2,4,6-triiodo-benzoic acid

The solubility characteristics of complex compounds such as 3-[[2-[2-[2-[2-(3-carboxy-2,4,6-triiodo-anilino)-2-oxo-ethoxy]ethoxy]ethoxy]acetyl]amino]-2,4,6-triiodo-benzoic acid (C35H44I6N6O15) are critical to their application in various chemical and medicinal fields. Here are some essential points regarding its solubility:

  • Polar Functional Groups: The presence of multiple polar functional groups, including carboxylic acid and ether components, generally enhances the solubility of the compound in polar solvents like water.
  • Iodine Atoms: The high degree of iodination (six iodine atoms) may lead to reduced solubility in non-polar solvents due to increased molecular size and density.
  • Complex Formation: Such complex structures may engage in solvation effects, where surrounding solvent molecules stabilize the compound in solution.
  • pH Dependence: The solubility of the carboxylic acid group may vary significantly with pH, being more soluble in basic conditions due to deprotonation.
  • Temperature Effects: Increased temperature can also enhance solubility by facilitating the breaking of intermolecular forces.

In summary, the solubility of this compound is multifaceted, influenced by both its chemical structure and the external conditions of the solvent. As stated in molecular chemistry, "The more diverse the structure, the more intricate the solubility behavior." Understanding these nuances is vital for optimizing the practical use of such compounds.

Interesting facts

Interesting Facts about 3-[[2-[2-[2-[2-(3-carboxy-2,4,6-triiodo-anilino)-2-oxo-ethoxy]ethoxy]ethoxy]acetyl]amino]-2,4,6-triiodo-benzoic acid

This fascinating compound, often associated with imaging applications in medicine, exhibits a remarkable arrangement of atoms that makes it particularly useful in the field of radiology. Here are some noteworthy points about it:

  • Radiocontrast Agent: The presence of multiple iodine atoms in its structure lends this compound excellent X-ray-absorbing properties. This makes it a prime candidate for use as a radiocontrast agent in various imaging modalities.
  • Complex Structure: With a diverse chain of ethoxy groups and a carboxylic acid functionality, the compound showcases a complex architecture that contributes to its biological activity and efficacy as a contrast agent.
  • Applications in Medical Imaging: This compound plays a vital role in enhancing the visibility of vascular structures during imaging, aiding in accurate diagnosis and treatment planning.
  • Biocompatibility: The biocompatible nature of the compound is essential, ensuring minimal adverse reactions within the human body during procedures.
  • Research Potential: Ongoing studies continue to explore the efficacy of this compound in various diagnostic procedures, increasing its importance in both research and clinical settings.

In summary, the unique features and applications of 3-[[2-[2-[2-[2-(3-carboxy-2,4,6-triiodo-anilino)-2-oxo-ethoxy]ethoxy]ethoxy]acetyl]amino]-2,4,6-triiodo-benzoic acid underline its significant role in enhancing medical imaging, making it an exciting area of study for chemists and medical professionals alike.

Synonyms
iotroxic acid
Biliscopin
51022-74-3
Acido iotroxico
Acide iotroxique
Acidum iotroxicum
Iotroxinsaeure
Iotroxinsaeure [German]
Acido iotroxico [INN-Spanish]
SH 213AB
Acide iotroxique [INN-French]
Acidum iotroxicum [INN-Latin]
3-[[2-[2-[2-[2-(3-carboxy-2,4,6-triiodoanilino)-2-oxoethoxy]ethoxy]ethoxy]acetyl]amino]-2,4,6-triiodobenzoic acid
SH 213 AB
EINECS 256-917-3
Iotroxic acid [USAN:INN:BAN:JAN]
BRN 2800081
84C5PTP9X6
SH-213AB
DTXSID3048782
SH-213 AB
IOTROXIC ACID [INN]
IOTROXIC ACID [JAN]
3,3'-(3,6,9-Trioxaundecanedioyldiamino)bis(2,4,6-triiodobenzoic acid)
IOTROXIC ACID [USAN]
3,3'-(Oxybis(ethyleneoxymethylenecarbonylimino))bis(2,4,6-triiodobenzoic acid)
IOTROXIC ACID [MART.]
IOTROXIC ACID [WHO-DD]
IOTROXIC ACID [WHO-IP]
DTXCID9028708
3,3'-(2,2'-Oxydiethylenedioxybisacetamido)bis(2,4,6-triiodobenzoic acid)
Benzoic acid, 3,3'-(oxybis(2,1-ethanediyloxy(1-oxo-2,1-ethanediyl)imino))bis(2,4,6, triiodo-
Benzoic acid, 3,3'-(oxybis(2,1-ethanediyloxy(1-oxo-2,1-ethanediyl)imino))bis(2,4,6-triiodo-
ACIDUM IOTROXICUM [WHO-IP LATIN]
NCGC00183025-01
3,3'-(Oxybis(2,1-ethanediyloxy(1-oxo-2,1-ethanediyl)imino)bis(2,4,6-triiodobenzoic acid)
IOTROXIC ACID (MART.)
Acide iotroxique (INN-French)
Acido iotroxico (INN-Spanish)
Acidum iotroxicum (INN-Latin)
iotroxicacid
UNII-84C5PTP9X6
io-troxic acid
3-((2-(2-(2-(2-(3-carboxy-2,4,6-triiodoanilino)-2-oxoethoxy)ethoxy)ethoxy)acetyl)amino)-2,4,6-triiodobenzoic acid
SCHEMBL38038
CHEMBL1651905
CHEBI:31716
V08AC02
JXMIBUGMYLQZGO-UHFFFAOYSA-N
Iotroxic acid (JP17/USAN/INN)
Tox21_113258
DB08945
DA-74508
CAS-51022-74-3
HY-148155
CS-0613905
NS00014342
D01388
Q3183847
3,3'-(3,6,9-Trioxaundecanedioyl)diiminobis(2,4,6-triiodobenzoic acid)
256-917-3
3,3'-(oxybis(2,1-ethanediyloxy(1-oxo-2,1-ethanediyl)imino)bis(2,4,6-tri iodobenzoic acid))