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Iodixanol

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Identification
Molecular formula
C35H44I6N6O15
CAS number
92339-11-2
IUPAC name
3-[[2-[2-(3-carboxy-2,4,6-triiodo-anilino)-2-oxo-ethoxy]acetyl]amino]-2,4,6-triiodo-benzoic acid
State
State

At room temperature, iodixanol is a solid, typically provided as a powder for use in preparing solutions for intravenous injection in imaging studies.

Melting point (Celsius)
165.00
Melting point (Kelvin)
438.15
Boiling point (Celsius)
0.00
Boiling point (Kelvin)
0.00
General information
Molecular weight
1550.34g/mol
Molar mass
1 550.3440g/mol
Density
1.3200g/cm3
Appearence

Iodixanol appears as a white to off-white crystalline powder. It is soluble in water and forms a clear, colorless to pale yellow solution when dissolved. It is an iodinated contrast medium used primarily in medical imaging.

Comment on solubility

Solubility of 3-[[2-[2-(3-carboxy-2,4,6-triiodo-anilino)-2-oxo-ethoxy]acetyl]amino]-2,4,6-triiodo-benzoic acid

The solubility of 3-[[2-[2-(3-carboxy-2,4,6-triiodo-anilino)-2-oxo-ethoxy]acetyl]amino]-2,4,6-triiodo-benzoic acid is an intriguing aspect due to its complex structure and the presence of multiple functional groups. The solubility characteristics can be summarized as follows:

  • Aqueous Solubility: This compound may exhibit limited solubility in water owing to its large molecular structure and the presence of hydrophobic iodine atoms, which tend to repel water.
  • Polar Solvents: Given the carboxylic acid and oxo-ethoxy groups, the compound is likely more soluble in polar organic solvents, such as dimethyl sulfoxide (DMSO) or ethanol.
  • pH Sensitivity: The solubility can be influenced by pH levels. For example, in acidic conditions, the carboxylic acid group may remain protonated, enhancing solubility, while in basic conditions, deprotonation may occur, potentially altering the compound's solubility profile.

As a general note, substances that exhibit complex structural features often reveal intriguing solubility behaviors. It is important to state that “the solubility of a compound is dependent not only on the nature of the compound but also on the medium in which it is dissolved.”

In conclusion, the solubility of this compound is expected to be significantly affected by several factors including solvent polarity, pH, and the presence of specific functional groups. Further empirical studies may yield precise solubility data.

Interesting facts

Interesting Facts about 3-[[2-[2-(3-carboxy-2,4,6-triiodo-anilino)-2-oxo-ethoxy]acetyl]amino]-2,4,6-triiodo-benzoic acid

This fascinating compound emerges as a noteworthy illustration of complex organic chemistry, combining multiple functional groups with intriguing properties. Here are some engaging points about it:

  • Structural Complexity: The compound features a highly intricate structure characterized by its multiple iodine substitutions and carboxylic acid groups. This complexity makes it an exciting subject for organic synthesis and medicinal chemistry.
  • Medical Relevance: Compounds with iodine substitutions, like this one, are often used in medical imaging and treatments. Triiodinated compounds are particularly interesting in the field of nuclear medicine, where they can serve as contrast agents for imaging techniques.
  • Biological Activity: Due to its multiple functional groups, this compound exhibits potential biological activities, making it a candidate for drug development. The presence of carboxylic acid increases its solubility in biological fluids, potentially facilitating targeted delivery in therapeutic applications.
  • Environmental Applications: With its unique properties, compounds similar to this one have been studied for use in environmental chemistry, including roles in pollutant degradation or as sensors for detecting harmful substances.
  • Synthesis Challenges: The multi-step synthesis required to produce this compound demands careful planning and execution. Each step needs to be optimized to yield the desired product efficiently while minimizing by-products.

In summary, 3-[[2-[2-(3-carboxy-2,4,6-triiodo-anilino)-2-oxo-ethoxy]acetyl]amino]-2,4,6-triiodo-benzoic acid not only showcases the marvels of synthetic chemistry, but it also hints at numerous possibilities in various fields including pharmaceuticals and environmental science. Its structural intricacy coupled with potential applications makes it a prime subject for study and exploration.

Synonyms
Ioglycamic Acid
ioglycamide
2618-25-9
ioglycamid
Acido ioglicamico
Acide ioglycamique
BE 419
ET36GPP4T7
Benzoic acid, 3,3'-(oxybis((1-oxo-2,1-ethanediyl)imino))bis(2,4,6-triiodo-
BE-419
3-[[2-[2-(3-carboxy-2,4,6-triiodoanilino)-2-oxoethoxy]acetyl]amino]-2,4,6-triiodobenzoic acid
3,3'-(Diglycoloyldiimino)bis(2,4,6-triiodobenzoic acid)
Ioglycaminsaeure
Acidum ioglycamicum
Acidum joglycamicum
UNII-ET36GPP4T7
Acide ioglycamique [INN-French]
Acido ioglicamico [INN-Spanish]
Acidum ioglycamicum [INN-Latin]
Acid, Ioglycamic
Ioglycamic acid [USAN:INN:BAN]
EINECS 220-048-8
SH 419
Benzoic acid,3,3'-[oxybis[(1-oxo-2,1-ethanediyl)imino]]bis[2,4,6-triiodo-
IOGLYCAMIC ACID [MI]
Ioglycamic acid (USAN/INN)
MLS006011720
IOGLYCAMIC ACID [INN]
SCHEMBL433485
IOGLYCAMIC ACID [USAN]
CHEMBL2106372
IOGLYCAMIC ACID [MART.]
N,N'-Oxydiacetyl-bis-(3-amino-2,4,6-triiodbenzoesaeure
DTXSID50180801
IOGLYCAMIC ACID [WHO-DD]
CHEBI:135902
FZDZULUFHNDEDJ-UHFFFAOYSA-N
AKOS022146490
DB13741
SMR002530506
NS00046288
D04577
SR-01000945267
Diglycolic acid bis(2,4,6-triiodo-3-carboxanilide)
Q6062359
SR-01000945267-1
BENZOIC ACID, 3,3'-(OXYBIS((1-OXO-2,1-ETHANEDIYL)IMINO))BIS(2,4,6-TRIIODO)-