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Metoprolol

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Identification
Molecular formula
C15H25NO3
CAS number
37350-58-6
IUPAC name
3-[[2-(2,3-dihydro-1,4-benzodioxin-3-yl)-2-hydroxy-ethyl]amino]propan-1-ol
State
State

At room temperature, Metoprolol is in a solid state. It is typically found as a white to off-white crystalline powder.

Melting point (Celsius)
120.00
Melting point (Kelvin)
393.15
Boiling point (Celsius)
412.00
Boiling point (Kelvin)
685.15
General information
Molecular weight
267.36g/mol
Molar mass
267.3640g/mol
Density
1.1000g/cm3
Appearence

Metoprolol is a white crystalline powder. It may also appear as crystalline solid granules. It is known for being odorless and has a bitter taste.

Comment on solubility

Solubility Characteristics of 3-[[2-(2,3-dihydro-1,4-benzodioxin-3-yl)-2-hydroxy-ethyl]amino]propan-1-ol

The solubility of the compound 3-[[2-(2,3-dihydro-1,4-benzodioxin-3-yl)-2-hydroxy-ethyl]amino]propan-1-ol can be influenced by several factors:

  • Polarity: The presence of hydroxyl groups and nitrogen atoms in the structure enhances the polarity of this compound, leading to increased solubility in polar solvents such as water.
  • Hydrogen Bonding: The ability of the molecule to form hydrogen bonds can improve solubility. In this compound, the hydroxyl (-OH) groups can donate and accept hydrogen bonds, facilitating solubility in aqueous solutions.
  • Aromatic Interactions: The benzodioxin moiety may contribute to solubility in organic solvents due to hydrophobic interactions, potentially allowing for a mixed solubility profile in various solvents.
  • pH Dependence: In a solution with varying pH levels, the ionization state of the amino group could alter the solubility characteristics. An increase in pH could enhance solubility due to the formation of a charged species.

In summary, the solubility behavior of this complex compound is a result of intermolecular forces such as hydrogen bonding and *polarity*. Understanding these aspects is crucial for its applications in various fields including pharmaceuticals and materials science.

Interesting facts

Interesting Facts about 3-[[2-(2,3-dihydro-1,4-benzodioxin-3-yl)-2-hydroxy-ethyl]amino]propan-1-ol

This compound is a fascinating example of how organic chemistry can intertwine with medicinal chemistry, as its structure suggests potential therapeutic applications. Here are some intriguing aspects of this compound:

  • Structural Complexity: The presence of a benzodioxin moiety in its chemical structure indicates unique electronic characteristics and potential interactions with biological systems.
  • Medicinal Properties: Compounds with similar structures often exhibit pharmaceutical properties such as antitumor or anti-inflammatory effects. The hydroxyl groups may contribute to its potential reactivity and interaction with enzymes.
  • Functional Groups: This compound contains multiple functional groups, including amine and alcohol groups, which may enhance solubility and reactivity, paving the way for various synthetic derivations.
  • Research Interest: The complexity and potential biological activity of this compound make it an interesting subject for research in drug development aimed at treating various diseases.
  • Analog Synthesis: Chemists often explore analogs of such compounds, which can help in understanding structure-activity relationships and optimizing their efficacy.

As we decipher the potential uses of this compound, it is essential to explore its reactivity patterns, interactions in biological systems, and possibilities for synthesizing analogs that could lead to breakthroughs in medicinal chemistry.

In conclusion, the study of 3-[[2-(2,3-dihydro-1,4-benzodioxin-3-yl)-2-hydroxy-ethyl]amino]propan-1-ol is not just an academic exercise but a journey into the realms of complex organic synthesis and potential therapeutic applications.

Synonyms
13627-76-4
BRN 1385903
2689 I.S.
alpha-(((3-Hydroxypropyl)amino)methyl)-1,4-benzodioxan-2-methanol
1,4-BENZODIOXAN-2-METHANOL, alpha-(((3-HYDROXYPROPYL)AMINO)METHYL)-
2-(1-Idrossi-2-(gamma-idrossipropilammino))etil-1,4-benzodiossano [Italian]
2-(1-Idrossi-2-(gamma-idrossipropilammino))etil-1,4-benzodiossano
3-[[2-(2,3-dihydro-1,4-benzodioxin-3-yl)-2-hydroxyethyl]amino]propan-1-ol
alpha-[[(3-Hydroxypropyl)amino]methyl]-1,4-benzodioxane-2-methanol
DTXSID60929309
3-{[2-(2,3-Dihydro-1,4-benzodioxin-2-yl)-2-hydroxyethyl]amino}propan-1-ol