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Ipratropium bromide

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Identification
Molecular formula
C20H34BrNO3
CAS number
60205-81-4
IUPAC name
3-[2-[3-[2-(9,9-dimethyl-3-aza-9-azoniabicyclo[3.3.1]nonan-3-yl)ethoxy]phenoxy]ethyl]-9,9-dimethyl-3-aza-9-azoniabicyclo[3.3.1]nonane
State
State

At room temperature, ipratropium bromide is typically found in a solid state. It is often formulated as a solution or spray for use as a bronchodilator in medical applications.

Melting point (Celsius)
234.50
Melting point (Kelvin)
507.65
Boiling point (Celsius)
275.00
Boiling point (Kelvin)
548.15
General information
Molecular weight
430.38g/mol
Molar mass
430.3760g/mol
Density
1.1999g/cm3
Appearence

Ipratropium bromide is a white to off-white crystalline powder. It is highly hygroscopic and is freely soluble in water and methanol, but practically insoluble in non-polar solvents such as chloroform or ether.

Comment on solubility

Solubility of 3-[2-[3-[2-(9,9-dimethyl-3-aza-9-azoniabicyclo[3.3.1]nonan-3-yl)ethoxy]phenoxy]ethyl]-9,9-dimethyl-3-aza-9-azoniabicyclo[3.3.1]nonane

This compound exhibits unique solubility characteristics influenced by its complex structure. Here are some key points regarding its solubility:

  • Aqueous Solubility: Due to the presence of quaternary ammonium groups, which are known to enhance solubility, this compound may have significant solubility in polar solvents like water.
  • Organic Solvents: Its solubility in organic solvents, such as ethanol or acetone, might be favorable due to the hydrophobic characteristics of the alkyl chains.
  • Temperature Dependence: Solubility may vary with temperature; generally, increased temperature can enhance solubility for many compounds.
  • pH Sensitivity: The solubility can also be influenced by the pH of the solution, especially due to the presence of basic nitrogen atoms in the structure.

As a result, the solubility profile of this compound can be described as potentially high in certain conditions, influenced by both its ionic and hydrophobic segments. Understanding the solubility behavior is crucial for applications in biological systems, where solubility directly affects bioavailability and efficacy. Moreover, it is essential to note that variations in solubility can lead to changes in the compound's behavior in different environments, making it an interesting subject for further investigation.

Interesting facts

Interesting Facts about 3-[2-[3-[2-(9,9-Dimethyl-3-aza-9-azoniabicyclo[3.3.1]nonan-3-yl)ethoxy]phenoxy]ethyl]-9,9-dimethyl-3-aza-9-azoniabicyclo[3.3.1]nonane

This fascinating compound belongs to a unique class of chemical compounds known as quaternary ammonium salts. They are notable for possessing a positively charged nitrogen atom, which lends them important characteristics in various applications.

Key Characteristics:

  • Structural Complexity: The intricate structure of this compound involves bicyclic systems and multiple functional groups, illustrating the creativity and complexity in organic synthesis.
  • Biological Relevance: Compounds with similar structures are often studied for their biological activity, potentially acting as pharmaceutical agents or herbicides.
  • Solubility Modification: The presence of ethoxy and phenoxy groups enhances the solubility of the compound, making it more versatile for various chemical reactions and applications.
  • Charge Properties: The quaternary nitrogen atom imparts unique interactions with biological membranes, which could lead to interesting applications in drug delivery systems.

In the realm of medicinal chemistry, compounds with such structures are explored for their ability to modulate biological pathways. As researchers push the frontiers of science, they continually examine how altering different segments of complex compounds can influence their efficacy and selectivity.

In the words of chemists: "Understanding the structure-activity relationship in quaternary ammonium compounds is key to designing more effective therapeutic agents."

This compound, with its remarkable architecture, embodies the intersection of complexity and utility in modern chemistry, representing ongoing research and possibilities.