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Norharmane

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Identification
Molecular formula
C13H12N2
CAS number
244-61-1
IUPAC name
3-[2-(4-pyridyl)ethyl]-1H-indole
State
State

Norharmane is typically a solid at room temperature. It is relatively stable under normal conditions, but it should be handled with care to prevent decomposition due to light or air exposure.

Melting point (Celsius)
102.00
Melting point (Kelvin)
375.15
Boiling point (Celsius)
375.00
Boiling point (Kelvin)
648.15
General information
Molecular weight
182.23g/mol
Molar mass
182.2340g/mol
Density
1.2300g/cm3
Appearence

Norharmane is a white to light yellow crystalline solid. It is free-flowing and its appearance may become slightly off-color upon exposure to air or light over time. It is typically obtained in its crystalline form.

Comment on solubility

Solubility of 3-[2-(4-pyridyl)ethyl]-1H-indole

The solubility of 3-[2-(4-pyridyl)ethyl]-1H-indole is influenced by its unique chemical structure, which contains both indole and pyridine moieties. This compound exhibits nuanced solubility properties that can be categorized as follows:

  • Solvent Dependency: It shows varying solubility in different solvents. It is known to be more soluble in organic solvents such as ethanol, dimethyl sulfoxide (DMSO), and methanol than in water.
  • Hydrophobic Characteristics: The indole structure contributes to a degree of hydrophobicity, which can limit aqueous solubility, particularly in polar solvents.
  • pH Sensitivity: The solubility may shift depending on the pH of the environment, with the pyridine nitrogen potentially becoming protonated in acidic conditions, affecting solubility behavior.

Overall, while 3-[2-(4-pyridyl)ethyl]-1H-indole is not highly soluble in water, its enhanced solubility in organic solvents can be leveraged in various applications. As a rule of thumb, compounds that possess both hydrophilic and hydrophobic regions tend to have a solubility profile that necessitates careful consideration of the solvent medium.

Interesting facts

Interesting Facts about 3-[2-(4-pyridyl)ethyl]-1H-indole

3-[2-(4-pyridyl)ethyl]-1H-indole is a fascinating compound that plays a significant role in various scientific fields, especially in medicinal chemistry and research applications. Here are some compelling aspects to consider:

  • Structural Diversity: The compound features an indole core, which is a bicyclic structure that comprises a fused benzene and pyrrole ring. This structural diversity contributes to its numerous biological activities.
  • Biological Significance: Indole derivatives, including this compound, are known for their potential therapeutic properties, including anti-cancer and anti-inflammatory effects. They often interact with biological targets in significant ways.
  • Pyridine Integration: The presence of the 4-pyridyl group enhances its chemical properties, making it a valuable target for various chemical transformations or interactions.
  • Research Applications: Due to its unique structure, it is of interest in the study of receptor binding and cellular signaling pathways, which have implications in pharmacology and drug design.
  • Versatile Chemical Reactions: This compound can be subjected to a variety of chemical reactions, including nucleophilic substitutions and coupling reactions, which are fundamental in the synthesis of more complex molecules.

As a chemical scientist, exploring 3-[2-(4-pyridyl)ethyl]-1H-indole opens up pathways to not only develop new pharmaceuticals but also to enhance our understanding of biochemical processes. The compound’s versatility and potential for innovation make it an exciting subject of study in contemporary chemistry.

Synonyms
INHIBITOR OF P38 KINASE
3-(2-(4-pyridyl)ethyl)indole
2X6GDX4TXP
3-[2-(4-Pyridyl)ethyl]indole
621-143-0
16571-49-6
3-(2-(Pyridin-4-yl)ethyl)-1H-indole
3-(2-PYRIDIN-4-YLETHYL)-1H-INDOLE
3-[2-(pyridin-4-yl)ethyl]-1H-indole
1H-Indole, 3-[2-(4-pyridinyl)ethyl]-
MFCD00022775
3-[2-(4-Pyridyl)ethyl]-1H-indole
3-(2-Pyridin-4-yl-ethyl)-1H-indole
Maybridge1_000718
Cambridge id 5373101
Oprea1_420786
Oprea1_574113
L12
SCHEMBL735580
CHEMBL193156
SCHEMBL28807264
SCHEMBL31060530
BDBM13346
HMS543I14
1w84
UUEYCHLWAOBOHG-UHFFFAOYSA-N
DTXSID701010192
HMS3604M06
3-[2-(4-pyridyl)-ethyl]-indole
CCG-45397
STL328644
Indole, 3-[2-(4-pyridyl)ethyl]-
AKOS000545583
DB01953
3-[2-(4-pyridinyl)ethyl]-1H-indole
AS-62563
DA-25441
ST095170
SY270769
CS-0324227
NS00068213
D93984
AB00083276-01
SR-01000635166-1
Q27093052