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3-(2-Aminoethyl)benzo[b]thiophen-5-ol

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Identification
Molecular formula
C10H11NOS
CAS number
.Not Available.
IUPAC name
3-(2-aminoethyl)benzothiophen-5-ol
State
State

At room temperature, 3-(2-aminoethyl)benzothiophen-5-ol is typically found in a solid state. It presents in a crystalline form and tends to absorb moisture when exposed to air.

Melting point (Celsius)
142.00
Melting point (Kelvin)
415.15
Boiling point (Celsius)
378.30
Boiling point (Kelvin)
651.45
General information
Molecular weight
193.27g/mol
Molar mass
193.2650g/mol
Density
1.3362g/cm3
Appearence

3-(2-aminoethyl)benzothiophen-5-ol appears as a white to off-white solid. It is typically crystalline in texture and is sensitive to air and humidity. The compound may have a slight odor typical of thiophenes.

Comment on solubility

Solubility of 3-(2-aminoethyl)benzothiophen-5-ol (C10H11NOS)

The solubility characteristics of 3-(2-aminoethyl)benzothiophen-5-ol are influenced by its unique chemical structure. This compound contains a benzothiophene core, an aminoethyl group, and a hydroxyl group, which collectively contribute to its solubility behavior.

Key Factors Influencing Solubility:

  • Polarity: The presence of the hydroxyl (–OH) group tends to increase polarity, enhancing solubility in polar solvents such as water.
  • Amino Group: The amino group can engage in hydrogen bonding, further increasing solubility in polar environments.
  • Structural Considerations: The compact nature of the molecule may also facilitate interaction with other molecules, especially in organic solvent systems.

As a result, the solubility of 3-(2-aminoethyl)benzothiophen-5-ol is expected to be moderate in water and may vary significantly in organic solvents, largely dependent on their polarity. In terms of practical applications, understanding the solubility profile is essential for optimizing conditions in formulations, particularly in pharmaceutical contexts.

Considerations:

  • Conduct solubility testing across a range of solvents.
  • Monitor temperature as it can significantly affect solubility results.
  • Apply techniques such as pH adjustment for enhancing solubility in aqueous solutions.

In conclusion, the solubility of 3-(2-aminoethyl)benzothiophen-5-ol presents intriguing avenues for research and application, highlighting the balance of structural features that govern its behavior in various environments.

Interesting facts

Exploring 3-(2-aminoethyl)benzothiophen-5-ol

3-(2-aminoethyl)benzothiophen-5-ol is a fascinating compound that has intrigued chemists due to its unique structure and potential applications. Here are some interesting facts about this compound:

  • Structural Diversity: This compound features a benzothiophene core, which is a fused bicyclic structure that incorporates sulfur. The presence of an aminoethyl side chain enhances its chemical properties and reactivity.
  • Pharmacological Potential: Compounds of this nature often exhibit biologically active properties. Research suggests that benzothiophenes can have roles in medicinal chemistry, potentially serving as leads for developing new drugs, particularly in the area of neuropharmacology.
  • Intermolecular Interactions: The presence of multiple functional groups allows for intriguing intermolecular interactions. The ability for this compound to participate in hydrogen bonding is crucial for its solubility and biological activity.
  • Fluorescence: The aromatic nature of the benzothiophene framework may suggest photophysical properties, which can be advantageous in various sensing applications. Fluorescent properties can be manipulated based on environmental changes.
  • Chemical Synthesis: The synthesis of such compounds often involves multi-step processes, allowing for the introduction of diverse functional groups. This offers a fantastic opportunity for students and researchers alike to explore synthetic methodologies and reaction mechanisms.

As a student or researcher, understanding the nuances of 3-(2-aminoethyl)benzothiophen-5-ol can lead you to appreciate the intricate balance between structure and function in organic compounds. The exploration of such compounds not only broadens the horizons of organic chemistry but also lays the foundation for advances in pharmaceutical sciences.

Synonyms
13012-93-6
BRN 1309943
3-(2-Aminoethyl)benzo(b)thiophen-5-ol
BENZO(b)THIOPHEN-5-OL, 3-(2-AMINOETHYL)-
DTXSID80156357
DTXCID3078848
3-(2-aminoethyl)-1-benzothiophen-5-ol
3-(2-aminoethyl)-1-benzothiophene-5-ol
SCHEMBL8586692
CHEBI:125664
NAA01293
EN300-7465285
BRD-K88575585-001-01-2
Q27216274