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Benzhexol hydrochloride

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Identification
Molecular formula
C21H26ClNO
CAS number
552-24-3
IUPAC name
3-(2-azoniabicyclo[2.2.2]octan-2-yl)-1,1-diphenyl-butan-1-ol;chloride
State
State

At room temperature, benzhexol hydrochloride is in a solid state. Its crystalline form is often used for various pharmaceutical applications.

Melting point (Celsius)
261.00
Melting point (Kelvin)
534.15
Boiling point (Celsius)
0.00
Boiling point (Kelvin)
0.00
General information
Molecular weight
339.90g/mol
Molar mass
339.8980g/mol
Density
1.0800g/cm3
Appearence

Benzhexol hydrochloride appears as a crystalline powder, which is typically white in color. It is known to absorb moisture from the air, making it hygroscopic, and is often used in its salt form for medicinal purposes.

Comment on solubility

Solubility Characteristics of 3-(2-azoniabicyclo[2.2.2]octan-2-yl)-1,1-diphenyl-butan-1-ol;chloride

The compound 3-(2-azoniabicyclo[2.2.2]octan-2-yl)-1,1-diphenyl-butan-1-ol;chloride exhibits intriguing solubility properties that are influenced by its unique chemical structure. This compound is a salt due to the presence of the chloride ion, which plays a significant role in its solubility profile.

Solubility in Different Solvents

Understanding its solubility is essential for practical applications. Generally, the solubility of this compound can be categorized as follows:

  • Water: As an ionic compound, it is likely to be soluble in water, although the degree of solubility may vary based on the temperature and pH.
  • Organic Solvents: The presence of aromatic (diphenyl) groups suggests that it may exhibit solubility in non-polar to slightly polar organic solvents such as ethanol or acetone.
  • Solubility in Acidic Medium: The chloride ion may enhance solubility in acidic conditions, where the compound could be more ionized.

Some key points about its solubility include:

  • The hydrophilic azabicyclic structure may aid interaction with polar solvents.
  • Diphenyl substitutions typically contribute to non-polar interactions, which can influence solubility in organic phases.
  • Temperature can significantly affect the solubility dynamics of this compound.

In summary, the solubility of 3-(2-azoniabicyclo[2.2.2]octan-2-yl)-1,1-diphenyl-butan-1-ol;chloride can be described as somewhat versatile, with notable solubility in water and organic solvents while being influenced by external factors such as pH and temperature. Further studies could provide additional insights into optimizing its solubility for various applications.

Interesting facts

Interesting Facts about 3-(2-azoniabicyclo[2.2.2]octan-2-yl)-1,1-diphenyl-butan-1-ol; chloride

This intriguing compound, commonly referred to in the scientific community for its structural complexity, presents multiple avenues for exploration. At the heart of its unique characteristics is the bicyclic azonium structure, which plays a pivotal role in its chemical reactivity and stability.

Key Features:

  • Bicyclic Azoionium Structure: The bicyclo[2.2.2]octane element contributes to the compound's three-dimensional shape, enabling distinctive interactions with biological targets.
  • Diphenyl Group: The presence of two phenyl rings adds considerable steric hindrance, influencing the compound's solubility and reactivity.
  • Ion Exchange Potential: The chloride component suggests potential applications in ionic exchanges, making this compound valuable in various chemical processes.

In pharmaceutical chemistry, such compounds could serve as intermediates or building blocks for more complex molecules, particularly in drug development targeting specific receptors. The combination of the azabicyclo framework and functionalized alcohol groups may lead to novel therapeutic agents with heightened selectivity and efficacy.

As one researcher aptly put it, *"The chemistry of bicyclic compounds continues to unveil new methodologies for synthesis and application in medicinal chemistry."* This compound exemplifies such potential, echoing the ongoing innovations fueled by structural diversity in organic synthesis.

Moreover, exploring the interactions of 3-(2-azoniabicyclo[2.2.2]octan-2-yl)-1,1-diphenyl-butan-1-ol with various biological systems could yield insight into its pharmacodynamics and efficacy as a drug candidate.

Synonyms
2-Azabicyclo(2.2.2)octane-2-propanol, beta-methyl-alpha,alpha-diphenyl-, hydrochloride
21206-72-4
1,1-Diphenyl-2-methyl-3-(2-azabicyclo(2.2.2)oct-2-yl)propanol hydrochloride
alpha-(2-(2-Azabicyclo(2.2.2)oct-2-yl)-1-methylethyl)benzhydrol hydrochloride
Benzhydrol, alpha-(2-(2-azabicyclo(2.2.2)oct-2-yl)-1-methylethyl)-, hydrochloride
RefChem:256127