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Lofepramine

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Identification
Molecular formula
C26H27ClN2
CAS number
23047-25-8
IUPAC name
3-(2-chloro-5,6-dihydrobenzo[b][1]benzazepin-11-yl)-N,N-dimethyl-propan-1-amine
State
State

At room temperature, lofepramine typically exists as a solid.

Melting point (Celsius)
93.50
Melting point (Kelvin)
366.65
Boiling point (Celsius)
616.20
Boiling point (Kelvin)
889.35
General information
Molecular weight
435.96g/mol
Molar mass
435.9490g/mol
Density
1.2370g/cm3
Appearence

Lofepramine is typically found in its pure form as a white to off-white crystalline powder.

Comment on solubility

Solubility of 3-(2-chloro-5,6-dihydrobenzo[b][1]benzazepin-11-yl)-N,N-dimethyl-propan-1-amine (C26H27ClN2)

The solubility characteristics of 3-(2-chloro-5,6-dihydrobenzo[b][1]benzazepin-11-yl)-N,N-dimethyl-propan-1-amine can be quite fascinating, as it encompasses a variety of factors that dictate its behavior in different solvents. Here are some key points to consider:

  • Polar vs. Nonpolar Solvents: This compound, containing both aromatic and aliphatic structures, may exhibit different solubility in polar solvents (like water) compared to nonpolar solvents (such as hexane). Generally, compounds with significant hydrophobic character tend to be more soluble in nonpolar environments.
  • Ionization: The presence of the amine group (N,N-dimethyl) suggests potential for protonation, which can affect solubility, especially in acidic conditions where the compound might exist as a charged species.
  • Temperature Influence: Solubility is temperature-dependent. Increased temperatures can enhance the solubility of many organic compounds, so it’s pivotal to consider the conditions under which the solubility is measured.
  • Crystallinity: The crystalline structure of the compound may impact solubility; non-crystalline forms (like amorphous powders) usually dissolve more readily than their crystalline counterparts.

In summary, while the specific solubility data for C26H27ClN2 may not be immediately available, assessing its solubility requires an understanding of its molecular interactions within various solvents. As the saying goes, "like dissolves like," and thus, the interaction of this compound with diverse solvent systems will ultimately determine its solubility profile. Experimentation under controlled conditions will provide precise insights!

Interesting facts

Interesting Facts about 3-(2-chloro-5,6-dihydrobenzo[b][1]benzazepin-11-yl)-N,N-dimethyl-propan-1-amine

This compound, known for its complex chemical structure, belongs to a fascinating class of organic substances that can have diverse applications in the field of medicinal chemistry. Here are some interesting facts:

  • Pharmacological Potential: This compound is associated with potential therapeutic effects. Its unique structure allows it to interact with various biological targets, making it a subject of interest in the search for novel drugs.
  • Complex Structure: The presence of the 2-chloro-5,6-dihydrobenzo[b][1]benzazepin moiety introduces significant steric and electronic properties that may affect its biochemical interactions.
  • Dimethylamine Substitution: The N,N-dimethyl group is known to enhance the lipophilicity of molecules, which can increase their ability to cross biological membranes and reach intracellular targets.
  • Analogous Compounds: This compound can be compared to other psychoactive substances due to its structural similarities, opening discussions about its potential effects on the central nervous system.
  • Research Interest: As a member of the benzazepine family, it captivates chemists and pharmacologists alike. Its study can provide insights into mechanisms of action and efficacy of compounds with similar architectures.
  • What's in a Name? The intricate naming of this compound reflects the careful consideration of its molecular components, delivering a wealth of information packed into a single title.

In summary, the compound 3-(2-chloro-5,6-dihydrobenzo[b][1]benzazepin-11-yl)-N,N-dimethyl-propan-1-amine captivates researchers due to its complex structure and potential pharmacological applications. Further investigation may unlock its secrets and harness its therapeutic potential.

Synonyms
clomipramine
Chlorimipramine
303-49-1
Monochlorimipramine
3-Chloroimipramine
Hydiphen
Anafranil base
Clomicalm
Anafranil (free base)
3-(3-chloro-10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)-N,N-dimethylpropan-1-amine
Clomipramina
Clomipraminum
Clomipraminum [INN-Latin]
Clomipramina [INN-Spanish]
Anapramine
NSC 169865
5H-Dibenz[b,f]azepine-5-propanamine, 3-chloro-10,11-dihydro-N,N-dimethyl-
3-Chloro-Iminodibenzyl
3-Chloro-5-(3-(dimethylamino)propyl)-10,11-dihydro-5H-dibenz(b,f)azepine
EINECS 206-144-2
UNII-NUV44L116D
5H-Dibenz(b,f)azepine, 10,11-dihydro-3-chloro-5-(3-(dimethylamino)propyl)-
NSC-169865
BRN 1323477
Clomipramine (INN)
NUV44L116D
DTXSID6022844
CHEBI:47780
HSDB 7746
5H-Dibenz(b,f)azepine-5-propanamine, 3-chloro-10,11-dihydro-N,N-dimethyl-
3-(2-chloro-5,6-dihydrobenzo[b][1]benzazepin-11-yl)-N,N-dimethylpropan-1-amine
Anafranil (TN)
5H-Dibenz(b,f)azepine, 3-chloro-5-(3-(dimethylamino)propyl)-10,11-dihydro-
DTXCID602844
Chlomipramine
G 34586
5-20-08-00103 (Beilstein Handbook Reference)
3-(3-Chloro-10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)-N,N-dimethyl-1-propanamine
NCGC00015264-08
CLOMIPRAMINE [INN]
Clomipraminum (INN-Latin)
Clomipramina (INN-Spanish)
N,N-Dimethyl-7-chloro-10,11-dihydro-5H-dibenzo[b,f]azepine-5-propanamine-2,4-D2
Clomipramine [INN:BAN]
2241983-11-7
Anapramine; Chlorimipramine;G 34586; NSC 169865
3-chloro-10,11-dihydro-N,N-dimethyl-5H-Dibenz(b,f)azepine-5-propanamine
3-CHLORO-10,11-DIHYDRO-N,N-DIMETHYL-5H-DIBENZ[B,F]AZEPINE-5-PROPANAMINE
CAS-303-49-1
CLOMIPRAMINE (EMA EPAR VETERINARY)
CLOMIPRAMINE [EMA EPAR VETERINARY]
NSC169865
CAS-17321-77-6
Maronil
3-chloro-5-(3-(dimethylamino)propyl)-10,11-dihydro-5H-dibenz[b,f]azepine
3-(3-chloro-10,11-dihydro-5H-dibenzo(b,f)azepin-5-yl)-N,N-dimethyl-1-propanamine
3-(3-chloro-10,11-dihydro-5H-dibenzo(b,f)azepin-5-yl)-N,N-dimethylpropan-1-amine
5H-Dibenz[b,f]azepine, 3-chloro-5-[3-(dimethylamino)propyl]-10,11-dihydro-
MFCD00242755
CLOMIPRIMINE
Spectrum_000444
Tocris-0457
Clomipramine (Standard)
3-(2-chloro-5,6-dihydrobenzo[b][1]benzazepin-11-yl)-N,N-dimethylpropan-1-amine;hydrochloride
Prestwick0_000269
Prestwick1_000269
Prestwick2_000269
Prestwick3_000269
Spectrum2_001729
Spectrum3_001707
Spectrum4_000350
Spectrum5_001235
CLOMIPRAMINE [MI]
Lopac-C-7291
Biomol-NT_000151
CHEMBL415
CLOMIPRAMINE [HSDB]
CLOMIPRAMINE [VANDF]
BIDD:PXR0151
Lopac0_000307
Oprea1_312582
SCHEMBL35423
BSPBio_000118
BSPBio_003294
KBioGR_000759
KBioSS_000924
cid_68539
CLOMIPRAMINE [WHO-DD]
DivK1c_000797
SPBio_001778
SPBio_002337
BPBio1_000130
BPBio1_000661
GTPL2398
HY-B0457AR
BDBM77970
HY-B0457A
KBio1_000797
KBio2_000924
KBio2_003492
KBio2_006060
KBio3_002514
N06AA04
NINDS_000797
HMS3428J14
Tox21_110117
MFCD31699980
PDSP1_000241
PDSP2_000240
STK534842
10,11-dihydro-3-chloro-5-(3-(dimethylamino)propyl)-5H-dibenz(b,f)azepine
AKOS001487687
Tox21_110117_1
AB05476
CCG-110307
DB01242
DS-6718
SDCCGSBI-0050295.P004
3-(2-chloro-5,6-dihydrobenzo[b][1]benzazepin-11-yl)-N,N-dimethyl-propan-1-amine
IDI1_000797
NCGC00015264-01
NCGC00015264-02
NCGC00015264-03
NCGC00015264-04
NCGC00015264-05
NCGC00015264-06
NCGC00015264-07
NCGC00015264-09
NCGC00015264-10
NCGC00015264-13
NCGC00015264-25
NCGC00024355-02
NCGC00024355-04
NCGC00024355-05
DA-51968
SY246341
SBI-0050295.P003
AB00053695
CS-0012495
NS00000038
C06918
C74557
D07727
Q58713
AB00053695-14
AB00053695_15
AB00053695_16
EN300-6733614
L000890
3-Chloro-5-[3-(dimethylamino)propyl]-10,f]azepine
5H-Dibenz[b, 3-chloro-10,11-dihydro-N,N-dimethyl-
BRD-K52989797-001-01-1
BRD-K52989797-003-05-8
BRD-K52989797-003-16-5
BRD-K52989797-003-26-4
BRD-K52989797-003-27-2
BRD-K52989797-003-28-0
WLN: T C676 BN & T & J B3N1 & 1 EG
5H-Dibenz[b, 10,11-dihydro-3-chloro-5-[3-(dimethylamino)propyl]-
5H-Dibenz[b, 3-chloro-5-[3-(dimethylamino)propyl]-10,11-dihydro-
3-chloro-5-(3-dimethylamino)-propyl)-10,11-dihydro-5H-dibenz(b,f)azepine
3-(2-chloro-5,6-dihydrobenzo[b][1]benzazepin-11-yl)propyl-dimethyl-amine;hydrochloride
3-(3-Chloro-10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)-N,N-dimethyl-1-propanamine #
3-(9-chloro-5,6-dihydrobenzo[b][1]benzazepin-11-yl)-N,N-dimethylpropan-1-amine
5H-Dibenz(b,f)azepine, 3-chloro-5-(3-(dimethylamino)propyl)-10,11-dihydro- (8CI)
N-[3-(3-chloro-10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)propyl]-N,N-dimethylamine
(3-{5-chloro-2-azatricyclo[9.4.0.0,3,8]pentadeca-1(11),3(8),4,6,12,14-hexaen-2-yl}propyl)dimethylamine
(3-{5-chloro-2-azatricyclo[9.4.0.0^{3,8}]pentadeca-1(11),3(8),4,6,12,14-hexaen-2-yl}propyl)dimethylamine
206-144-2
3-(2-chloranyl-5,6-dihydrobenzo[b][1]benzazepin-11-yl)-N,N-dimethyl-propan-1-amine;hydrochloride
3-(2-chloro-5,6-dihydrobenzo[b][1]benzazepin-11-yl)-N,N-dimethyl-1-propanamine;hydrochloride
CIM