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Clomipramine

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Identification
Molecular formula
C19H23ClN2
CAS number
303-49-1
IUPAC name
3-(2-chloro-5,6-dihydrobenzo[b][1]benzazepin-11-yl)-N,N,2-trimethyl-propan-1-amine
State
State

Solid

Melting point (Celsius)
186.00
Melting point (Kelvin)
459.00
Boiling point (Celsius)
560.00
Boiling point (Kelvin)
833.00
General information
Molecular weight
314.87g/mol
Molar mass
314.8670g/mol
Density
1.1550g/cm3
Appearence

Clomipramine is a white to off-white crystalline powder. It is usually supplied for pharmaceutical use as tablets or capsules.

Comment on solubility

Solubility of 3-(2-chloro-5,6-dihydrobenzo[b][1]benzazepin-11-yl)-N,N,2-trimethyl-propan-1-amine

The solubility of the compound 3-(2-chloro-5,6-dihydrobenzo[b][1]benzazepin-11-yl)-N,N,2-trimethyl-propan-1-amine presents intriguing aspects that are worth noting. Generally, the solubility of such amines can be influenced by various factors, including the following:

  • Polarity: The presence of polar functional groups can enhance solubility in polar solvents, while non-polar sections may favor solubility in organic solvents.
  • Hydrogen Bonding: Amine groups can engage in hydrogen bonding, which may improve solubility in water.
  • Molecular Weight: Higher molecular weight usually correlates with lower solubility, and this compound has a relatively complex structure.

Due to its specific chemical structure, this compound may exhibit:

  • Moderate solubility in organic solvents, like ethanol or methanol.
  • Limited solubility in water, given the bulky nature of the organic substituents.

As a general rule, when dealing with similar compounds, it can be observed that “like dissolves like,” meaning polar compounds tend to dissolve in polar solvents while non-polar substances are better solubilized in non-polar environments. Overall, detailed solubility testing under varying conditions is essential to accurately determine the solubility profile for this compound.

Interesting facts

Interesting Facts about 3-(2-chloro-5,6-dihydrobenzo[b][1]benzazepin-11-yl)-N,N,2-trimethyl-propan-1-amine

This complex compound is noteworthy due to its unique structure and potential applications in pharmacology. Here are some compelling aspects:

  • Pharmacological Potential: Compounds like this one are often explored for their potential as therapeutic agents. Research may focus on their efficacy against various medical conditions, particularly in the fields of psychiatry and neurology, due to its resemblance to known psychoactive substances.
  • Structural Complexity: The presence of multiple rings and functional groups in its structure adds to its intrigue. This complexity often suggests unique properties—both physical and chemical—that could be exploited in drug design.
  • Chloro-Substitution: The presence of the chlorine atom can significantly alter the reactivity and biological activity of the molecule, making it a key focus during synthesis and optimization of similar compounds.
  • Trimethylamine Moiety: The trimethylamine component contributes to the molecule's basicity, which may affect its interactions with biological targets, potentially influencing drug absorption and distribution.
  • Research Frontier: The structure is a part of a broader family of compounds that are being investigated for their role in neurotransmission and receptor activity, thus opening up avenues for innovative therapies.

In summary, the investigation of 3-(2-chloro-5,6-dihydrobenzo[b][1]benzazepin-11-yl)-N,N,2-trimethyl-propan-1-amine is a great example of the cutting-edge research occurring in medicinal chemistry. As students and scientists delve into its aspects, they contribute to a greater understanding of both the molecule itself and its potential therapeutic applications.

Synonyms
3-Chloro-beta-methylimipramine
29W4IW64HG
UNII-29W4IW64HG
1043-24-9
3-Chloro-10,11-dihydro-N,N,beta-trimethyl-5H-dibenz(b,f)azepine-5-propanamine
5H-Dibenz(b,f)azepine-5-propanamine, 3-chloro-10,11-dihydro-N,N,beta-trimethyl-
3-CHLORO-.BETA.-METHYLIMIPRAMINE
3-CHLORO-10,11-DIHYDRO-N,N,.BETA.-TRIMETHYL-5H-DIBENZ(B,F)AZEPINE-5-PROPANAMINE
5H-DIBENZ(B,F)AZEPINE-5-PROPANAMINE, 3-CHLORO-10,11-DIHYDRO-N,N,.BETA.-TRIMETHYL-